scholarly journals 十枣汤治疗肝硬化腹水临证谈[Discussion on the clinical use of Shi Zao Tang (Ten Jujubes Decoction)]

2020 ◽  
pp. 1-4
Author(s):  
Jun Yu He
Keyword(s):  
Liver Cirrhosis ◽  
Chinese Medicine ◽  
Correct Diagnosis ◽  
Clinical Use

Abstract Ascites is a common dangerous and lethal complication of the liver cirrhosis. In Chinese Medicine, the ascites due to the liver cirrhosis belongs to Gu Zhang i.e. drum distention, which can be treated by Shi Zao Tang (Ten Jujubes Decoction). Although the Shi Zao Tang with Wan Yua (Flos Genkwa), Gan Sui (Radix Kansui), and Da Ji (Radix Euphorbiae Pekinensis) drastically purging and expel water, the herbs are toxic, which must be restrained by the proper use of Da Zao (Fructus Jujube). Additionally, Gu Zhang is characterized by deficient Ben-root and excess Biao-branch. Therefore, clinical attention should be given to carefully neutralize the toxicity of the three herbs, based on the correct diagnosis of the Ben-root and Biao -branch. 【摘 要】腹水是肝硬化最常见的并发症之一，严重威胁患者的健康和生命。肝硬化腹水属于中医“臌胀”的范畴，可运用十枣汤峻下逐水。但需要注意的是芫花、甘遂、大戟药性峻猛有毒，需合理配伍大枣减轻毒性。此外臌胀属于本虚标实之症，临证需要注意：稳中求效、避免攻邪伤正，用药谨守法度、把握“衰其大半而止”的原则，尊古不泥古、灵活变通、中西医结合，辨证求因、谨守病机、治病求本。

scholarly journals Effects of Shaoyao-Gancao-Fuzi Decoction on the Pharmacokinetics of CYP3A4-Mediated Tofacitinib in Rats

2020 ◽  
Author(s):  
Li Lin ◽  
Yuan Wang ◽  
Sennan Shao ◽  
Wen Lin ◽  
Dan Huang ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Oral Administration ◽  
Western Medicine ◽  
Control Group ◽  
Clinical Use ◽  
Pharmacokinetic Profiles ◽  
Pre Treatment ◽  
Cocktail Approach

Abstract Background: The combination of traditional Chinese medicine and western medicine is commonly accepted in clinics in China. Shaoyao-Gancao-Fuzi decoction (SGFD) has been extensively used to dispel wind, eliminate dampness and treat paralysis. Tofacitinib is approved for the treatment of rheumatoid arthritis. SGFD and tofacitinib could be used together for the treatment of rheumatoid arthritis.Methods: A cocktail approach was employed to assess the effects of SGFD on the activities of CYP450s. After pretreatment for 2 weeks with SGFD, a cocktail solution was given to rats 24 h after the last dose of saline or SGFD. Additionally, the pharmacokinetic profiles of oral administration of tofacitinib in rats, with or without SGFD pre-treatment were investigated.Results: The results showed that SGFD could induce the activity of CYP1A2 and inhibit the activity of CYP3A4. Furthermore, SGFD could significantly affect the pharmacokinetics of tofacitinib. Compared with control group, the AUC0-∞ of tofacitinib was increased from 13669.53 ± 4986.83 to 28706.69 ± 9563.13 ng/mL*h (p < 0.01), and the Cmax was increased from 8359.66 ± 1512.22 to 11332.51 ± 2791.90 ng/mL (p < 0.05).Conclusions: The system exposure of tofacitinib was increased by SGFD. The mechanism might be through inhibiting the activity of CYP3A4 and reducing the metabolism of tofacitinib in rats. The study will provide better guidance for the safe clinical use of SGFD and tofacitinib.

scholarly journals YinQiSanHuang Jiedu decoction for the treatment of hepatitis B-related compensated liver cirrhosis: study protocol for a multicentre randomised controlled trial.

2021 ◽  
Author(s):  
Qing-Juan Wu ◽  
Wen-Liang Lv ◽  
Juan-Mei Li ◽  
Ting-Ting Zhang ◽  
Wen-Hui Zhou ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Cirrhosis ◽  
Placebo Group ◽  
Chinese Medicine ◽  
Randomised Controlled Trial ◽  
Traditional Chinese Medicine ◽  
Liver Fibrosis ◽  
Hepatitis B ◽  
Controlled Trial ◽  
Randomised Controlled

