scholarly journals Promotion of Burn Wound Healing by Local Application of Adipose-Derived Mesenchymal Stem Cells: An Experimental Study

2021 ◽  
Author(s):  
Farzane Rezaei Yazdi ◽  
Aziz Ghahary ◽  
Mohammad Mirdoraghi ◽  
Hamzeh Sarvnaz ◽  
Mohammad Hossein Asgardoon ◽  
...  
Keyword(s):  
Stem Cells ◽  
Experimental Study ◽  
Wound Healing ◽  
Mesenchymal Stem Cells ◽  
Local Application ◽  
Burn Wound ◽  
Burn Wound Healing

Bone Marrow-Derived Mesenchymal Stem Cells Combined With Simvastatin Accelerates Burn Wound Healing by Activation of the Akt/mTOR Pathway

2020 ◽  
Vol 41 (5) ◽  
pp. 1069-1078
Author(s):  
Parisa Ramhormozi ◽  
Javad Mohajer Ansari ◽  
Sara Simorgh ◽  
Maliheh Nobakht
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Wound Healing ◽  
Mesenchymal Stem Cells ◽  
Combination Therapy ◽  
Signaling Pathway ◽  
Mtor Signaling Pathway ◽  
Burn Wound ◽  
Qrt Pcr ◽  
Burn Wound Healing

Abstract Burn wound healing is one of the most important problems in the field of medical science. Promising results have recently been reported by researchers who used bone marrow mesenchymal stem cells (BMSCs) to treat burn wounds. In this study, we investigated the effects of BMSC therapy in combination with simvastatin (SMV) on angiogenesis as well as on the activity of the Akt/mTOR signaling pathway during burn wound healing in rats. After creating second-degree burn wounds, 40 adult male Wistar rats were randomly divided into four treatment groups: the control, SMV, BMSCs, and the combination therapy group (BMSCs+SMV). Animals were killed 14 days after treatment initiation, and the wounds were removed for histological and molecular analyses. All in all, combination therapy produced better outcomes than individual therapy in terms of the wound closure area, epidermal regeneration level, collagen deposition intensity, and reepithelialization rate. In addition, the elevations of expression levels of Akt and mTOR genes, at both mRNA and protein levels, were more pronounced in the BMSCs+SMV group (P < .05, at least, for both qRT-PCR and western blot assessments). qRT-PCR findings also demonstrated that the wounds treated with the combination of BMSCs and SMV had the highest expression levels of CD31 and VEGF genes (P < .01 for all comparisons). These data suggest that the combined administration of BMSCs transplantation and topical SMV has a great potential in burn wound healing. According to the findings, the beneficial effects of the combination therapy are caused, at least in part, through stimulating Akt/mTOR signaling pathway.

Comment on “Allogeneic mesenchymal stem cells, but not culture modified monocytes, improve burn wound healing”

Burns ◽  
2015 ◽  
Vol 41 (8) ◽  
pp. 1894-1895
Author(s):  
Jun Zhang ◽  
Xiaowen Huang ◽  
Fu Han ◽  
Dahai Hu
Keyword(s):  
Stem Cells ◽  
Wound Healing ◽  
Mesenchymal Stem Cells ◽  
Burn Wound ◽  
Burn Wound Healing

Allogeneic mesenchymal stem cells, but not culture modified monocytes, improve burn wound healing

Burns ◽  
2015 ◽  
Vol 41 (3) ◽  
pp. 548-557 ◽  
Author(s):  
Anthony J.P. Clover ◽  
Arun H.S. Kumar ◽  
Matthew Isakson ◽  
Derek Whelan ◽  
Alecia Stocca ◽  
...  
Keyword(s):  
Stem Cells ◽  
Wound Healing ◽  
Mesenchymal Stem Cells ◽  
Burn Wound ◽  
Burn Wound Healing

Curcumin promotes burn wound healing in mice by upregulating caveolin-1 in epidermal stem cells

2018 ◽  
Vol 33 (2) ◽  
pp. 422-430 ◽  
Author(s):  
Ronghua Yang ◽  
Jingru Wang ◽  
Ziheng Zhou ◽  
Shaohai Qi ◽  
Shubin Ruan ◽  
...  
Keyword(s):  
Stem Cells ◽  
Wound Healing ◽  
Epidermal Stem Cells ◽  
Burn Wound ◽  
Caveolin 1 ◽  
Burn Wound Healing

scholarly journals The Use of Stem Cells in Burn Wound Healing: A Review

2015 ◽  
Vol 2015 ◽  
pp. 1-9 ◽  
Author(s):  
Fadi Ghieh ◽  
Rosalyn Jurjus ◽  
Amir Ibrahim ◽  
Alice Gerges Geagea ◽  
Hisham Daouk ◽  
...  
Keyword(s):  
Stem Cells ◽  
Wound Healing ◽  
Therapeutic Effect ◽  
Healing Time ◽  
Burn Injuries ◽  
Burn Wound ◽  
Burn Wounds ◽  
Complex Processes ◽  
Burn Wound Healing

Burn wound healing involves a series of complex processes which are subject to intensive investigations to improve the outcomes, in particular, the healing time and the quality of the scar. Burn injuries, especially severe ones, are proving to have devastating effects on the affected patients. Stem cells have been recently applied in the field to promote superior healing of the wounds. Not only have stem cells been shown to promote better and faster healing of the burn wounds, but also they have decreased the inflammation levels with less scar progression and fibrosis. This review aims to highlight the beneficial therapeutic effect of stem cells in burn wound healing and to discuss the involved pathways and signaling molecules. The review covers various types of burn wound healing like skin and corneal burns, along with the alternative recent therapies being studied in the field of burn wound healing. The current reflection of the attitudes of people regarding the use of stem cells in burn wound healing is also stated.

Effectiveness of the adipose stem cells in burn wound healing: literature review

2021 ◽  
Author(s):  
Ahmad Oryan ◽  
Effat Alemzadeh ◽  
Esmat Alemzadeh ◽  
Maryam Barghi ◽  
Mohammad Zarei ◽  
...  
Keyword(s):  
Stem Cells ◽  
Wound Healing ◽  
Literature Review ◽  
Adipose Stem Cells ◽  
Burn Wound ◽  
Burn Wound Healing

scholarly journals Autologous and not allogeneic adipose-derived stem cells improve acute burn wound healing

PLoS ONE ◽  
2018 ◽  
Vol 13 (5) ◽  
pp. e0197744 ◽  
Author(s):  
Yu-Wei Chang ◽  
Yi-Chia Wu ◽  
Shu-Hung Huang ◽  
Hui-Min David Wang ◽  
Yur-Ren Kuo ◽  
...  
Keyword(s):  
Stem Cells ◽  
Wound Healing ◽  
Adipose Derived Stem Cells ◽  
Burn Wound ◽  
Burn Wound Healing
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