scholarly journals Histopathological Analysis of Gastric Cancers in University of Ilorin Teaching Hospital: A 20-Year Review

2021 ◽  
Vol 4 (1) ◽  
pp. 85-95
Author(s):  
KA Suleiman ◽  
EAO Afolayan ◽  
OOK Ibrahim ◽  
A Ahmed ◽  
SK Abubakar-Akanbi
Keyword(s):  
Gastric Cancer ◽  
Late Presentation ◽  
Histopathological Analysis ◽  
Tubular Adenocarcinoma ◽  
Endoscopic Screening ◽  
Female Ratio ◽  
Gastric Cancers ◽  
Male Female Ratio ◽  
Alarm Features

Gastric cancer is a relatively common malignancy in Nigeria. Gastric cancer varies from region, being 4th to 20th in proportion to other malignancies. The symptom and signs are often non-specific with the early stages of the disease. This may be responsible for late presentation and poor prognosis. This is a 20-year retrospective analysis of 107 histopathologically confirmed gastric cancers in the department of pathology. This study aimed to analyze the Histopathological patterns of all the gastric cancer cases diagnosed in U.I.T.H Ilorin, over a twenty-year period. Gastric cancers were classified according to WHO 2010 and Lauren classification of gastric cancers. A total of 107 cases of gastric cancers diagnosed, that met the inclusion criteria, were analyzed with male: female ratio of 1.3:1 out of which epithelial malignancy accounted for 93.5% with tubular adenocarcinoma representing the commonest epithelial subtype. Epithelial malignancy is the commonest histological type in this area. Therefore, it is recommended that patients above 40 years with dyspepsia and other alarm features should undergo routine endoscopic screening.

Behaviors of adult stomach cancer: a retrospective study of 95 cases

2019 ◽  
Vol 7 (2) ◽  
pp. 163-151
Author(s):  
Richard G Dong ◽  
Meilan J Harris
Keyword(s):  
Gastric Cancer ◽  
Stomach Cancer ◽  
Tumor Tissue ◽  
Young Patients ◽  
Considerable Variability ◽  
Female Ratio ◽  
Aggressive Disease ◽  
Pathological Characteristics ◽  
Male Female Ratio ◽  
Md Anderson

Stomach cancer mostly affects older people and the average age of people when they are diagnosed is 69 years old. About 6 of every 10 people diagnosed with stomach cancer each year are 95 or older. Further, gastric cancer is an aggressive disease with nonspecific early symptoms. Its incidence and prognosis in young patients has shown considerable variability. To better understand gastric in these young patients, we revised 95 young patients aged <30 diagnosed with gastric cancer at MD Anderson Center from January 2008 through February 2013, including age at diagnosis, sex, tumor histology, ethnicity and type of treatment to demonstrate its specific clinical and pathological characteristics. The presented data show that 96.6% of tumor tissue histology was adenocarcinoma, male/female ratio was 1.1:1 and no significant relationship to the tobacco or alcohol used. Furthermore, the median survival time of these 95 patients was 5.8 months, 71.4% with late diagnosis and 41% has gastric family history. Further 49.6% with symptoms of ulcer that do not improve under adequate medical management. Our concluded is that adult gastric cancer exhibits different tumor behavior with delay diagnosis that affects the prognosis of the tumor.

scholarly journals SIMULTANEOUS INTERVENTIONS IN PATIENTS WITH COMPLICATED FORMS OF POSTOPERATIVE VENTRAL HERNIA AND ANTERIOR ABDOMINAL WALL DEFORMATIONS

2019 ◽  
Vol 26 (1) ◽  
pp. 88-93
Author(s):  
Oksana Yu. Gerbali ◽  
Aleksandr V. Kosenko
Keyword(s):  
Laparoscopic Cholecystectomy ◽  
Surgical Treatment ◽  
Abdominal Wall ◽  
Anterior Abdominal Wall ◽  
Female Ratio ◽  
Male Female Ratio ◽  
Wall Deformation ◽  
Ventral Hernias ◽  
Postoperative Intestinal Obstruction

