scholarly journals AN INSIGHT INTO AYURVEDIC VIEW OF SARS -COVID – 19

2020 ◽  
Vol 8 (7) ◽  
pp. 3925-3929
Author(s):  
Sreelakshmi S ◽  
Varghese Jibi ◽  
Manna Mathew ◽  
Priyanka Yadav
Keyword(s):  
Standard Treatment ◽  
Lifestyle Changes ◽  
Personal Hygiene ◽  
Treatment Modalities ◽  
Effective Management ◽  
Treatment Protocols ◽  
Health Crisis ◽  
Health Measures ◽  
Care Health ◽  
Insight Into

The Covid - 19 pandemic is defining the global health crisis of our time and occurs to be the greatest chal-lenge. The number of people getting affected and deaths are raising daily throughout the world. COVID-19 is the infectious disease caused by the most recently discovered Corona virus. The situation is much more than a health crisis with a potential to create devastating situations at social, economic, and political levels. Till date, no effective management to address this infection has been identified and attempts are being made to integrate a few traditional interventions along with standard treatment protocols of COVID-19. Ayurveda’s extensive knowledge is based on preventive care, health measures and boosting immunity. Contribution of Ayurveda in the management of various communicable and non-communicable diseases cannot be undermined. Through its wider concepts and treatment modalities, it has greater potential to ad-dress such situations. Awareness about the mode of spread of this disease is recommended highly to pre-vent oneself from falling prey to the disease. The large resource of time-tested traditional knowledge has to be used for the benefit of mankind. In addition to the personal hygiene and social distancing measures, it is of immense importance to improve individual’s natural defence system (immunity). Ayurveda can play a major role in mitigating the spread of COVID -19 by implementing some lifestyle changes along with sim-ple herbal medications and procedures by properly classifying and distinguishing the stage of the disease.

scholarly journals Interactions of COMT and ALDH2 Genetic Polymorphisms on Symptoms of Parkinson’s Disease

2021 ◽  
Vol 11 (3) ◽  
pp. 361
Author(s):  
Rwei-Ling Yu ◽  
Shao-Ching Tu ◽  
Ruey-Meei Wu ◽  
Pei-An Lu ◽  
Chun-Hsiang Tan
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Detrimental Effect ◽  
Personal Hygiene ◽  
Nucleotide Polymorphisms ◽  
Monoamine Neurotransmitters ◽  
Single Nucleotide ◽  
Detrimental Impact ◽  
Reduced Activity ◽  
Insight Into

(1) Background: Monoamine neurotransmitters play essential roles in the normal functioning of our nervous system. However, the metabolism of monoamine neurotransmitters is accompanied by the production of neurotoxic metabolites, and inefficient removal of the metabolites has been suggested to cause neurodegeneration. (2) Methods: To examine the effect of reduced activity of catechol-O-methyltransferase (COMT) and aldehyde dehydrogenase 2 (ALDH2) conferred by single nucleotide polymorphisms COMT rs4680(A) and ALDH2 rs671(A) on the symptoms of patients with Parkinson’s disease (PD), a total of 114 PD patients were recruited cross-sectionally and received genotyping for rs4680 and rs671 along with MDS-UPDRS evaluation. (3) Results: We found that patients carrying rs4680(A) had more severe bradykinesia in the upper extremity and rest tremor. Besides, patients carrying rs671(A) had more difficulty maintaining personal hygiene, while patients with genotype rs671(GG) had higher scores in the item “depressed mood.” More importantly, we found the effect of rs4680 to be moderated by rs671 SNP for the symptom of “hand movements.” The detrimental impact of rs4680(A) is more pronounced in the presence of genotype rs671(GG). (4) Conclusions: This study facilitates a deeper understanding of the detrimental effect of reduced activity of COMT and ALDH2 conferred by genetic variation and provides novel insight into the interactions between enzymes metabolizing monoamine neurotransmitters in the pathogenesis of PD.

scholarly journals Neutralizing antibodies against SARS-CoV-2: current understanding, challenge and perspective

2020 ◽  
Vol 3 (4) ◽  
pp. 285-299
Author(s):  
Yang Huang ◽  
Hui Sun ◽  
Hai Yu ◽  
Shaowei Li ◽  
Qingbing Zheng ◽  
...  
Keyword(s):  
Neutralizing Antibodies ◽  
Therapeutic Potential ◽  
Therapeutic Interventions ◽  
Viral Escape ◽  
Global Burden ◽  
Health Crisis ◽  
The Us ◽  
Preclinical And Clinical Studies ◽  
Insight Into ◽  
Rapid Emergence