Abstract Introduction: Hepatitis B-related compensated liver cirrhosis is related to higher risk of hepatocellular carcinoma, anti-viral therapy is the preferred method. As the pathological mechanisms of liver fibrosis are complex, drugs developed for a single target are difficult to be effective in clinical practice, so there are no chemical drugs or biological drugs with clear efficacy available for clinical application at present. Traditional Chinese medicine is a kind of medical science that has been gradually formed during thousands of years and continuously enriched by the people of all ethnic groups in China. Traditional chinese medicine shows curative effects in the treatment of liver diseases, especially in the field of liver fibrosis prevention and treatment. This study aim to test the integrative medicine (chinese medicine plus anti-riral therapy) effective on lowing hepatocellular carcinoma risk among patients with hepatitis B-related compensated liver cirrhosis.Methods and Analysis: This is a multicentre randomised controlled trial, total 5 hospitals and 802 patients will involved in. All the subjects are randomly allocated to the YinQiSanHuang Jiedu decoction(YQSHD) group (n=401) or the placebo group (n=401). The YQSHD group receives YQSHD granule with Entecavir(ETV), the placebo group receives YQSHD placebo with ETV. Treatment period will last for 52 weeks, and follow-up period for 52±2 weeks. The primary outcome measure is the annual incidence of HCC. Outcomes will be assessed at baseline and after treatment. Objective of this trial is “the integrative of YQSHD with ETV reduce the annual incidence of HCC to 1%”.Ethics and dissemination:The protocol has been approved by the Medical Ethics Committee of Guang’anmen Hospital, China (No.2019-006-KY), and the other centres in the trial will not begin recruiting until local ethical approval has been obtained.Trial final results will be disseminated via publication. Trial registration: ChiCTR1900021532, this protocol was registered in the Chinese Clinical Trial Registry (URL: http://www.chictr.org.cn/searchproj.aspx) on February 26th, 2019.

Deer antlers: traditional Chinese medicine use and recent pharmaceuticals

2020 ◽  
Vol 60 (10) ◽  
pp. 1233 ◽  
Author(s):  
Chunyi Li
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Functional Food ◽  
Clinical Use ◽  
Living Tissue ◽  
Medicine Use ◽  
Large Size ◽  
Biological Phenomena ◽  
Traditional Remedy ◽  
Dead Tissue

Deer velvet antlers (VA) have been used as a type of traditional Chinese medicine for over 2000 years, mainly for treating yang-deficiency syndromes. However, VA still largely remain a traditional remedy with scant science, although getting more attention as time goes. In recent years, our group has been trying to develop some efficacious drugs/functional food based on unique biological phenomena of VA, such as, for example, dead tissue (hard antler base) being attached to living tissue (pedicle) for over half a year without causing inflammation, a large-size wound (up to 10 cm in diameter) being left on top of a pedicle stump after previous antler casting healing within a week only with a negligible scar, and severely osteoporotic skeleton caused by intensive antler calcification fully reversing after the completion of antler calcification. Successful translation of these unique phenomena to clinical use would greatly benefit human health.

scholarly journals Do Different Species of Sargassum in Haizao Yuhu Decoction Cause Different Effects in a Rat Goiter Model?

2019 ◽  
Vol 2019 ◽  
pp. 1-13
Author(s):  
Dianna Liu ◽  
Feng Chen ◽  
Xue Yu ◽  
Linlin Xiu ◽  
Haiyan Liu ◽  
...  
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Thyroid Hormones ◽  
Thyroid Tissue ◽  
Serum Levels ◽  
Thyroid Stimulating Hormone ◽  
Clinical Use ◽  
Pathological Changes ◽  
Sargassum Fusiforme ◽  
Sargassum Pallidum

Sargassum species combined with Glycyrrhiza uralensis is a famous herbal pair in traditional Chinese medicine, as one of the so-called “eighteen antagonistic medicaments.” In the Chinese Pharmacopoeia, two different species of Sargassum, Sargassum pallidum and Sargassum fusiforme, are recorded but they are not clearly differentiated in clinical use. In this study, we aimed to determine whether the two species of Sargassum could result in different effects when combined with G. uralensis in Haizao Yuhu Decoction (HYD), which is used for treating thyroid-related diseases, especially goiter. HYD containing S. pallidum or S. fusiforme was administered to rats with propylthiouracil-induced goiter. After 4 weeks, pathological changes in the thyroid tissue and the relative thyroid weight indicated that HYD containing S. pallidum or S. fusiforme protected thyroid tissues from propylthiouracil damage. Neither species increased the propylthiouracil-induced decrease in serum levels of thyroid hormones. However, there were some differences in their actions, and only HYD containing S. fusiforme abated the propylthiouracil-induced elevation of serum thyroid-stimulating hormone levels and activated thyroglobulin mRNA expression.

scholarly journals Long-Term Traditional Chinese Medicine Combined with NA Antiviral Therapy on Cirrhosis Incidence in Chronic Hepatitis B Patients in the Real-World Setting: A Retrospective Study