The aim is to optimize the treatment of patients with postoperative ventral hernias, anterior abdominal wall deformations and cholelithiasis.Materials and methods. 36 patients with complicated forms of postoperative ventral hernias, anterior abdominal wall deformation and cholelithiasis aged 36–74 years, under the 12:24 male/ female ratio were studied. According to the classification of Toskin — Zhebrovsky, smallsized, medium-sized, extensive and gigantic hernias were observed in 3 (8.3%), 12 (33.3%), 15 (41.7%) and 6 (16.7%) patients, respectively. According to the SWR-classification, the hernia of the median, lateral and combined localization was observed in 14 (38.9%), 7 (19.4%) and 15 (41.7%) patients, respectively. All patients were operated. Both autoplastic and prosthetic techniques of operations were used. Various forms of the anterior abdominal wall deformation were eliminated with the help of abdominoplasty. Laparoscopic cholecystectomy was performed simultaneously in all patients.Results. Postoperative complications occurred in 11 (30.5%) patients, with persistent seroma prevailing (6–54.5% of patients). In 3 (27.2%) patients wound suppuration was observed, in 1 (9.1%) — early postoperative intestinal obstruction. Postoperative pneumonia was observed in one patient.Conclusion. Success in the surgical treatment of such patients is determined by whether an individualized differentiated approach was used in choosing the method of surgery and the management of patients in the postoperative period.

scholarly journals Histopathologic Features of 1000 Cholecystectomy Specimens

2020 ◽  
Vol 13 (10) ◽  
Author(s):  
Mahsa Ahadi ◽  
Tahmineh Mollasharifi ◽  
Behrang Kazeminezhad ◽  
Mitra Abdolahi ◽  
Amir Sadeghi ◽  
...  
Keyword(s):  
Invasive Carcinoma ◽  
Precancerous Lesions ◽  
Cholesterol Stone ◽  
Histopathological Analysis ◽  
Female Ratio ◽  
Gallbladder Diseases ◽  
Predominant Type ◽  
Male Female Ratio ◽  
One Year ◽  
Calculous Cholecystitis

Background: One of the most common gastrointestinal surgeries is cholecystectomy. Gallstones are the major causes of cholecystectomy and induce various histopathologic changes. Gallbladder carcinoma is rare with poor prognosis. Metaplasic changes in gallbladder epithelium are considered precancerous lesions. Objectives: This study aimed at revealing the spectrum of histopathological patterns of gallbladder diseases in cholecystectomy specimens. Methods: A total of 1004 gallbladder H & E stained slides of cholecystectomy specimens over one year were studied. Histopathological evaluation was done by 6 pathologists in terms of variables. Results: In our study, the male: female ratio was 1:2.1. The age of patients varied from 17 to 96 years with a mean age of 49.1 years. The mean age of patients with gallstones was 47.52 years and was more common in women. Cholesterol, pigmented, and mixed stones were reported in 58.36%, 39.03%, and 2.6% of gallstones, respectively. The most common histological morphology was chronic calculous cholecystitis (61.18%). The incidence of metaplasia and invasive carcinoma was 19.55% and 0.2%, respectively. Conclusions: In this study, histopathological analysis of gallbladder diseases in the cholecystectomy specimens revealed that chronic calculous cholecystitis was the most common histologic finding. Gallstones were found more commonly in women and cholesterol stone was the predominant type. Pyloric metaplasia was the most frequent type of metaplasia. The rate of invasive carcinoma is compatible with those reported in the literature. Routine histopathological analysis of the cholecystectomy specimens will help to detect incidental carcinoma and precursors of malignancy.

scholarly journals Post Operative Diagnosis of Early Gastric Cancer in a Low Risk Population and the Possibility of Risk Stratified Screening

2015 ◽  
Vol 12 (1) ◽  
pp. 32-37
Author(s):  
B Ghimire ◽  
YP Singh ◽  
S Timalsina
Keyword(s):  
Gastric Cancer ◽  
High Risk ◽  
Early Gastric Cancer ◽  
Screening Program ◽  
Tertiary Care ◽  
Survival Rates ◽  
University Teaching ◽  
University Hospital ◽  
Female Ratio ◽  
Gastric Cancers

