scholarly journals REVIEW ON MEDOVAHASROTAS AND ITS MOOLSTHANA WITH REFERENCE TO OBESITY INDUCED HYPERTENSION

2021 ◽  
Vol 9 (4) ◽  
pp. 833-837
Author(s):  
Jinu K Mathew ◽  
Jaishree H Mhaisekar

Excess weight gain, especially when associated with increased visceral adiposity, is a major cause of hypertension accounting 65-75% of total cases of hypertension. Increased renal tubular sodium reabsorption by the impairment in renal pressure natriuresis plays an important role in initiating obesity induced hypertension. The present study conceptually tries to substantiate the relation between moolasthana described for medovahasrotas with reference to the pathology of obesity induced hypertension. The moola explained for medovahasrotas are Kati, Vrikka, Vapavahana and Mamsa (Kidney, Suprarenal gland, Lumbosacral region, Superficial fat) which are the general regions of deposition of visceral fat or meda. The increased meda will hamper the renal pressure natriuresis in mainly three ways: 1)Physical compression of the kidneys by fat in and around kidney. 2)Increased activation of RAAS. 3)Increased SNS activity. Thus, medovaha srotodushti further enhances medodhatudushti (Obesity or Sthoulyata) itself, which in turn destroys the srotomoola. Hence, evidence of inherent relation among medovaha srotas and its respective srotomoola is established. Keywords: Medovahasrotas, Srotomoola, obesity induced hypertension

Physiology ◽  
1996 ◽  
Vol 11 (6) ◽  
pp. 255-261 ◽  
Author(s):  
JE Hall ◽  
DH Zappe ◽  
M Alonso-Galicia ◽  
JP Granger ◽  
MW Brands ◽  
...  

Obesity is a major cause of human essential hypertension. Recent studies point toward increased renal tubular reabsorption and abnormal renal pressure natriuresis in mediating obesity hypertension. The mechanisms for these renal changes appear to be multifactorial, including activation of the sympathetic nervous system and altered intrarenal histology, which compresses the renal medulla.


2020 ◽  
Vol 35 (7) ◽  
pp. 2025-2034 ◽  
Author(s):  
Albert Do ◽  
Denise A. Esserman ◽  
Supriya Krishnan ◽  
Joseph K. Lim ◽  
Tamar H. Taddei ◽  
...  

2020 ◽  
Author(s):  
Abigail E Pine ◽  
Natasha A Schvey ◽  
Lisa M Shank ◽  
Natasha L Burke ◽  
M K Higgins Neyland ◽  
...  

ABSTRACT Introduction Adolescent military-dependents face unique psychosocial stressors due to their parents’ careers, suggesting they may be particularly vulnerable to excess weight gain and symptoms of depression and anxiety. Despite these risk factors, there is a lack of tested preventative interventions for these youths. Given the transient nature of military family deployments, research may be hindered due to difficulty in collecting long-term prospective outcome data, particularly measured height and weight. The primary aim of this study was to examine the feasibility and acceptability of collecting body mass index (BMI, kg/m2) outcome data up to 2 years following a randomized controlled pilot trial of an adapted interpersonal psychotherapy (IPT) program aimed at preventing excess weight gain and improving psychological functioning for adolescent military-dependents. In exploratory analyses, patterns in body composition over time were examined. Materials and Methods Twenty-seven adolescent military-dependent girls (baseline: Mage: 14.4 ± 1.6 years; MBMI: 30.7 ± 4.9 kg/m2; MBMI-z: 1.9 ± 0.4) participated in this study. After a baseline assessment, utilizing a computerized program to create a randomization string, girls were assigned to either an IPT or a health education (HE) program. Participants completed three follow-up visits (posttreatment, 1-year follow-up, and 2-year follow-up). Girls completed a Treatment Acceptability Questionnaire at posttreatment; at all time points, height and fasting weight were collected. For the primary aim, Fisher’s exact tests examined the rate of obtained follow-up data and lost to follow-up status between the two groups, Mann-Whitney U tests examined the session attendance between groups, and treatment acceptability ratings were compared between the two groups at posttreatment using an independent samples t-test. For the exploratory aim, one-way analyses of covariance (ANCOVAs) examined the group differences in BMI at each time point, adjusting for baseline values, and paired samples t-tests examined the within-group differences at each time point relative to baseline. Using imputed data in the full intent-to-treat sample, mixed model ANCOVAs were conducted to examine the group differences over time. Results Across both groups, girls attended an average of 72.0% of sessions. At least partial data were collected at posttreatment, 1-year follow-up, and 2-year follow-up for 96.3%, 85.2%, and 74.1% of the participants, respectively. There were no significant group differences in follow-up data collection rates, follow-up status, number of sessions attended, or treatment acceptability. BMI-z stabilized across groups, and there were no group differences in BMI-z. In adjusted ANCOVA models with imputed data, no significant group-by-time effects emerged. Conclusions For this randomized controlled prevention trial, long-term outcome data collection of measured BMI was possible in adolescent military-dependents and IPT was an acceptable and feasible intervention. An adequately powered trial is required to assess the efficacy of this intervention among military-dependents for obesity prevention and improvements in BMI.