Abstract The rapid emergence of Coronavirus disease-2019 (COVID-19) caused by severe acute respiratory syndrome 2 coronavirus (SARS-CoV-2) as a pandemic that presents an urgent human health crisis. Many SARS-CoV-2 neutralizing antibodies (NAbs) were developed with efficient therapeutic potential. NAbs-based therapeutics against SARS-CoV-2 are being expedited to preclinical and clinical studies with two antibody drugs, LY3819253 (LY-CoV555) and REGN-COV2 (REGN10933 and REGN10987), approved by the US Food and Drug Administration for emergency use authorization for treating COVID-19. In this review, we provide a systemic overview of SARS-CoV-2 specific or cross-reactive NAbs and discuss their structures, functions and neutralization mechanisms. We provide insight into how these NAbs specific recognize the spike protein of SARS-CoV-2 or cross-react to other CoVs. We also summarize the challenges of NAbs therapeutics such as antibody-dependent enhancement and viral escape mutations. Such evidence is urgently needed to the development of antibody therapeutic interventions that are likely required to reduce the global burden of COVID-19.

scholarly journals Individualized Hemodynamic Management in Sepsis

2021 ◽  
Vol 11 (2) ◽  
pp. 157
Author(s):  
Marcell Virág ◽  
Tamas Leiner ◽  
Mate Rottler ◽  
Klementina Ocskay ◽  
Zsolt Molnar
Keyword(s):  
Fluid Overload ◽  
Fluid Management ◽  
Multiple Organ ◽  
Treatment Protocols ◽  
Hemodynamic Management ◽  
New Approach ◽  
Hemodynamic Optimization ◽  
The Individual ◽  
Sepsis And Septic Shock ◽  
Insight Into

Hemodynamic optimization remains the cornerstone of resuscitation in the treatment of sepsis and septic shock. Delay or inadequate management will inevitably lead to hypoperfusion, tissue hypoxia or edema, and fluid overload, leading eventually to multiple organ failure, seriously affecting outcomes. According to a large international survey (FENICE study), physicians frequently use inadequate indices to guide fluid management in intensive care units. Goal-directed and “restrictive” infusion strategies have been recommended by guidelines over “liberal” approaches for several years. Unfortunately, these “fixed regimen” treatment protocols neglect the patient’s individual needs, and what is shown to be beneficial for a given population may not be so for the individual patient. However, applying multimodal, contextualized, and personalized management could potentially overcome this problem. The aim of this review was to give an insight into the pathophysiological rationale and clinical application of this relatively new approach in the hemodynamic management of septic patients.

scholarly journals Do they really wash their hands? Prevalence estimates for personal hygiene behaviour during the COVID-19 pandemic based on indirect questions

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Laura Mieth ◽  
Maike M. Mayer ◽  
Adrian Hoffmann ◽  
Axel Buchner ◽  
Raoul Bell
Keyword(s):  
Social Desirability ◽  
Online Survey ◽  
Hand Washing ◽  
Personal Hygiene ◽  
Health Crisis ◽  
Hygiene Practices ◽  
Hygiene Measures ◽  
Prevalence Estimates ◽  
Self Reports ◽  
Crosswise Model

Abstract Background During the COVID-19 pandemic, billions of people have to change their behaviours to slow down the spreading of the virus. Protective measures include self-isolation, social (physical) distancing and compliance with personal hygiene rules, particularly regular and thorough hand washing. Prevalence estimates for the compliance with the COVID-19 measures are often based on direct self-reports. However, during a health crisis there is strong public pressure to comply with health and safety regulations so that people’s responding in direct self-reports may be seriously compromised by social desirability. Methods In an online survey, an indirect questioning technique was used to test whether the prevalence of hygiene practices may be lower than in conventional surveys when confidentiality of responding is guaranteed. The Extended Crosswise Model is an indirect questioning technique that guarantees the confidentiality of responding. To the degree that direct self-reports are biased by social desirability, prevalence estimates of hygiene practices such as thorough hand washing based on the Extended Crosswise Model should be lower than those based on direct self-reports. Results We analysed data of 1434 participants. In the direct questioning group 94.5% of the participants claimed to practice proper hand hygiene; in the indirect questioning group a significantly lower estimate of only 78.1% was observed. Conclusions These results indicate that estimates of the degree of commitment to measures designed to counter the spread of the disease may be significantly inflated by social desirability in direct self-reports. Indirect questioning techniques with higher levels of confidentiality seem helpful in obtaining more realistic estimates of the degree to which people follow the recommended personal hygiene measures. More realistic estimates of compliance can help to inform and to adjust public information campaigns on COVID-19 hygiene recommendations.