Background Gastric cancer is the second commonest cause of cancer related mortality worldwide. Though its incidence is more in Eastern Asia, it is increasing in the South Asian subcontinent. The diagnosis of early gastric cancer (EGC) confined to the mucosa or submucosa, is an important concern due to a better outcome at this stage where five year survival rates could increase by 90 percent. Though mass screening is done in few countries, it has not been applied in developing countries like Nepal. Preoperative diagnosis of EGC is rare in Nepal. The aim of this study is to analyze the clinico-pathological features of postoperative cases of gastric cancer managed in a tertiary care university hospital of Nepal.Methods All patients with histological diagnosis of gastric cancer admitted in the Department of Surgery, Tribhuvan University Teaching Hospital, Kathmandu, Nepal during the three year period (September 2010 to August 2013) were analyzed retrospectively.Results Ninety two patients with endoscopic diagnosis of gastric cancers were admitted during the past three years. The mean age was 60 years ranging from 28 years to 85 years with the male to female ratio of 2.8:1. Five patients were younger than 40 years and all were in advanced stage. Thirty five percent of the patients belonged to Janajatis (Hill) community though they comprise only 23% of the population and about 65% of them belonged to an area involving 25% of the country.Seventy six cases were operated. Out of 92 patients, 4 patients were diagnosed as early gastric cancer postoperatively. All patients with early gastric cancer were above 50 years with CT Scan abdomen revealing focal thickening without lymphadenopathy.Conclusion Over the years, the incidence of gastric cancer is increasing in Nepal. Though 92% are advance gastric cancers, few have been diagnosed and treated early. A screening program in a country like Nepal with diverse ethnicity and difficult terrain might be helpful if it targets high risk people in high risk areas.Kathmandu University Medical Journal Vol.12(1) 2014: 32-37

scholarly journals Diagnosis of gastric carcinoma

2020 ◽  
Vol 23 (80) ◽  
pp. 20-22
Author(s):  
Marijana Jandrić-Kočić
Keyword(s):  
Gastric Cancer ◽  
Treatment Options ◽  
Gastric Wall ◽  
Histopathological Analysis ◽  
Tubular Adenocarcinoma ◽  
Average Survival ◽  
Cytologic Analysis ◽  
Abdominal Examination ◽  
Specific Symptoms

INTRODUCTION: Gastric cancer is the fourth most commonly diagnosed cancer in the world and the second most common cause of cancer mortality. Diagnosis requires histopathological analysis of tissue obtained by esophagogastroduodenoscopy or cytologic analysis of gastric wiping / flushing. CASE REPORT: Patient aged 55 years presents in a family medical clinic due to dyspeptic problems accompanied by weight loss, weakness and maladaptation present at six months. Physical examination present sensitivity to deep palpation in the epigastrium. Ultrasound abdominal examination neat, laboratory anemia present. The patient is referred for esophagogastroduodenoscopy, which corporally, on a small curve of the stomach, detects a large ulceration of the bottom covered with fibrin and detritus, femoral margins. Bioptate finding reveals the presence of ventriculi mixed adenocarcinoma (tubular adenocarcinoma cum poorly cohesive carcinoma). Computed tomography of the abdomen determines the visible thickening of the stomach in the region of small curvature in the area of dimension 110x 26 mm and a large number of individual lymph glands up to 8 mm in fat with a small curve of the stomach. A total gastrectomy with a lymphadenectomy is done at the request of the oncological consulium. The pathohistological finding after surgery is adenocarcinoma ventriculi gradus III, pT3N1Mx (small curve, part of the anterior and posterior gastric wall infiltrative, engages all layers of the wall, but does not infiltrate serosa, size 7x6 cm, R0L1V0Pn0). A re-examination of the oncology consilium indicates chemotherapy / radiotherapy in hospital conditions and thereafter 5-fluorouracil / leucovorin chemotherapy. CONCLUSION: In the absence of specific symptoms and screening and early detection capabilities, the highest number of gastric cancers is diagnosed at an advanced stage when the prognosis is poor (average survival is 24 months) and treatment options are limited. Identification of new biological / molecular markers in early diagnosis of gastric cancer would allow a better quality of life and longer survival of the diseased.

