scholarly journals A CLINICAL STUDY TO EVALUATE THE SADYO SHOOLAHARA EFFECTIVENESS OF LAGHUPANCHAMOOLA KASHAYA WITH TRIVRUTH CHOORNAM IN GRIDHRASI (SCIATICA)

2021 ◽  
Vol 9 (8) ◽  
pp. 1717-1721
Author(s):  
Abhijith N ◽  
Ravindra Bhat K ◽  
Waheeda Banu
Keyword(s):  
Clinical Study ◽  
Severe Pain ◽  
Signs And Symptoms ◽  
Modern Medicine ◽  
Lumbar Region ◽  
Mild Improvement ◽  
Before And After ◽  
Effect Of Treatment ◽  
Calf Muscles

Gridhrasi is one among Vataja nanatmaja Vikara characterised by Sthabdhata, Ruk, Toda which radiates from buttock region, lumbar region, thigh, knee, calf muscles and legs. Gridhrasi is of two types viz Vataja and Vata Kaphaja Gridhrasi. Vataja Gridhrasi is characterized by severe pain and Vata Kaphaja Gridhrasi has symptoms viz Tandra, Gaurava and Aruchi. The signs and symptoms of Gridhrasi can be correlated to sciatica of modern medicine. Sciatica is characterized by constant aching pain felt in lumbar region which may radiate to the buttock, thigh, calf and foot and pain is experienced along the sciatic nerve pathway. It was a clinical study with a pre and post design in 30 patients who were diagnosed with Gridhrasi. After examination Laghupanchamoola Kashaya with trivruth choornam was given for 7 days. The assessment criteria were noted before and after treatment and on follow-up. Among the subjective and objective parameters, in the Overall effect of treatment in gridhrasi, out of 30 patients in this study, 15 patients (50%) got Mild effectiveness in shoola, and 15 patients (50%) got Moderate effectiveness in shoola. The overall effect of the treatment was 30.19%. Hence it can be concluded that Laghupanchamoola Kashaya with trivruth choornam is having mild improvement on symptoms of Gridhrasi and shows the long-lasting result. Keywords: Gridhrasi, Sciatica, Laghupanchamoola Kashaya, Trivruth choornam

scholarly journals A COMPARATIVE CLINICAL STUDY ON MATRA BASTI WITH SAHACHARADI TAILA AND VYOSADI TAILA IN GRIDHRASI W.S.R TO SCIATICA

2020 ◽  
Vol 8 (10) ◽  
pp. 4694-4700
Author(s):  
Vasudev R ◽  
Swathi S Deshpande
Keyword(s):  
Clinical Study ◽  
Signs And Symptoms ◽  
Modern Medicine ◽  
Lumbar Region ◽  
Common Condition ◽  
Lateral Flexion ◽  
Before And After ◽  
Comparative Clinical Study ◽  
Group A ◽  
Group B

Gridhrasi is one among Vatajananatmaja Vikara characterized by Sthabdhata, Ruk, Toda which radiates from buttock region, lumbar region, thigh, knee, calf muscles and legs. Gridhrasi is of two types viz Vataja and Vata Kaphaja Gridhrasi. Vataja Gridhrasi is characterized by severe pain and Vata Kaphaja Gridhrasi has symptoms viz Tandra, Gaurava and Aruchi. The signs and symptoms of Gridhrasi can be correlated to sciatica of modern medicine. Sciatica is characterized by constant aching pain felt in lumbar region which may radiate to the buttock, thigh, calf and foot and pain is experienced along the sciatic nerve pathway. It is a common condition with lifetime incidence varying from 13% to 40%. Matra Basti is indicated in dis-eases caused by vitiated Vata Doshas and thus considered as one of the treatments for Gridhrasi. It was a comparative clinical study with a pre and post design in 40 patients who were diagnosed with Gridhrasi, were assigned into 2 groups of 20 patients each randomly. After examination MatraBasti had given for group A with Vyoshadi Taila and group B with Sahacharadi Taila after Sthanika Abhyanga and Nad-isweda with respective oil for 7 days. The assessment criteria were noted before and after treatment and on followup. Among the subjective and objective parameters, Group A showed better reduction 51.47% in Ruk, Sthambha, Toda, Gaurava, active and passive SLR test, Bragard’s test and Lumbar movements. Group B does not have statistically significant over Gaurava, left lateral flexion and rotation to leave. Showed reduction 40.49% in Ruk, Sthambha, Toda active and passive SLR test and lumbar movement. Hence it can be concluded that MatraBasti with Vyosadi Tailam is having more effect on symptoms of Gridhrasi and shows long lasting result.