Insight into the accuracy of COVID-19 beliefs predicts behavior during the pandemic

2021 ◽  
Author(s):  
Helen Fischer ◽  
Nadia Said ◽  
Markus Huff
Keyword(s):  
Public Health ◽  
Health Behaviors ◽  
National Sample ◽  
Health Measures ◽  
Insight Into

Susceptibility to COVID-19 misinformation--believing false statements to be true--negatively relates to compliance with public health measures. Here, we make the prediction that metacognitive insight into the varying accuracy of own beliefs predicts compliance with recommended health behaviors, above and beyond the accuracy of these beliefs. In a national sample of German citizens, we investigate metacognitive sensitivity, the degree to which confidence differentiates correct from incorrect beliefs. Bayesian and frequentist analyses show that citizens with higher metacognitive sensitivity were more likely to adopt recommended public health measures. Importantly, this benefit of metacognitive introspection into own beliefs held controlling for the accuracy of the beliefs. The present research highlights that insight into the varying accuracy of beliefs, rather than only the beliefs themselves, relate to citizens’ behavior during the pandemic

Efficacy of Different Treatment Modalities for Eye Cancer in Bovines

2021 ◽  
Author(s):  
M. Prasanna Lakshmi ◽  
P. Veena ◽  
R.V. Suresh Kumar ◽  
D. Rani Prameela ◽  
K. Jagan Mohan Reddy
Keyword(s):  
Squamous Cell Carcinoma ◽  
Growth Factor ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Dietary Habits ◽  
Growth Factor Receptor ◽  
Surgical Excision ◽  
Treatment Modalities ◽  
Treatment Protocols ◽  
Hereditary Factors

Background: Bovine ocular squamous cell carcinoma also called cancer eye, represents the most economically important neoplasm in large animals. Hereditary factors, environmental factors (e.g: latitude, altitude, exposure to sunlight), lack of eyelid pigmentation, age and dietary habits have all been reported to play a role in the etiopathogenesis of bovine ocular squamous cell carcinoma. In addition, in cattle the etiology has been linked to a number of viral agents, especially bovine papilloma virus and bovine herpes virus type 1 and 5. Nevertheless, ultraviolet light, viruses and circumocular pigmentation are the major epidemiologic risk factors for the development of the tumor. The efficacy of different treatment modalities for eye cancer in bovines was studied.Methods: All the animals were divided in to four groups of six animals each. Surgical excision, intra lesion BCG vaccine, surgery with auto vaccine and surgery with mitomycin was the treatment protocols followed. Immunohistochemical studies were conducted to know the rate of proliferation of bovine ye cancer. Immunopositive reaction was observed against Vascular Endothelial Growth Factor and Epidermal Growth Factor Receptor in all the cases.Result: The benefits of different treatment modalities depended on nature, type, location and extensiveness of tumor. Early detection and aggressive treatment were essential in the successful management of these tumors. A multimodal treatment approach was recommended with surgery, immunotherapy and chemotherapy in providing 100% disease free interval.

PHYSIATRY DURING COVID-19: A SURVEY BASED ANALYSIS

2021 ◽  
pp. 48-51
Author(s):  
Mrinal Joshi ◽  
Aayushi Choudhary
Keyword(s):  
Social Media ◽  
Healthy Lifestyle ◽  
Major Change ◽  
Nationwide Survey ◽  
Lifestyle Changes ◽  
Health Crisis ◽  
Rehabilitation Programs ◽  
Practice Patient ◽  
Musculoskeletal Rehabilitation