Early outcomes of robotic distal gastrectomy with D2 lymphadenectomy for gastric cancer at Binh Dan Hospital

2021 ◽  
Vol 11 (2) ◽  
Author(s):  
Vĩnh Hưng Trần ◽  
Keyword(s):  
Gastric Cancer ◽  
Da Vinci ◽  
Operating Time ◽  
Case Series ◽  
Viet Nam ◽  
Safe Procedure ◽  
Robotic Gastrectomy ◽  
Female Ratio ◽  
Male Female Ratio ◽  
Operative Staging

Abstract Introduction: Gastric cancer is one of the five most common malignancies in Vietnam and worldwide. Recently, robotic gastrectomy with lymphadenectomy has become a new trend in the treatment of gastric cancer. In Vietnam, we conducted this study to assess the safety and feasibility of this procedure. Patients and methods: Descriptive study with a case series enrolled 13 patients with lower third gastric cancer underwent gastrectomy with lymphadenectomy by Si-generation da Vinci robot at Binh Dan Hospital from 01/01/2017 to 31/07/2019. Results: Male/female ratio was 2.25:1. The median age was 56.92 ± 8.66 years old. The pre-operative staging (cTNM) was mostly stage III. Robot docking time was 15 ± 7.36 minutes. The total operating time was 225.38 ± 36.43 minutes. The average blood loss during surgery was 66.15 ± 23.64 ml. There were no intraoperative accident as well as early postoperative complication. The postoperative hospital stay was 7.62 ± 0.87 days. The total number of metastatic lymph nodes was 1.62 ± 1.61 nodes. The postoperative staging was IIIA (53.85%), IIB (23.08%), IIA (15.38%) and IB (7.69%) respectively. Conclusions: Robotic gastrectomy is a safe procedure with promising indexes during and after surgery. Key word: Gastric cancer, robotic surgery. Tóm tắt Đặt vấn đề: Ung thư dạ dày (UTDD) là một trong năm loại ung thư phổ biến nhất tại Việt Nam và trên thế giới. Phẫu thuật robot cắt dạ dày và nạo hạch trở thành xu hướng điều trị mới trong UTDD. Tại Việt Nam, chúng tôi tiến hành nghiên cứu sau để tìm hiểu tính an toàn và khả thi của phương pháp phẫu thuật này. Đối tượng và phương pháp nghiên cứu: Nghiên cứu mô tả hàng loạt ca: 13 trường hợp ung thư dạ dày 1/3 dưới được phẫu thuật bằng robot da Vinci thế hệ Si tại bệnh viện Bình Dân từ 01/01/2017 đến 31/7/2019. Kết quả: Tỉ lệ nam : nữ là 2,25 : 1. Độ tuổi trung bình là 56,92 ± 8,66 tuổi. Giai đoạn bệnh trước mổ (cTNM) đa số là giai đoạn III. Thời gian docking robot là 15 ± 7,36 phút. Thời gian mổ toàn bộ là 225,38 ± 36,43 phút. Lượng máu mất trong mổ là 66,15 ± 23,64 ml. Tỉ lệ tai biến và biến chứng sớm là 0%. Thời gian nằm viện sau mổ là 7,62 ngày ± 0,87 ngày. Tổng số hạch di căn là 1,62 ± 1,61 hạch. Giai đoạn bệnh sau mổ bao gồm IIIA (53,85%), IIB (23,08%), IIA (15,38%), IB (7,69%). Kết luận: Phẫu thuật bằng robot cắt dạ dày là một phương pháp phẫu thuật an toàn với các chỉ số trong mổ và sau mổ đầy khả quan. Từ khóa: Phẫu thuật robot, ung thư dạ dày.