scholarly journals A comparative clinical study on the effect of Gudashunti Nasya and Kola Kulattadi Ruksha Sweda in Manyasthamba

2020 ◽  
Vol 5 (03) ◽  
pp. 1-6
Author(s):  
Sandeep K ◽  
Guruprasad G ◽  
Veeraj Hegde
Keyword(s):  
Statistical Analysis ◽  
Clinical Study ◽  
Severe Pain ◽  
Computer Usage ◽  
Before And After ◽  
Comparative Clinical Study ◽  
Group A ◽  
Group B ◽  
Classical Symptom

Due to present day lifestyle, a greater number of people are inclined to desk work and computer usage leading to many disorders. Manyasthamba is one among such disorders where the stiffness of neck with severe pain is the classical symptom which hampers our day to day life. While explaining treatment of Manyasthamba our Acharyas explained Rukshasweda and Nasya Karma as main line of treatment. Here a study was done by taking Gudashunti Yoga explained in Sharangadara Samhita indicated for Nasya and Kolakulattadi Churna indicated in Vatavyadhi explained in Ashtanga Sangraha for Ruksha Churna Sweda. A comparative clinical study of 40 patients suffering from Manyastambha were selected after thorough investigation. Patients were subjected to Nasya Karma in Group A and Ruksha Sweda and Nasya Karma in Group B for 7 days. Patients were assessed based on standard parameters before and after treatment and 7 days follow up. The statistical analysis revealed that there was a significant improvement in parameters like pain and stiffness. Hence proving the efficacy in the condition.

A Comparative Clinical Study on the effect of Ajmodadi Churna and Kati Basti in the management of Gridhrasi w.s.r. to Sciatica

2019 ◽  
Vol 4 (1) ◽  
Author(s):  
Akhilanath Parida ◽  
Satyasmita Jena
Keyword(s):  
Signs And Symptoms ◽  
Modern Medicine ◽  
Lumbar Region ◽  
Management Tools ◽  
Painful Condition ◽  
Choice Of Treatment ◽  
Comparative Clinical Study ◽  
Group A ◽  
Group B

In Ayurveda, Gridhrasi is considered as one of the Vataja Nanatmaja Vyadhi having vitiation of Vata and sometimes Vata Kapha Dosha. The cardinal signs and symptoms of Gridhrasi are Ruk (pain), Toda (pricking sensation), Stambha (stiffness) and Muhurspandan in the Sphika, Kati, Uruh, Janu, Jangha and Pada in order and Sakthiuthkshepanigraha (hinderence in lifting of the legs). In Kaphanubandha -Tandra, Gaurav, Arochaka are present. The signs and symptoms of ‘Gridhrasi’ can be correlated with that of ‘Sciatica’ in modern terminology. Sciatica is a very painful condition in which pain begins in lumbar region and radiates along the posterior lateral aspects of thigh and leg along with difficulty in walking. SLR test, sitting test, Lasegues sign are helpful not only to diagnose the sciatica but also to assess the progress of the therapy. With reference to the management of Sciatica, in modern medicine, various modalities are available. These modern therapies have their own limitations and these management tools are not affordable for the poor, especially in the developing countries. Therefore, the choice of treatment commonly opens to reveal some effective, simple, safe and economic modalities. Total 30 patients were registered in this study. 15 patients were assigned to group A (Ajmodadi Churna) and 15 to group B (Ajmodadi Churna and Sahacharadi Taila Kati Basti). Each patient was examined thoroughly before treatment and observed keenly during the procedure and follow up.

