scholarly journals Drug delivery via super-paramagnetic (N2)n[SiO2(OH)2]8 Core-Shell catalyst

2020 ◽  
Vol 11 (30) ◽  
pp. 364-381
Author(s):  
Somayeh Khosravi ◽  
Majid Monajjemi ◽  
Ali Shamel
Keyword(s):  
Drug Delivery ◽  
Particle Size ◽  
Composite Particle ◽  
Hyperfine Interactions ◽  
Molecular Mechanic ◽  
Significant Loss ◽  
Core Shell ◽  
Chemical Shielding ◽  
Orientation Function ◽  
Vector Orientation

The MNPs @ [SiO2(OH)2]8 catalyzers were stablished via ab-initio and quantum mechanics & Molecular mechanic (QM/MM) simulation. The studies focus on how to improve the dispersion of composite particle for achieving high magnetic performances. The results revealed that the Fe3O4 @[SiO2 (OH)2]8(N2)8 as a cabalist exhibited better thermodynamic stability and dispersion than the magnetite nanoparticles. Furthermore, the particle size and magnetic properties of the [SiO2 (OH)2]8(N2)8 composite nanoparticles can be controlled by changing the functional groups. The electrical properties such as NMR Shielding, electron densities, energy densities, potential energy densities, ELF, LOL, of electron density, eta index, ECP, ESR and hyperfine interactions for Fe3O4@ [SiO2(OH)2]8(N2)8 have been calculated. As the catalyst could be easily recovered by magnetic separation and recycled for a few times without significant loss of its catalytic activity, we have calculated to obtain the stronger non bonded interaction in the Fe3O4@ [SiO2(OH)2]8(N2)8 system. This system can be used for antibiotics drug delivery instead of injection. The chemical shielding and several factors as the same electronegativity, magnetic anisotropy of π-systems will be changed due to the number of electrons The chemical shielding is a vector orientation function for all of the shielding parameters that can change in several places inside the shielding region.

Pluronic-Based Core/Shell Nanoparticles for Drug Delivery and Diagnosis

2013 ◽  
Vol 20 (28) ◽  
pp. 3488-3499 ◽  
Author(s):  
Yon Jung ◽  
Hwanbum Lee ◽  
Jae Kim ◽  
Eun Koo ◽  
Keun Oh ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Core Shell ◽  
Shell Nanoparticles ◽  
Core Shell Nanoparticles

Formulating SLN and NLC as Innovative Drug Delivery Systems for Non-Invasive Routes of Drug Administration

2020 ◽  
Vol 27 (22) ◽  
pp. 3623-3656 ◽  
Author(s):  
Bruno Fonseca-Santos ◽  
Patrícia Bento Silva ◽  
Roberta Balansin Rigon ◽  
Mariana Rillo Sato ◽  
Marlus Chorilli
Keyword(s):  
Drug Delivery ◽  
Particle Size ◽  
Drug Release ◽  
Drug Loading ◽  
Average Particle Size ◽  
Delivery Systems ◽  
Average Particle ◽  
Minor Importance ◽  
Routes Of Administration ◽  
Non Invasive

Colloidal carriers diverge depending on their composition, ability to incorporate drugs and applicability, but the common feature is the small average particle size. Among the carriers with the potential nanostructured drug delivery application there are SLN and NLC. These nanostructured systems consist of complex lipids and highly purified mixtures of glycerides having varying particle size. Also, these systems have shown physical stability, protection capacity of unstable drugs, release control ability, excellent tolerability, possibility of vectorization, and no reported production problems related to large-scale. Several production procedures can be applied to achieve high association efficiency between the bioactive and the carrier, depending on the physicochemical properties of both, as well as on the production procedure applied. The whole set of unique advantages such as enhanced drug loading capacity, prevention of drug expulsion, leads to more flexibility for modulation of drug release and makes Lipid-based nanocarriers (LNCs) versatile delivery system for various routes of administration. The route of administration has a significant impact on the therapeutic outcome of a drug. Thus, the non-invasive routes, which were of minor importance as parts of drug delivery in the past, have assumed added importance drugs, proteins, peptides and biopharmaceuticals drug delivery and these include nasal, buccal, vaginal and transdermal routes. The objective of this paper is to present the state of the art concerning the application of the lipid nanocarriers designated for non-invasive routes of administration. In this manner, this review presents an innovative technological platform to develop nanostructured delivery systems with great versatility of application in non-invasive routes of administration and targeting drug release.