Ultrastructural Localization Study of Carcinoembryonic Antigen (CEA) in Gastric Cancer: Immunoelectron Microscopic Observation

1990 ◽  
Vol 48 (3) ◽  
pp. 252-253
Author(s):  
Dong Yuming ◽  
Yang Guanglin ◽  
Wu Jifeng ◽  
Chen Xiaolin
Keyword(s):  
Gastric Cancer ◽  
Intestinal Metaplasia ◽  
Cancer Cells ◽  
Microscopic Observation ◽  
Biological Significance ◽  
Ultrastructural Localization ◽  
Mucinous Carcinoma ◽  
Surface Glycoprotein ◽  
Tubular Adenocarcinoma ◽  
Pap Method

On the basis of light microscopic observation, the ultrastructural localization of CEA in gastric cancer was studied by immunoelectron microscopic technique. The distribution of CEA in gastric cancer and its biological significance and the mechanism of abnormal distribution of CEA were further discussed.Among 104 surgically resected specimens of gastric cancer with PAP method at light microscopic level, the incidence of CEA(+) was 85.58%. All of mucinous carcinoma exhibited CEA(+). In tubular adenocarcinoma the incidence of CEA(+) showed a tendency to rising with the increase of degree of differentiation. In normal epithelia and intestinal metaplasia CEA was faintly present and was found only in the luminal surface. The CEA staining patterns in cancer cells were of three types--- cytoplasmic, membranous and weak reactive type. The ultrastructural localization of CEA in 14 cases of gastric cancer was studied by immunoelectron microscopic technique.There was a little or no CEA in the microvilli of normal epithelia. In intestinal metaplasia CEA was found on the microvilli of absorptive cells and among the mucus particles of goblet cells. In gastric cancer CEA was also distributed on the lateral and basal surface or even over the entire surface of cancer cells and lost their polarity completely. Many studies had proved that the alterations in surface glycoprotein were characteristic changes of tumor cells. The antigenic determinant of CEA was glycoprotein, so the alterations of tumor-associated surface glycoprotein opened up a new way for the diagnosis of tumors.

Suicide in Nógrád County, Hungary, 1970-1994

Crisis ◽  
1999 ◽  
Vol 20 (2) ◽  
pp. 64-70 ◽  
Author(s):  
Tamás Zonda
Keyword(s):  
High Risk ◽  
Psychiatric Disorders ◽  
Suicide Rate ◽  
Risk Groups ◽  
The Elderly ◽  
Female Ratio ◽  
Suicide Notes ◽  
Suicidal Intention ◽  
Male Female Ratio

The author examined completed suicides occurring over a period of 25 years in a county of Hungary with a traditionally low (relatively speaking) suicide rate of 25.8. The rates are clearly higher in villages than in the towns. The male/female ratio was close to 4:1, among elderly though only 1.5:1. The high risk groups are the elderly, divorced, and widowed. Violent methods are chosen in 66.4% of the cases. The rates are particularly high in the period April-July. Prior communication of suicidal intention was revealed in 16.3% of all cases. Previous attempts had been undertaken by 17%, which in turn means that 83% of suicides were first attempts. In our material 10% the victims left suicide notes. Psychiatric disorders were present in 60.1% of the cases, and severe, multiple somatic illnesses (including malignomas) were present in 8.8%. The majority of the data resemble those found in the literature.

CLINICAL, ENDOSCOPIC AND PATHOGICAL CHARACTERISTICS OF COLORECTAL CANCER AT DA NANG HOSPITAL FROM 2016 TO 2017

2018 ◽  
pp. 9-14
Author(s):  
Thanh Trung Nguyen ◽  
Duc Nhan Le ◽  
Van Xung Nguyen ◽  
Hieu Trung Doan
Keyword(s):  
Colorectal Cancer ◽  
Descriptive Study ◽  
Bloody Stool ◽  
Key Words Colorectal Cancer ◽  
Right Colon ◽  
Female Ratio ◽  
Histopathological Classification ◽  
Male Female Ratio ◽  
Female Male Female ◽  
Colorectal Cancer Patients