Introduction: The declaration of COVID 19 pandemic by WHO on 11th March 2020, is the dening global health crisis of the past 100 years. The following Nationwide survey was conducted to ascertain the sea changes this pandemic has brought in the physiatrist practice, patient management and preparing oneself to the challenges of rehabilitation in the POST COVID world. The survey covers the role and importance of social media in medical education and consultation in a POST COVID world. It also sheds light on the nancial implications and personal lifestyle changes that physiatrists are witnessing. A Google form comprising of 74 questions, divided in 3 se Material &Methods: ctions, was used to gather the requisite data on :- A) PRECOVID practice, management and lifestyle; B) Life during COVID pandemic; and C) Anticipated changes in POST COVID era. The survey was circulated to 400 physiatrist via various interactive groups who have been practicing either independently or in govt setups and associated hospitals nationwide. They were requested to submit their responses in a period of 30 days. In PRECOVID era an average Result: physiatrist was nely balancing his profession, personal lifestyle, learning and recreation. The LOCKDOWN clamped their practice which lead to nancial drought but hardly made a dent in productivity by engaging in webinars, reading and researching. The POST COVID time demands implementation of newer safety protocols like changes in setup, regulating the patient trafc, limiting daily procedures, engaging in distance learning through virtual conferences, maintaining a healthy lifestyle and constructing proper protocols for pulmonary, neurological and musculoskeletal rehabilitation programs for patients post recovery from COVID19, especially the patients weaning from ventilators. Conclusion: The effect of COVID19 demands major change in physiatrist professional practice like limiting consultation, following safety protocols, COVID testing, preparing consolidated program for POSTCOVID sequel. Social media is rightly poised to be a major tool for education, consultation, marketing and awareness. The role of teleconsultation needs to be reprised, recognised and regularised. Webinars and virtual conferences will nd more takers in future.

scholarly journals 1384Factors related to neck and shoulder pain during the COVID-19 pandemic in Japan

2021 ◽  
Vol 50 (Supplement_1) ◽  
Author(s):  
Sayo Tanaka ◽  
Sachiko Ohde ◽  
Kota Katanoda ◽  
Sarah Krull Abe ◽  
Takahiro Tabuchi
Keyword(s):  
Shoulder Pain ◽  
Regression Models ◽  
Cross Sectional Study ◽  
Lifestyle Changes ◽  
Internet Survey ◽  
Cross Sectional ◽  
Shoulder Stiffness ◽  
Logistic Regression Models ◽  
Health Measures ◽  
Neck And Shoulder Pain

Abstract Background Shoulder stiffness is a common health issue in Japan. During the COVID-19 pandemic, people were forced to stay home which possibly escalated the development of shoulder stiffness. We aimed to assess associations of lifestyle changes and newly developed neck and shoulder pain (NSP) during the pandemic. Methods A cross-sectional study was conducted, analyzing the data from the Japan COVID-19 and Society Internet Survey (JACSIS), an internet survey conducted from August to September 2020. Data included sociodemographic, lifestyle and health measures related to NSP during the pandemic. Multivariable logistic regression models were fitted to calculate adjusted odds ratio (AOR) with 95% confidence interval (CI) for newly developed NSP with adjustment for lifestyle, physiological and psychosocial changes. Results After exclusion of participants with existing pain, 25,482 participants (12,673 male, 12,809 female) aged 15-79 years were included in the analysis. Of these, 4.1% reported newly developed NSP. Weight gain and long sedentary time were strongly associated with the NSP (AOR (95%CI): 2.4 (2.0-2.8) and 1.81 (1.4-2.3)). Stratified analyses of 1,751 students and 4,211 teleworkers showed significant associations (AOR (95%CI): 2.1 (1.4-2.8) and 2.5 (1.9-3.2)) compared to non-workers and non-teleworkers, respectively. Conclusions Students and teleworkers became prone to NSP during the pandemic. However, factors which were associated to pain did not differ during the pandemic compared with the previous studies. Key messages Preventive measures for NSP should be taken in students and teleworkers.

scholarly journals SARS-CoV-2: An Ophthalmological Insight into the Pandemic; Challenges and Management Strategies

2021 ◽  
Vol 4 (1) ◽  
Author(s):  
Jaya Kaushik ◽  
◽  
Sandeep Shankar ◽  
Anargh V ◽  
Renu M ◽  
...  
Keyword(s):  
Key Words ◽  
Management Strategy ◽  
Management Strategies ◽  
Evidence Based ◽  
Effective Management ◽  
Protective Measures ◽  
Insight Into

Objective: To formulate a protocol for safe and effective management of an ophthalmologic practice in a hospital or a clinic during the Covid - 19 pandemic. Methods and analysis: Literature was reviewed regarding Covid-19 pandemic and ophthalmology. The following key words were used. Covid-19, telemedicine, challenges, management strategy. Result: An efficient protocol for ophthalmology practice during the Covid-19 pandemic was established which covered various protective measures that are essential and vital in the Covid-19 pandemic. Conclusion: An evidence-based protocol was formulated which may be modified in future as per the latest developments and trends in the ongoing pandemic.

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