scholarly journals Evaluation of Standard Measurement Uncertainty From Method Validation Data for the ICP-OES Determination of Nb, Ta, Fe, Mn, Ti, Sn, Zr, and W in Niobite-Tantalite Samples

2019 ◽  
Vol 40 (5) ◽  
pp. 179-187
Author(s):  
V. Padmasubashini ◽  
V.V. Hanuman ◽  
S.B. Singh ◽  
S. Hamilton ◽  
M.B. Verma
Keyword(s):  
Measurement Uncertainty ◽  
Method Validation ◽  
Icp Oes ◽  
Validation Data ◽  
Standard Measurement

New advances in the method validation, extraction methods and measurement uncertainty for the determination of water-soluble hexavalent chromium in hydraulic cement

Talanta ◽  
2021 ◽  
Vol 232 ◽  
pp. 122286
Author(s):  
María Melania Ramírez-Quesada ◽  
Jimmy Venegas-Padilla ◽  
José Pablo Sibaja-Brenes ◽  
Bryan Calderón-Jiménez
Keyword(s):  
Measurement Uncertainty ◽  
Hexavalent Chromium ◽  
Method Validation ◽  
Extraction Methods ◽  
Water Soluble ◽  
Hydraulic Cement

scholarly journals Method Validation and Determination of Leachable Metals from Infusion and Transfusion Medical Devices

2021 ◽  
Author(s):  
Alexandra Schuh ◽  
Dirce Pozebon
Keyword(s):  
Method Validation ◽  
Medical Devices ◽  
Inductively Coupled Plasma ◽  
Optical Emission ◽  
Emission Spectrometry ◽  
Icp Oes ◽  
Inductively Coupled ◽  
Sample Extract ◽  
Plasma Optical Emission Spectrometry

This work deals with method validation for regulated metals (Cd, Pb, Ba, Sn, Cr and Cu) determination in infusion and transfusion medical devices. The investigated metals were extracted with water at (37 ± 1) °C followed by their determination in the extract by using inductively coupled plasma optical emission spectrometry (ICP-OES). The validated method was applied in the analysis of infusion and transfusion devices commercialized in Brazil to verify compliance with current legislation, which establishes that the sum of Pb, Ba, Sn, Cr and Cu in the extract must not exceed 1 mg L-1 and that of Cd must not 0.1 mg L-1. Samples from five manufacturers of infusion and transfusion devices, produced in Brazil or imported, were analysed. The results of the analysis showed that all devices complied with the legislation, whereas the sum of Pb, Ba, Sn, Cr and Cu concentrations and that of Cd in the extract were lower than the maximum permissible; Cd was not detected in any sample extract and the sum of the other elements was < 0.14 mg L-1 in all extracts of the analysed samples.

scholarly journals Standardisation of a European measurement method for the determination of anions and cations in PM2.5: results of field trial campaign and determination of measurement uncertainty

2016 ◽  
Vol 18 (12) ◽  
pp. 1561-1571
Author(s):  
Sonya Beccaceci ◽  
Richard J. C. Brown ◽  
David M. Butterfield ◽  
Peter M. Harris ◽  
René P. Otjes ◽  
...  
Keyword(s):  
Particulate Matter ◽  
Measurement Uncertainty ◽  
Field Trial ◽  
Measurement Method ◽  
Ambient Particulate Matter ◽  
European Standard ◽  
Standard Measurement ◽  
Anions And Cations ◽  
Determination Of Anions

The results of field trial campaign to validate the European standard measurement method for anions and cations in ambient particulate matter are presented.

Determination of Vitamin B12 in Infant Formula and Adult Nutritionals Using HPLC After Purification on an Immunoaffinity Column: First Action 2011.09

2012 ◽  
Vol 95 (4) ◽  
pp. 933-936 ◽  
Author(s):  
Ursula Kirchner ◽  
Katharina Degenhardt ◽  
Guenther Raffler ◽  
Maria Nelson
Keyword(s):  
Vitamin B12 ◽  
Measurement Uncertainty ◽  
Infant Formula ◽  
Potassium Cyanide ◽  
Immunoaffinity Column ◽  
Validation Data ◽  
Method Performance ◽  
Expert Review ◽  
Wide Range

Abstract During the “Standards Development and International Harmonization: AOAC INTERNATIONAL Mid-Year Meeting,” on June 29, 2011, the method “Determination of Vitamin B12 in Infant Formula and Adult Nutritionals Using HPLC After Purification on an Immunoaffinity Column” was recommended by an Expert Review Panel and adopted as AOAC Official First Action status. The method is applicable for the determination of vitamin B12 in milk-based infant formula. Vitamin B12 is extracted from the sample in sodium acetate buffer in the presence of potassium cyanide. After purification and concentration with an immunoaffinity column (IAC), vitamin B12 is determined by LC with UV detection (361 nm). Data supplied by CLF demonstrated linear response over a wide range of concentrations (1.4–39 μg/100 mL). The analytical range is 0.2–10 μg/100 g, depending on the capacity of the IACs (0.01–0.5 μg), the input weight, and dilutions. Recovery rates were assessed using National Institute of Standards and Technology SRM 1849, and determined to be 95.1%, with SD of 0.34 and CV of 9.0. Measurement uncertainty (UE) was 0.8 μg/100 g, which was calculated from the validation data. It is an expanded measurement uncertainty and was obtained through multiplication with a coverage factor k. LOQ values were reported as 0.10 μg/100 g. The performance characteristics of the method met the standard method performance requirements set forth by the AOAC Stakeholder Panel on Infant Formula and Adult Nutritionals; thus, the method was determined to be appropriate for First Action status.

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