scholarly journals A COMPARATIVE CLINICAL STUDY ON MATRA BASTI WITH BALA TAILA AND SAHACHARA TAILA

2021 ◽  
Vol 9 (11) ◽  
pp. 2644-2651
Author(s):  
Yadukrishnan V. P ◽  
Praveen B. S
Keyword(s):  
Statistical Analysis ◽  
Clinical Study ◽  
Pain Score ◽  
Lower Limb ◽  
Severe Pain ◽  
Signs And Symptoms ◽  
The Body ◽  
Lumbar Region ◽  
Comparative Clinical Study ◽  
Good Improvement

Basti is said to be the best therapy for pacifying aggravated Vata Dosha. It is considered as Ardha Chikitsa due to the capacity to cure diseases of either Abhyantara, Bahya or Madhyama Roga Marga when used judiciously. It is broadly classified into Niruha, Anuvasana and Uttara Basti Anuvasana Basti believed to nourish the body and increase Bala (strength) and Varna (complexion). Matra Basti is a type of Anuvasana Basti in which the Sneha is administered in the lowest dosage. Gridhrasi is one among Vataja Nanatmaja Vikara characterised by Stabdhata (stiffness), Vedana (pain), Toda (pricking sensation) in the lumbar region radiating to the lower limb. Gridhrasi is of two types viz Vataja and Vata Kaphaja Gridhrasi. Vataja Gridhrasi is characterized by severe pain whereas, Vata Kaphaja Gridhrasi has symptoms viz Tandra (drowsiness), Gaurava (heaviness of body) and Aruchi (ano- rexia). Bala Taila contains Madhura Rasa, Snigdha, Vatahara, Balya, Brumhana properties. Sahachara Taila contains Madhura Tikta Rasa, Ushna Veerya and Vata-Kaphahara properties. This study was undertaken to com- pare the efficacy of Matra Basti with Bala Taila and Sahachara Taila in the management of Gridhrasi to ascer- tain a better modality. Statistical analysis showed that both groups showed good improvement in various parame- ters of Gridhrasi. When compared between the groups it revealed that there was not statistically difference except in S Lanss Pain Score (p<0.05). Hence it can be concluded that both Bala Taila Matra Basti and Sahachara TailaMatra Basti may be practiced in treating patients with Gridhrasi (Sciatica) to reduce both signs and symptoms successfully. Keywords: Matra Basti, Gridhrasi, Bala Taila, Sahachara Taila

Obesity management through Ayurveda - A Case Study

2017 ◽  
Vol 2 (4) ◽  
Author(s):  
Dheeraj Kumar Tyagi ◽  
Shivakumar .
Keyword(s):  
Clinical Findings ◽  
Dietary Habit ◽  
Unhealthy Lifestyle ◽  
Lifestyle Management ◽  
Before And After ◽  
Effect Of Treatment ◽  
And Control

Lifestyle disorders are one of the biggest threats for the population living unhealthy lifestyle. Sthoulya (Obesity) is one such disorder which creates lot of physical as well as mental disorder to the sufferer. Due to changing lifestyle, comforts and dietary habit lots of individuals changed their life totally. Obesity is a growing disease in developed and developing countries. Prevalence is drastically hike in past few years. Ayurveda, the science of life with which we can manage and control lots of lifestyle disorders. Focusing on dietary and lifestyle management along with treatment, we can overcome the hazards of obesity which is growing in a uncontrolled manner. The available data is based on the clinical findings only. Aim and objective: To assess the effect of “Guru Cha Atarpanam Chikitsa” in the management of Sthoulya. Setting: Swastharakshana evam Yoga, OPD and IPD, SDMCAH, Hassan. Method: Udwarthana, Parisheka, Shamana Aushadhis, Ahara, and Vihara was followed within the treatment duration and effect of treatment was assessed before and after treatment, advised for follow up. Results: The treatment adopted is effective in the management of Sthoulya and to improve the quality of life.

scholarly journals The Effect of Q-Switched Nd:YAG 1064 nm/532 nm Laser in the Treatment of Onychomycosis In Vivo