NIR-triggered drug delivery system based on Fe3O4-MoS2 core-shell grafted poly(N-vinylcaprolactam): isotherm and kinetics studies

2021 ◽  
pp. 1-15
Author(s):  
Mohammad Javad Khodabakhshi ◽  
Homayon Ahmad Panahi ◽  
Elaheh Konoz ◽  
Alireza Feizbakhsh ◽  
Salimeh Kimiagar
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Core Shell ◽  
Kinetics Studies

scholarly journals Synthesis and Advanced Characterization of Polymer-Protein Core-Shell Nanoparticles

Catalysts ◽  
2021 ◽  
Vol 11 (6) ◽  
pp. 730
Author(s):  
Erik Sarnello ◽  
Tao Li
Keyword(s):  
Particle Size ◽  
Small Angle ◽  
Core Shell ◽  
Assembly Process ◽  
Shell Nanoparticles ◽  
X Ray ◽  
X Ray Scattering ◽  
Wide Range ◽  
Core Shell Nanoparticles ◽  
Ray Scattering

Enzyme immobilization techniques are widely researched due to their wide range of applications. Polymer–protein core–shell nanoparticles (CSNPs) have emerged as a promising technique for enzyme/protein immobilization via a self-assembly process. Based on the desired application, different sizes and distribution of the polymer–protein CSNPs may be required. This work systematically studies the assembly process of poly(4-vinyl pyridine) and bovine serum albumin CSNPs. Average particle size was controlled by varying the concentrations of each reagent. Particle size and size distributions were monitored by dynamic light scattering, ultra-small-angle X-ray scattering, small-angle X-ray scattering and transmission electron microscopy. Results showed a wide range of CSNPs could be assembled ranging from an average radius as small as 52.3 nm, to particles above 1 µm by adjusting reagent concentrations. In situ X-ray scattering techniques monitored particle assembly as a function of time showing the initial particle growth followed by a decrease in particle size as they reach equilibrium. The results outline a general strategy that can be applied to other CSNP systems to better control particle size and distribution for various applications.

scholarly journals In Situ Synthesis of Core-Shell-Structured SiCp Reinforcements in Aluminium Matrix Composites by Powder Metallurgy

Metals ◽  
2021 ◽  
Vol 11 (8) ◽  
pp. 1201
Author(s):  
Xinghua Ji ◽  
Cheng Zhang ◽  
Shufeng Li
Keyword(s):  
Particle Size ◽  
Powder Metallurgy ◽  
Shell Structure ◽  
Ex Situ ◽  
Aluminium Matrix ◽  
Core Shell ◽  
Matrix Composites ◽  
Aluminium Matrix Composites ◽  
Core Shell Structure

SiCp reinforced aluminium matrix composites (AMCs), which are widely used in the aerospace, automotive, and electronic packaging fields along with others, are usually prepared by ex situ techniques. However, interfacial contamination and poor wettability of the ex situ techniques make further improvement in their comprehensive performance difficult. In this paper, SiCp reinforced AMCs with theoretical volume fractions of 15, 20, and 30% are prepared by powder metallurgy and in situ reaction via an Al-Si-C system. Moreover, a combined method of external addition and an in situ method is used to investigate the synergistic effect of ex situ and in situ SiCp on AMCs. SiC particles can be formed by an indirect reaction: 4Al + 3C → Al4C3 and Al4C3 + 3Si → 3SiC + 4Al. This reaction is mainly through the diffusion of Si, in which Si diffuses around Al4C3 and then reacts with Al4C3 to form SiCp. The in situ SiC particles have a smooth boundary, and the particle size is approximately 1–3 μm. A core-shell structure having good bonding with an aluminium matrix was generated, which consists of an ex situ SiC core and an in situ SiC shell with a thickness of 1–5 μm. The yield strength and ultimate tensile strength of in situ SiCp reinforced AMCs can be significantly increased with a constant ductility by adding 5% ex situ SiCp for Al-28Si-7C. The graphite particle size has a significant effect on the properties of the alloy. A criterion to determine whether Al4C3 is a complete reaction is achieved, and the forming mechanism of the core-shell structure is analysed.

scholarly journals A Gentle Sedimentation Process for Size-Selecting Porous Silicon Microparticles to Be Used for Drug Delivery Via Fine Gauge Needle Administration

Silicon ◽  
2020 ◽  
Author(s):  
Elida Nekovic ◽  
Catherine J. Storey ◽  
Andre Kaplan ◽  
Wolfgang Theis ◽  
Leigh T. Canham
Keyword(s):  
Drug Delivery ◽  
Particle Size ◽  
Porous Silicon ◽  
Particle Sizes ◽  
Size Distributions ◽  
Particle Agglomeration ◽  
Gas Generation ◽  
Intravitreal Drug Delivery ◽  
Median Diameter ◽  
Experimental Values

AbstractBiodegradable porous silicon (pSi) particles are under development for drug delivery applications. The optimum particle size very much depends on medical use, and microparticles can outperform nanoparticles in specific instances. Here we demonstrate the ability of sedimentation to size-select ultrasmall (1–10 μm) nanoporous microparticles in common solvents. Size tunability is quantified for 1–24 h of sedimentation. Experimental values of settling times in ethanol and water are compared to those calculated using Stokes’ Law. Differences can arise due to particle agglomeration, internal gas generation and incomplete wetting. Air-dried and supercritically-dried pSi powders are shown to have, for example, their median diameter d (0.5) particle sizes reduced from 13 to 1 μm and from 20 to 3 μm, using sedimentation times of 6 and 2 h respectively. Such filtered microparticles also have much narrower size distributions and are hence suitable for administration in 27 gauge microneedles, commonly used in intravitreal drug delivery.

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