Objective: To study the clinical, endoscopy and pathogical characteristics of colorectal cancer at Da Nang Hospital. Methods: A retrospectively descriptive study, performed from 01/01/2016 to 31/12/2017 at Da Nang Hospital. Results: During two years, there were 205 cases of colorectal cancer patients hospitalized to Da Nang Hospital. Male: 59.51%, female: 40.49%, mean age: 65.8 ± 16.07. Male is higher than female, male/ female ratio is 1.4/1. The period from the first symptoms to admission < 3months predominated (83.8%). The predominant symptoms: Abdominal pain (85.85%), bloody stool (63.41%), defecation (62.44%), anemia (34.63%), weight loss (25.85%), fatigue (17.56%), abdominal distention (12.19%), nausea and vomiting (5.36%). Location of Lesions: Rectum (43.42%), sigmoid colon (20%), right colon (10.73%),cecum (10.73%), transverse colon (7.80%), left-colon (7.32%). Type of lesion on endoscopy: Exophytic (63.41%), ulceration-Exophytic (21.95%), ulceration (7.32%), polyp chemotherapy (7.32). Tumor size: ≥ 3/4 perimeter (39%), occupying the whole circumference (37.0%), occupying ≥ 1/2 perimeter (15.6%), accounting for 1/4 Perimeter (8.4%). The colon completely narrowed rate: 70.73%., incompletely was 29.27%. Histopathological classification: adenocarcinoma (85.85%), Mucinous adenocarcinoma: (9.27%) and non-differentiated epithelial carcinoma was 4.88%. Conclusion: Colorectal cancer was quite popular and was usually detected at advanced stages.Therefore, screening for subjects with risk factors for early detection and treatment is recommended. Key words: Colorectal cancer, endoscopy, pathogical characteristics...

CLINICAL FEATURES, INDICATIONS AND RESULT OF TRACHEOTOMY

2017 ◽  
pp. 50-55
Author(s):  
Duc Luu Ngo ◽  
Tu The Nguyen ◽  
Manh Hung Ho ◽  
Thanh Thai Le
Keyword(s):  
Clinical Features ◽  
University Hospital ◽  
Female Ratio ◽  
Tube Obstruction ◽  
Level Ii ◽  
Study Results ◽  
Male Female Ratio ◽  
Hospital Patients ◽  
Level I

Background: This study aims to survey some clinical features, indications and results of tracheotomy at Hue Central Hospital and Hue University Hospital. Patients and method: Studying on 77 patients who underwent tracheotomy at all of departments and designed as an prospective, descriptive and interventional study. Results: Male-female ratio was 4/1. Mean age was 49 years. Career: farmer 44.2%, worker 27.2%, officials 14.3%, student 7.8%, other jobs 6.5%. Respiratory condition before tracheotomy: underwent intubation 62.3%, didn’t undergo intubation 37.7%. Period of stay of endotracheal tube: 1-5 days 29.2%, 6-14 days 52.1%, >14 days 18.7%. Levels of dyspnea before tracheotomy: level I 41.4%, level II 48.3%, level III 0%, 10.3% of cases didn’t have dyspnea. Twenty cases (26%) were performed as an emergency while fifty seven (74%) as elective produces. Classic indications (37.7%) and modern indications (62.3%). On the bases of the site, we divided tracheostomy into three groups: high (0%), mid (25.3%) and low (74.7%). During follow-up, 44 complications occurred in 29 patients (37.7%). Tracheobronchitis 14.3%, tube obstruction 13%, subcutaneous empysema 10.4%, hemorrhage 5%, diffcult decannulation 5.2%, tube displacement 3.9%, canule watery past 2.6%, wound infection 1.3%. The final result after tracheotomy 3 months: there are 33 patients (42.9%) were successfully decannulated. In the 33 patients who were successfully decannulated: the duration of tracheotomy ranged from 1 day to 90 days, beautiful scar (51.5%), medium scar (36.4%), bad scar (12.1%). Conclusions: In tracheotomy male were more than female, adult were more than children. The main indication was morden indication. Tracheobronchitis and tube obstruction were more common than other complications. Key words: Tracheotomy

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