2013 ◽  
Vol 2013 ◽  
pp. 1-10 ◽  
Author(s):  
Kostas Kalokasidis ◽  
Meltem Onder ◽  
Myrto-Georgia Trakatelli ◽  
Bertrand Richert ◽  
Klaus Fritz
Keyword(s):  
Clinical Study ◽  
Treatment Time ◽  
Prospective Clinical Study ◽  
Self Evaluation ◽  
Time Period ◽  
Level Of Satisfaction ◽  
Before And After ◽  
532 Nm

In this prospective clinical study, the Q-Switched Nd:YAG 1064 nm/532 nm laser (Light Age, Inc., Somerset, NJ, USA) was used on 131 onychomycosis subjects (94 females, 37 males; ages 18 to 68 years). Mycotic cultures were taken and fungus types were detected. The laser protocol included two sessions with a one-month interval. Treatment duration was approximately 15 minutes per session and patients were observed over a 3-month time period. Laser fluencies of 14 J/cm2were applied at 9 billionths of a second pulse duration and at 5 Hz frequency. Follow-up was performed at 3 months with mycological cultures. Before and after digital photographs were taken. Adverse effects were recorded and all participants completed “self-evaluation questionnaires” rating their level of satisfaction. All subjects were well satisfied with the treatments, there were no noticeable side effects, and no significant differences were found treating men versus women. At the 3-month follow-up 95.42% of the patients were laboratory mycologically cured of fungal infection. This clinical study demonstrates that fungal nail infections can be effectively and safely treated with Q-Switched Nd:YAG 1064 nm/532 nm laser. It can also be combined with systemic oral antifungals providing more limited treatment time.

scholarly journals AB0571 IS RITUXIMAB AN ADEQUATE GLUCOCORTICOID SPARING AGENT IN IDIOPATHIC INFLAMMATORY MYOPATHIES?

2020 ◽  
Vol 79 (Suppl 1) ◽  
pp. 1582.1-1582
Author(s):  
B. H. Egeli ◽  
S. Ergun ◽  
Y. K. Gursoy ◽  
A. Cetin ◽  
S. Ugurlu
Keyword(s):  
Disease Activity ◽  
Alternative Treatment ◽  
Statistical Power ◽  
Signs And Symptoms ◽  
Small Sample ◽  
Idiopathic Inflammatory Myopathies ◽  
Inflammatory Myopathies ◽  
Treatment Methods ◽  
Before And After

Background:Idiopathic inflammatory myopathies (IIM) are essentially treated aiming improvement of muscle function and extra muscular disease manifestations. The backbone of the treatment is corticosteroids enhancing the survival and patient quality of life. The lack of consensus on target-specific immunosuppressive treatment highlights the need for further studies evaluating alternative treatment methods. Rituximab is potentially a glucocorticoid-sparing agent which was reviewed in multiple studies with small sample sizes due to the rarity of the disease.Objectives:Higher statistical power can enhance the trustworthiness of alternative treatment methods yielding the main objective of this study.Methods:This retrospective study was conducted at a tertiary rheumatology center. Patients were diagnosed with an idiopathic inflammatory myopathy (dermatomyositis [DM], polymyositis [PM]) and were treated with rituximab in order to be included in this study. Clinical signs and symptoms of the presentation were noted during the first patient encounter as well as the follow-up. Parameters of disease activity including acute phase reactants, muscle enzyme levels, and disease-specific autoantibodies were analyzed.Results:The study includes 28 patients (20 DM, 8 PM). The age of diagnosis was 43.44 ± 15.77 years, follow-up duration was 60.7 ± 70.7 months. The presenting signs and symptoms of the patients are shown in Figure 1. The parameters of disease activity before and after treatment are summarized in Table 1. The mean corticosteroid dose decreased from 31.429 ±23.934 mg to 10.278 ±12.001 (p=0.001). Other treatment methods were methotrexate (n=18), Intravenous Immunoglobulin (IVIG) (n=7), and cyclophosphamide (n=2). There were not any deaths during the follow-up. Two patients were lost to follow-up.Table 1.The Parameters of Disease Activity Before and After TreatmentBefore TreatmentAfter TreatmentP ValueCPK, mean ± std (U/L)1426 ± 2049.92263.44 ± 265.630.004LDH, mean ± std (U/L)557.5 ± 365379.78 ± 192.10.03AST, mean ± std (U/L)62.52 ± 5930.16 ± 27.590.01ALT, mean ± std (U/L)56.48 ± 49.2127.64 ± 24.520.008ESR, mean ± std (mm/hour)26.38 ± 28.9820.39 ± 18.760.36CRP, mean ± std (mg/L)19.23 ± 46.1512.53 ± 26.670.5RF, mean ± std (U/mL)0 (0)N/AN/AANA, n (%)3 (10.71)N/AN/AFigure 1.The Presenting Signs and Symptoms of the PatientsConclusion:Rituximab is shown to be effective in treating myositis along with corticosteroids as well as a corticosteroid-sparing agent in retrospective studies and open-label clinical trials; however, lack of statistical power should be underlined. Long term decrease in steroid use and decrease in disease activity markers hints the effective use of rituximab as a glucocorticoid sparing agent as well as its safety with minimal side effects.Disclosure of Interests:None declared

