scholarly journals Relationship between common interleukin 1-beta gene polymorphisms and the risk of gestational disorders: An updated meta-analysis

2021 ◽  
Author(s):  
Mahdiyeh Harati-Sadegh ◽  
Saman Sargazi ◽  
Hamed Taheri ◽  
Narges Arbabi ◽  
Ramin Saravani ◽  
...  
Keyword(s):  
Gene Polymorphisms ◽  
Meta Analysis ◽  
Interleukin 1 ◽  
Interleukin 1 Beta ◽  
Beta Gene

scholarly journals Association between interleukin-1 beta gene, interleukin-1 receptor antagonist gene polymorphisms and urolithiasis: A literature review and meta-analysis

2020 ◽  
Vol 18 ◽  
pp. 205873922096239
Author(s):  
Jiaxuan Qin ◽  
Jinchun Xing ◽  
Zonglong Cai
Keyword(s):  
Literature Review ◽  
Receptor Antagonist ◽  
Gene Polymorphisms ◽  
Meta Analysis ◽  
Interleukin 1 ◽  
Interleukin 1 Beta ◽  
Case Control Studies ◽  
Interleukin 1 Receptor Antagonist ◽  
Different Populations ◽  
Beta Gene

Several case-control studies have been performed in different populations to uncover the association between interleukin-1 beta gene, interleukin-1 receptor antagonist gene polymorphisms and urolithiasis. Here we decided to perform a literature review and meta-analysis to further estimate it. A systematic search was conducted in PubMed, Embase, Cochrane, clinicaltrials.gov, CNKI databases. To pool the effect size, odds ratios and 95% confidence intervals were used. Finally, five articles were included. Our results of literature review suggested that IL1RN IVS2 VNTR might be associated with the risk of urolithiasis. However, the results of meta-analysis suggested that IL-1beta -511C>T, IL-1beta +3954C>T, and IL1RN IVS2 VNTR might not be associated with the risk of urolithiasis. There were not enough data to fully confirm this association and the results should be interpreted with caution.

Interleukin-1 beta gene polymorphisms and preterm birth

2012 ◽  
Vol 165 (1) ◽  
pp. 33-36 ◽  
Author(s):  
Maximilian Schmid ◽  
Peter Haslinger ◽  
Susanne Stary ◽  
Heinz Leipold ◽  
Christian Egarter ◽  
...  
Keyword(s):  
Preterm Birth ◽  
Gene Polymorphisms ◽  
Interleukin 1 ◽  
Interleukin 1 Beta ◽  
Beta Gene

Interleukin 1 beta gene and risk of schizophrenia: detailed case-control and family-based studies and an updated meta-analysis

2013 ◽  
Vol 29 (1) ◽  
pp. 31-37 ◽  
Author(s):  
Masako Shibuya ◽  
Yuichiro Watanabe ◽  
Ayako Nunokawa ◽  
Jun Egawa ◽  
Naoshi Kaneko ◽  
...  
Keyword(s):  
Meta Analysis ◽  
Interleukin 1 ◽  
Case Control ◽  
Interleukin 1 Beta ◽  
Detailed Case ◽  
Family Based ◽  
Beta Gene

scholarly journals Keratinocyte growth factor, tumor necrosis factor-alpha and interleukin-1 beta gene expression in cultured fibroblasts and keratinocytes from burned patients

2013 ◽  
Vol 28 (8) ◽  
pp. 551-558 ◽  
Author(s):  
Alfredo Gragnani ◽  
Bruno Rafael Müller ◽  
Ismael Dale Contrim Guerreiro da Silva ◽  
Samuel Marcos Ribeiro de Noronha ◽  
Lydia Masako Ferreira
Keyword(s):  
Gene Expression ◽  
Tumor Necrosis ◽  
Keratinocyte Growth Factor ◽  
Interleukin 1 ◽  
Interleukin 1 Beta ◽  
Necrosis Factor Alpha ◽  
Cultured Fibroblasts ◽  
Factor Alpha ◽  
Beta Gene ◽  
Necrosis Factor

A polymorphism of the interleukin-1 beta gene at position +3953 influences progression and neuro-pathological hallmarks of Alzheimer’s disease