Circulation ◽  
2018 ◽  
Vol 137 (suppl_1) ◽  
Author(s):  
Katherine H Ingram ◽  
Roxanna Lopez

An association between abdominal adiposity and insulin resistance is well-established. Recent research indicates that subcutaneous fat accumulation in the lower body may be associated with higher levels of insulin sensitivity. Hypothesis: This pilot study tested the hypothesis that the distribution of body fat in the lower body after pregnancy is negatively associated with gestational insulin resistance. Methods: In 32 nulliparous pregnant women (age 27±4.5, BMI 29.5±7.9, 69% non-hispanic white), the Homeostasis Model Assessment of Insulin Resistance (HOMA-IR) was computed from fasting glucose and insulin at 24-28 weeks gestation. Body composition was assessed at mid-gestation (18-20 weeks) and at four weeks post-partum. Total body fat was estimated via bioelectrical impedance (InBody 720) and skinfold thicknesses were measured at seven sites. Dual-energy xray absorptiometry (DXA) measures of regional fat (gynoid, visceral, and leg) were obtained post-partum only. Gestational weight gain was monitored by medical records. Partial correlation analyses were controlled for age and race and then analyses were repeated controlling for baseline (mid-gestation) body fat percent. HOMA-IR was log-transformed for normality. Results: HOMA-IR was associated with post-partum body fat ( r =0.45, p < .05) and adiposity in the trunk region ( r =0.58, 0.57 and 0.52 for DXA visceral fat, suprailiac skinfold, and abdominal skinfold, respectively, p < .01), but not with gestational weight gain ( r =.07, p = ns), DXA gynoid region ( r = 0.26, p = ns), or any other leg measure. When analyses were further controlled for baseline body fat, post-partum measures of lower-body adiposity were strongly and negatively correlated with HOMA-IR ( r = -0.66, -0.48, and -0.48 for thigh skinfold, DXA gynoid, and DXA leg, respectively, p < .05 for all). Neither DXA visceral fat ( r = .23; p = ns) nor any other post-partum fat measures were associated with HOMA-IR when controlling for baseline body fat. Conclusions: Gestational insulin resistance was negatively associated with post-partum thigh fat accumulation, independent of overall body fat. These data indicate that insulin sensitivity may be associated with the ability to store fat in the lower body and should warrant further study of subcutaneous leg fat as a metabolically “healthy” storage depot.


2018 ◽  
Vol 31 ◽  
pp. 120-124 ◽  
Author(s):  
Lauren E. Blau ◽  
Natalia C. Orloff ◽  
Amy Flammer ◽  
Carolyn Slatch ◽  
Julia M. Hormes

2009 ◽  
Vol 20 (8) ◽  
pp. 1724-1732 ◽  
Author(s):  
Arnold Sipos ◽  
Sarah L. Vargas ◽  
Ildikó Toma ◽  
Fiona Hanner ◽  
Klaus Willecke ◽  
...  

2011 ◽  
pp. P1-466-P1-466
Author(s):  
Cheryce L Harrison ◽  
Catherine B Lombard ◽  
Melanie Gibson-Helm ◽  
Amanda Deeks ◽  
Helena J Teede

Sign in / Sign up

Export Citation Format

Share Document