scholarly journals A Comparative Clinical Study of Trikarshika Kwatha with and without Lifestyle Modification in the Management of Vatarakta with Special Reference to Hyperuricaemia

2021 ◽  
pp. 10-19
Author(s):  
Md Tanzil Ansari ◽  
Sukumar Ghosh ◽  
Shailendra Kumar Singh
Keyword(s):  
Clinical Study ◽  
Lifestyle Modification ◽  
Test Results ◽  
Before And After ◽  
Comparative Clinical Study ◽  
Group A ◽  
Group B ◽  
High Level ◽  
Urate Crystals

Nowadays, people are more vulnerable to metabolic disorders due to their faulty dietary and behavioural habits. One such disorder is Vatarakta which causes functional impairment due to involvement of Sandhi (joints). It is manifested by Ruk, Toda, Sparsha asahatva, Shopha, Raga, Daha and Stabdhata in Sandhi. Vatarakta can be correlated with Hyperuricaemia or Gout due to similarity in their clinical features. Hyperuricaemia is defined as abnormally high level of uric acid in blood (i.e. >6mg/dl in female and >7mg/dl in male). On the other hand, Gout is an inflammatory response to monosodium urate crystals formed secondary to hyperuricaemia. Aims and objectives: 1. To evaluate the effectiveness of Trikarshika kwatha and lifestyle modification in the management of Vatarakta. 2. To compare the effects of Trikarshika kwatha with and without lifestyle modification in the management of Vatarakta. Materials and methods: Raw herbs of the research formulation were collected after proper identification and Kwatha was prepared for oral administration. For the clinical study, total 60 patients were selected on the basis of selection criteria. Selected patients were randomly divided into two groups. (i) Group A: 30 patients were treated with Trikarshika kwatha. (ii) Group B: 30 patients were treated with Trikarshika kwatha along with Lifestyle modification. Individual patient was treated for 45 days along with follow up at the interval of every 15 days. To assess the effectiveness of treatment, scoring pattern was followed for subjective and objective parameters. They were assessed before and after treatment. The collected data were analysed statistically by using Paired t-test. Results: On the basis of all statistical data, it can be said that patients of Group B showed better results in all parameters in comparison to patients of Group A. Conclusion: Both Trikarshika kwatha and Lifestyle modification are affective but Trikarshika kwatha with Lifestyle modification is more effective than Trikarshika kwatha without Lifestyle modification in the management of Vatarakta.

scholarly journals Does immunological remission, defined as disappearance of autoantibodies, occur with current treatment strategies? A long-term follow-up study in rheumatoid arthritis patients who achieved sustained DMARD-free status