2004 ◽  
Vol 25 (8) ◽  
pp. 1017-1022 ◽  
Author(s):  
Federico Licastro ◽  
Fabrizio Veglia ◽  
Martina Chiappelli ◽  
Luigi Maria E Grimaldi ◽  
Eliezer Masliah
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Interleukin 1 ◽  
Interleukin 1 Beta ◽  
Beta Gene

scholarly journals The human interleukin-1 alpha gene is located on the long arm of chromosome 2 at band q13

Blood ◽  
1989 ◽  
Vol 73 (1) ◽  
pp. 104-107 ◽  
Author(s):  
M Lafage ◽  
N Maroc ◽  
P Dubreuil ◽  
R de Waal Malefijt ◽  
MJ Pebusque ◽  
...  
Keyword(s):  
Interleukin 1 ◽  
Cdna Probe ◽  
Proximal Part ◽  
Chromosome 2 ◽  
Interleukin 1 Beta ◽  
Hematopoietic Growth Factors ◽  
Alpha Gene ◽  
Immunologic Reactions ◽  
Beta Gene

Abstract Interleukin-1 alpha (IL-1 alpha) and interleukin-1 beta (IL-1 beta) are two biochemically distinct, but distantly related, polypeptidic cytokines that play a key role in inflammation, immunologic reactions, and tissue repair. Recently, it has been shown that IL-1 alpha is identical to hematopoietin 1, which was described as a hematopoietic growth factor acting on early progenitor cells in synergy with other hematopoietic growth factors. In this report we discuss our use of in situ hybridization on human prometaphase cells with a human IL-1 alpha cDNA probe to localize the human IL-1 alpha gene on the proximal part of the long arm of chromosome 2 at band q13, in the same chromosomal region as the IL-1 beta gene.

scholarly journals A novel cis-acting element required for lipopolysaccharide-induced transcription of the murine interleukin-1 beta gene.

1995 ◽  
Vol 15 (1) ◽  
pp. 112-119 ◽  
Author(s):  
S A Godambe ◽  
D D Chaplin ◽  
T Takova ◽  
L M Read ◽  
C J Bellone
Keyword(s):  
Binding Site ◽  
Binding Sites ◽  
Competitive Inhibition ◽  
Interleukin 1 ◽  
Sodium Dodecyl ◽  
Regulatory Elements ◽  
Nuclear Factor ◽  
Interleukin 1 Beta ◽  
Factor Binding ◽  
Beta Gene

Regulatory elements important for transcription of the murine interleukin-1 beta (IL-1 beta) gene lie within a DNase I-hypersensitive region located > 2,000 bp upstream from the transcription start site. We have identified within this region a novel positive regulatory element that is required for activation of an IL-1 beta promoter-chloramphenicol acetyltransferase (CAT) fusion gene in the murine macrophage line RAW264.7. Electrophoretic mobility shift analysis of the 3' portion (-2315 to -2106) of the hypersensitive region revealed at least two nuclear factor binding sites, one of which is located between positions -2285 and -2256. Competitive inhibition studies localized the binding site to a 15-bp sequence between -2285 and -2271. Nuclear factor binding was lost by mutation of the 6-bp sequence from -2280 to -2275. The specific retarded complex formed with RAW264.7 nuclear extract was not detected under similar conditions with nuclear extracts from RLM-11, a murine T-cell line which does not express IL-1 beta RNA. Mutation of the 6-bp sequence (-2280 to -2275) in the chimeric IL-1 beta promoter -4093 +I CAT plasmid virtually eliminated the activation of this reporter gene by lipopolysaccharide (LPS) in transfected RAW264.7 cells. Multimerization of the 15-bp sequence containing the core wild-type 6-bp sequence 5' of minimal homologous or heterologous promoters in CAT reporter plasmids resulted in significant enhancement of CAT expression compared with parallel constructs containing the mutant 6-bp core sequence. This element was LPS independent and position and orientation dependent. The multimerized 15-bp sequence did not enhance expression in RLM-11 cells. Methylation interference revealed contact residues from -2281 to -2271, CCAAAAAGGAA. Because a search of the NIH TFD data bank with the 11-bp binding site sequence found no homology to known nuclear factor binding sites, we have designated this sequence the IL1 beta -upstream nuclear factor 1 (IL1 beta -UNF1) target. UV cross-linking and sodium dodecyl sulfate-polyacrylamide electrophoresis identified an IL1 beta -UNF1-specific binding factor approximately 85 to 90 kDa in size.

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