2020 ◽  
Vol 2020 ◽  
pp. 1-8
Author(s):  
Zhi-Jun Hou ◽  
Jing-Hao Zhang ◽  
Xin Zhang ◽  
Qi-Hua Ling ◽  
Chao Zheng ◽  
...  
Keyword(s):  
Liver Cirrhosis ◽  
Chronic Hepatitis ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Hepatitis B ◽  
Antiviral Therapy ◽  
Chronic Hepatitis B ◽  
Cumulative Incidence ◽  
Histological Evaluation

Objective. To evaluate the impact of long-term Traditional Chinese Medicine (TCM) syndrome differentiation combined with antiviral therapy with Nucleos (t) ide analogues (NAs) on the incidence of cirrhosis in patients with chronic hepatitis B. Methods. This retrospective cohort study included 521 patients with chronic hepatitis B who underwent a treatment course of ≥3 years from 1998–2019. Of the 521 patients, 261 were defined as TCM users while 260 were TCM nonusers (control group). All the enrolled subjects were followed up until February 2019 to measure the incidence and hazard ratio (HR) of cirrhosis, and the Cox proportional hazards regression model was used to analyze the independent factors affecting the occurrence of cirrhosis. Results. The cumulative incidence of TCM users and nonusers was 6.9% and 13.5%, respectively (P=0.013). Results of the Kaplan–Meier analysis demonstrated that TCM users had a significantly lower cumulative incidence of cirrhosis than TCM nonusers (P=0.011), and TCM users had a significantly lower liver cirrhosis risk than TCM nonusers (adjusted HR = 0.416, 95% CI, 0.231–0.749). The histological evaluation revealed improved fibrosis in 45.0% of TCM users and 11.1% of TCM nonusers (P=0.033). The analysation of the prescriptions including total 119 single Chinese herbs medicinal demonstrated that “replenish qi and fortify the spleen,” “clear heat and dispel dampness,” and “soothe the liver and regulate qi” are the main treatment methods of TCM for CHB. Conclusions. Our study demonstrated that long-term TCM use may attenuate liver cirrhosis risk in patients with chronic hepatitis B (CHB).

scholarly journals Comparative Efficacy and Toxicity of Different Species of Sargassum in Haizao Yuhu Decoction in PTU-Induced Goiter Rats

2017 ◽  
Vol 2017 ◽  
pp. 1-10 ◽  
Author(s):  
Linlin Xiu ◽  
Gansheng Zhong ◽  
Dianna Liu ◽  
Shaohong Chen ◽  
Haiyan Liu ◽  
...  
Keyword(s):  
Gene Expression ◽  
Chinese Medicine ◽  
Side Effects ◽  
Underlying Mechanism ◽  
Clinical Use ◽  
Comparative Efficacy ◽  
Safety And Efficacy ◽  
Sargassum Fusiforme ◽  
Sargassum Pallidum ◽  
Hpt Axis

Background. Haizao Yuhu Decoction has been widely used to treat thyroid-related diseases especially goiter with few side effects in traditional Chinese medicine (TCM), including herb pair Sargassum (HZ) and Glycyrrhizae Radix et Rhizoma (GC), as one of “eighteen antagonistic medicaments.” The two different species of Sargassum, Sargassum fusiforme (Sf) and Sargassum pallidum (Sp), are not clearly differentiated in clinical use, so that herb pair Sf-GC and Sp-GC could show different effect and toxicity. Methods. We investigated the antigoitrous effect and toxicity and clarified the potential underlying mechanism of the two different species of Sargassum in HYD (HYDf and HYDp) in PTU-reduced goiter rats. Results. The results demonstrated that both HYDf and HYDp could exhibit antigoitrous effect through alterations in hypothalamus-pituitary-thyroid (HPT) axis and inhibition of the TPO gene expression; there is no difference in the antigoitrous effects between the two different species of Sargassum application in HYD. Conclusion. This study evaluated the safety and efficacy of herb pair HZ-GC applied in HYD in goiter rats at molecular, cellular, and whole level and compared the two species of Sargassum further. We provide a reliable way to clarify the possible mechanism of the antagonistic medicament herb pair HZ-GC for its application.

scholarly journals A metabolic mechanism analysis of Fuzheng-Huayu formula for improving liver cirrhosis with traditional Chinese medicine syndromes

2017 ◽  
Vol 39 (6) ◽  
pp. 942-951 ◽  
Author(s):  
Ya-nan Song ◽  
Jian Chen ◽  
Fei-fei Cai ◽  
Yi-yu Lu ◽  
Qi-long Chen ◽  
...  
Keyword(s):  
Liver Cirrhosis ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Mechanism Analysis ◽  
Metabolic Mechanism
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