2019 ◽  
Vol 78 (11) ◽  
pp. 1497-1504 ◽  
Author(s):  
Debbie M Boeters ◽  
Leonie E Burgers ◽  
René EM Toes ◽  
Annette van der Helm-van Mil
Keyword(s):  
Rheumatoid Arthritis ◽  
Treatment Strategies ◽  
Signs And Symptoms ◽  
Current Treatment ◽  
Dmard Therapy ◽  
Before And After ◽  
Long Term Follow Up ◽  
Free Status

ObjectivesSustained disease-modifying antirheumatic drug (DMARD)-free status, the sustained absence of synovitis after cessation of DMARD therapy, is infrequent in autoantibody-positive rheumatoid arthritis (RA), but approximates cure (ie, disappearance of signs and symptoms). It was recently suggested that immunological remission, defined as disappearance of anti-citrullinated protein antibodies (ACPA) and rheumatoid factor (RF), underlies this outcome. Therefore, this long-term observational study determined if autoantibodies disappear in RA patients who achieved sustained DMARD-free remission.MethodsWe studied 95 ACPA-positive and/or RF-positive RA patients who achieved DMARD-free remission after median 4.8 years and kept this status for the remaining follow-up (median 4.2 years). Additionally, 21 autoantibody-positive RA patients with a late flare, defined as recurrence of clinical synovitis after a DMARD-free status of ≥1 year, and 45 autoantibody-positive RA patients who were unable to stop DMARD therapy (during median 10 years) were studied. Anti-cyclic citrullinated peptide 2 (anti-CCP2) IgG, IgM and RF IgM levels were measured in 587 samples obtained at diagnosis, before and after achieving DMARD-free remission.Results13% of anti-CCP2 IgG-positive RA patients had seroreverted when achieving remission. In RA patients with a flare and persistent disease this was 8% and 6%, respectively (p=0.63). For anti-CCP2 IgM and RF IgM, similar results were observed. Evaluating the estimated slope of serially measured levels revealed that RF levels decreased more in patients with than without remission (p<0.001); the course of anti-CCP2 levels was not different (p=0.66).ConclusionsSustained DMARD-free status in autoantibody-positive RA was not paralleled by an increased frequency of reversion to autoantibody negativity. This form of immunological remission may therefore not be a treatment target in patients with classified RA.

Cardiac MRI in patients with complex CHD following primary or secondary implantation of MRI-conditional pacemaker system

2015 ◽  
Vol 26 (2) ◽  
pp. 306-314 ◽  
Author(s):  
Nadya Al-Wakeel ◽  
Darach O h-Ici ◽  
Katharina R. Schmitt ◽  
Daniel R. Messroghli ◽  
Eugénie Riesenkampff ◽  
...  
Keyword(s):  
Clinical Study ◽  
Adverse Effects ◽  
Cardiac Mri ◽  
Complete Conversion ◽  
Secondary Implantation ◽  
Before And After ◽  
Grading Scale ◽  
Clinical Questions ◽  
Mri Conditional

AbstractObjectivesIn patients with CHD, cardiac MRI is often indicated for functional and anatomical assessment. With the recent introduction of MRI-conditional pacemaker systems, cardiac MRI has become accessible for patients with pacemakers. The present clinical study aims to evaluate safety, susceptibility artefacts, and image reading of cardiac MRI in patients with CHD and MRI-conditional pacemaker systems.Material and methodsCHD patients with MRI-conditional pacemaker systems and a clinical need for cardiac MRI were examined with a 1.5-T MRI system. Lead function was tested before and after MRI. Artefacts and image readings were evaluated using a four-point grading scale.ResultsA total of nine patients with CHD (mean age 34.0 years, range 19.5–53.6 years) received a total of 11 cardiac MRI examinations. Owing to clinical indications, seven patients had previously been converted from conventional to MRI-conditional pacemaker systems. All MRI examinations were completed without adverse effects. Device testing immediately after MRI and at follow-up showed no alteration of pacemaker device and lead function. Clinical questions could be addressed and answered in all patients.ConclusionCardiac MRI can be performed safely with high certainty of diagnosis in CHD patients with MRI-conditional pacemaker systems. In case of clinically indicated lead and box changing, CHD patients with non-MRI-conditional pacemaker systems should be considered for complete conversion to MRI-conditional systems.

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