scholarly journals Molecular genetic tests in survival factors in patients with NSCLC in the clinical practice of Kazakhstan

2021 ◽  
Author(s):  
Suriya Yessentayeva ◽  
Valeriy Makarov ◽  
Zhanna Kalmatayeva ◽  
Zhanar Zhakenova ◽  
Dauranbek Arybzhanov
Keyword(s):  
Clinical Practice ◽  
Molecular Genetic ◽  
Genetic Tests ◽  
Survival Factors

Diagnosis and Management of Cardiomyopathies – A Focus on Genetics, Cardiac Magnetic Resonance and Clinical Features

2011 ◽  
Vol 7 (3) ◽  
pp. 225
Author(s):  
Gianfranco Sinagra ◽  
Michele Moretti ◽  
Giancarlo Vitrella ◽  
Marco Merlo ◽  
Rossana Bussani ◽  
...  
Keyword(s):  
Clinical Practice ◽  
Cardiac Magnetic Resonance ◽  
Magnetic Resonance ◽  
Imaging Techniques ◽  
Molecular Genetic ◽  
Molecular Genetic Analysis ◽  
Routine Clinical Practice ◽  
Clinical Approach ◽  
Diagnosis And Management ◽  
Made In

In recent years, outstanding progress has been made in the diagnosis and treatment of cardiomyopathies. Genetics is emerging as a primary point in the diagnosis and management of these diseases. However, molecular genetic analyses are not yet included in routine clinical practice, mainly because of their elevated costs and execution time. A patient-based and patient-oriented clinical approach, coupled with new imaging techniques such as cardiac magnetic resonance, can be of great help in selecting patients for molecular genetic analysis and is crucial for a better characterisation of these diseases. This article will specifically address clinical, magnetic resonance and genetic aspects of the diagnosis and management of cardiomyopathies.

scholarly journals The optimal modeling method of specific tuberculosis peritonitis (experimental research)

2022 ◽  
Vol 99 (12) ◽  
pp. 44-50
Author(s):  
D. V. Plotkin ◽  
T. I. Vinogradova ◽  
M. N. Reshetnikov ◽  
Yu. R. Zyuzya ◽  
M. S. Serdobintsev ◽  
...  
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Experimental Research ◽  
Molecular Genetic ◽  
Modeling Method ◽  
Tuberculous Peritonitis ◽  
Internal Organs ◽  
Genetic Tests ◽  
Pathophysiological Mechanisms ◽  
Optimal Modeling

The objective: to create a reproducible model of chronic tuberculosis peritonitis to study pathophysiological mechanisms of its progression and to develop pathogenetically based therapy.Subjects and Methods. The study was performed using 10 male rabbits of the Chinchilla breed. The animals were administered intraperitoneal culture of Mycobacterium tuberculosis, tuberculosis peritonitis modeling was performed according to the proposed method.Results. In the course of the experiment, it was proved that all animals developed tuberculous peritonitis with lesions of the large omentum and serous integuments of internal organs. Molecular genetic tests of fragments of the omentum and peritoneum detected DNA of Mycobacterium tuberculosis.

scholarly journals Molecular genetic tests as a guide to surgical management of familial adenomatous polyposis

The Lancet ◽  
1996 ◽  
Vol 348 (9025) ◽  
pp. 433-435 ◽  
Author(s):  
HFA Vasen ◽  
RB van der Luijt ◽  
JFM Slors ◽  
E Buskens ◽  
P de Ruiter ◽  
...  
Keyword(s):  
Familial Adenomatous Polyposis ◽  
Surgical Management ◽  
Molecular Genetic ◽  
Adenomatous Polyposis ◽  
Genetic Tests

Molecular genetic tests in surgical management of familial adenomatous polyposis

The Lancet ◽  
1998 ◽  
Vol 351 (9109) ◽  
pp. 1131-1132
Author(s):  
D Gareth R Evans ◽  
James Hill ◽  
Tracey Dudding ◽  
John Burn ◽  
Eamonn R Maher
Keyword(s):  
Familial Adenomatous Polyposis ◽  
Surgical Management ◽  
Molecular Genetic ◽  
Adenomatous Polyposis ◽  
Genetic Tests

Molecular genetic tests in familial adenomatous polyposis may guide management decisions

2001 ◽  
Vol 120 (5) ◽  
pp. A121
Author(s):  
Iain George Beveridge ◽  
Chris J. Groves ◽  
Kay Neale ◽  
Robin K.S. Phillips
Keyword(s):  
Familial Adenomatous Polyposis ◽  
Molecular Genetic ◽  
Adenomatous Polyposis ◽  
Management Decisions ◽  
Genetic Tests

Molecular genetic tests in the prediction of the prognosis of breast cancer

2011 ◽  
Vol 4 (3) ◽  
Author(s):  
F. R. Stoddard ◽  
A. M. Szasz ◽  
B. Szekely ◽  
A.-M. Tokes ◽  
J. Kulka
Keyword(s):  
Breast Cancer ◽  
Molecular Genetic ◽  
Genetic Tests

scholarly journals Biomarkers of myocardial fibrosis and their genetic regulation in patients with heart failure

2020 ◽  
Vol 25 (10) ◽  
pp. 3933
Author(s):  
T. B. Pecherina ◽  
A. G. Kutikhin
Keyword(s):  
Heart Failure ◽  
Clinical Practice ◽  
Targeted Therapy ◽  
Myocardial Fibrosis ◽  
Molecular Genetic ◽  
Genetic Regulation ◽  
Controversial Subject ◽  
Patients With Heart Failure ◽  
Histological Confirmation ◽  
The Relationship

Currently, the development of chronic heart failure (CHF) is considered from the perspective of pathological structural remodeling of myocardium and fibrosis. Despite the widespread use of molecular genetic markers in clinical practice, only a small number of them are used to evaluate remodeling processes, as well as to predict potential complications associated with heart failure (HF). In addition, the relationship between many biomarkers with instrumental and histological confirmation of myocardial fibrosis has not yet been determined. Myocardial fibrosis remains quite debatable and controversial subject, which actualizes the further study of this direction. The discovery of pathogenetic and diagnostic markers of myocardial fibrosis could contribute to the development of targeted therapy. Of particular interest is the search for possible pathogenetic markers, since this is relevant for clinical practice.

scholarly journals Genetic researches in standards of delivery of health care

2018 ◽  
Vol 20 (1) ◽  
pp. 190-194
Author(s):  
V Yu Kravtsov ◽  
A I Solovev ◽  
I A Ivanov
Keyword(s):  
Health Care ◽  
Clinical Practice ◽  
Medical Care ◽  
Molecular Genetic ◽  
Hereditary Diseases ◽  
Medical Services ◽  
Genetic Diagnostics ◽  
Parasitic Diseases ◽  
Causative Agents ◽  
Molecular Genetic Diagnostics

The analysis of legal base of genetic researches in clinical practice is carried out. Modern standards of medical care are analyzed. The list of the diseases and pathological states demanding performance of genetic researches is made. The list of the medical services connected with genetic researches is also made. It is shown, that genetic researches make 10% of the nomenclature of medical services. From them about 60% medical services provide diagnosis of somatic pathology, the others are directed to identification of nucleinic acids of causative agents of infectious and parasitic diseases. Genetic researches are carried out mainly at a stage of specialized and primary medical care. Genetic researches are included in20% of standards of medical care. Genetic researches are conducted concerning 15 classes of diseases. More often genetic researches are conducted for diagnosis of the latent infections, enzimopatiya, hereditary diseases of a metabolism, and also cancer. There are some problems of cytogenetic and molecular genetic diagnostics in hospitals. Genetic researches are complex and expensive. Interpretation of the received results is difficult. It is necessary to develop standards of genetic researches. It is necessary to improve legal base of genetic researches.

scholarly journals Effectiveness of immunosuppressive therapy for lymphocytic myocarditis according: data from actual clinical practice

2021 ◽  
Vol 26 (11) ◽  
pp. 4696
Author(s):  
S. V. Mairina ◽  
V. A. Titov ◽  
L. B. Mitrofanova ◽  
E. S. Pavlova ◽  
M. A. Bortsova ◽  
...  
Keyword(s):  
Heart Failure ◽  
Clinical Practice ◽  
Immunosuppressive Therapy ◽  
Molecular Genetic ◽  
Molecular Genetic Analysis ◽  
Actual Clinical Practice ◽  
Therapy Regimen ◽  
Persistent Viral Infection ◽  
Contrast Enhanced ◽  
Lymphocytic Myocarditis

Aim. To compare the effectiveness of standard heart failure therapy with and without combined immunosuppressive therapy in patients with documented lymphocytic myocarditis (LM) based on data from actual clinical practice.Material and methods. This observational study included 70 patients with documented LM, 40% (n=28) of whom received immunosuppressive therapy. All patients underwent standard echocardiographic and laboratory investigations, endomyocardial biopsy with histological, immunohistochemical and molecular genetic analysis. Contrast-enhanced cardiac magnetic resonance imaging was performed in 74% of patients. All patients received standard therapy for heart failure at baseline.Results. The groups did not differ in demographic and echocardiographic characteristics. The appointment of immunosuppressive therapy was accompanied by an increase in ejection fraction by 12,2% compared to 6,4% (p=0,02). There were no significant differences in combined endpoints (survival and the need for heart transplantation) depending on therapy regimen (log-rank p=0,97).Conclusion. The prognosis of patients with chronic LM depends on the process activity, the severity of impaired hemodynamics and ventricular arrhythmias, as well as on the presence of persistent viral infection. Compliance with patient selection algorithm before prescribing immunosuppressive therapy is associated with the improvement in myocardial global contractility.

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