scholarly journals MANAGEMENT OF ORAL SUBMUCOSAL FIBROSIS (OSMF) WITH PANCHGAVYA SHUKTA SHODHAN GANDUSHA AS A DINACHARYA PROCEDURE

2021 ◽  
Vol 09 (1) ◽  
pp. 91-99
Author(s):  
Jaiminikumar Shashank Rasane ◽  
Sudeep Menon ◽  
Ashutosh B Patankar
Keyword(s):  
Oral Cavity ◽  
Oral Mucosa ◽  
Burning Sensation ◽  
Treatment Modalities ◽  
Oral Submucosal Fibrosis ◽  
Submucosal Fibrosis

The rate of tobacco in addition to above conditions consumption in various forms in recent years is viewed as an emerging epidemic. The symptoms of OSMF may include burning sensation in mouth, intolerance to spicy, pain in mouth, changes in color of oral mucosa, difficulty in opening of mouth. Mukha rogas have been mentioned in Ayurved, with various treatment modalities especially Gandusha and is one of the im-portant Upakrama in Dincharya. Panchagavya is prepared by mixing five products of cow and used in tra-ditional many applications. Shukta varga includes acidic and partially alcoholic preparations of self-generated nature. Application of Panchagavya externally can reduce the Kaathinyata (Hardness) under the Twacha (skin) of oral cavity.

Burning mouth syndrome- An Oral Physicians Dilemma

2017 ◽  
Vol 6 (4) ◽  
Author(s):  
N. Kavitaa
Keyword(s):  
Oral Mucosa ◽  
Facial Pain ◽  
Clinical Signs ◽  
Burning Mouth Syndrome ◽  
Burning Sensation ◽  
Pain Disorder ◽  
Treatment Modalities ◽  
Clear Cut ◽  
Burning Mouth

Burning Mouth Syndrome (BMS) is a chronic oro-facial pain disorder that affects both genders, but predominately with higher female predilection. The condition is characterized by burning sensation present over the oral mucosa and tongue, with no definable clinical signs. The etiology for BMS is not clear cut, so does the quality of treating the condition is hampered. The present paper reviews the etiology, pathophysiology, diagnostic criteria’s and treatment modalities in treating BMS which poses as a great challenge for the oral physicians.

scholarly journals Surgical treatment of oral submucosal fibrosis

2021 ◽  
Vol 8 (11) ◽  
pp. 5583
Author(s):  
Sara Ahmed Hifny ◽  
Lujain Khalil AlShaikh ◽  
Sana Ghazai Alharthi ◽  
Renad Maher Abushanab ◽  
Noha Abduallah Aldahian ◽  
...  
Keyword(s):  
Oral Cavity ◽  
Mouth Opening ◽  
Current Evidence ◽  
Surgical Approaches ◽  
Management Approach ◽  
Surgical Interventions ◽  
Management Modality ◽  
Oral Submucosal Fibrosis ◽  
Submucosal Fibrosis

Oral submucosal fibrosis is a serious condition that might be associated with serious complications in the affected patient. The disease also represents a major challenge to the healthcare specialists and the patient before achieving proper management of the condition. Different pharmacological and surgical interventions have been validated. However, no single modality has been proved as an adequate management approach for the disease, which is probably due to the limited number of investigations in this concern and the limited knowledge about the pathogenesis of the condition. In the present literature review, we have discussed the different surgical approaches that have been reported in the literature for managing patients with oral submucosal fibrosis. These approaches mainly aimed to remove the fibrous bands in the oral cavity and maintain adequate mouth opening. It should be noted that it would be hard to write a solid conclusion in this concern because most of the current evidence was either lacking or obtained from a limited number of studies with no proper sample sizes or adequate follow up durations. Accordingly, the indication of the surgical intervention should be primarily done by the surgeon based on the degree of involvement of the oral cavity. Finally, we recommended that further comparative investigations be carried out to further demonstrate the most appropriate management modality and to rule out whether pharmacological or surgical modalities are more efficacious in these settings.

scholarly journals Egr-1 mediates low dose Arecoline induced human oral mucosa fibroblasts proliferation by transaction the expression of Wnt5a

2020 ◽  
Author(s):  
Qiang Chen ◽  
Jiuyang Jiao ◽  
Youyuan Wang ◽  
Zhihui Mai ◽  
Jing Ren ◽  
...  
Keyword(s):  
Oral Mucosa ◽  
Collagen Synthesis ◽  
Low Dose ◽  
Oral Submucous Fibrosis ◽  
High Dose ◽  
Areca Nut ◽  
Therapeutic Drugs ◽  
Submucous Fibrosis ◽  
Oral Submucosal Fibrosis ◽  
Submucosal Fibrosis

Abstract Background Arecoline is the main carcinogens in Areca nut that induce oral submucous fibrosis to develop into cancer. However, many previous studies have showed that Arecoline may inhibit proliferation and prevent collagen synthesis of fibroblasts. Results High dose Arecoline (> 32 µg/ml) could inhibit but low dose Arecoline (< 16 µg/ml) could promote the proliferation of human oral fibroblasts. Wnt5a was both sufficient and necessary for the promotion of fibrobasts proliferation. Egr-1, but not NF-κB, FOXO1, Smad2 or Smad3, mediated the expression of Wnt5a in fibrobasts. The specific siRNAs of Egr-1, Egr inhibitors or Wnt5a antibodies treatment blocked Arecoline induced Wnt5a upregulation and fibroblasts proliferation. Conclusions Egr-1 mediates low dose Arecoline induced human oral mucosa fibroblasts proliferation by transaction the expression of Wnt5a, and Egr inhibitors or Wnt5a antibodies are potential therapeutic drugs of oral submucosal fibrosis and oral cancer.

scholarly journals Egr-1 mediates low-dose arecoline induced human oral mucosa fibroblast proliferation via transactivation of Wnt5a expression

2020 ◽  
Vol 21 (1) ◽  
Author(s):  
Qiang Chen ◽  
Jiuyang Jiao ◽  
Youyuan Wang ◽  
Zhihui Mai ◽  
Jing Ren ◽  
...  
Keyword(s):  
Oral Mucosa ◽  
Low Dose ◽  
Oral Submucous Fibrosis ◽  
Subsequent Development ◽  
Fibroblast Proliferation ◽  
Antibody Treatment ◽  
Submucous Fibrosis ◽  
High Doses ◽  
Oral Submucosal Fibrosis ◽  
Submucosal Fibrosis

Abstract Background Arecoline is an alkaloid natural product found in the areca nut that can induce oral submucous fibrosis and subsequent development of cancer. However, numerous studies have shown that arecoline may inhibit fibroblast proliferation and prevent collagen synthesis. Results High doses of arecoline (> 32 μg/ml) could inhibit human oral fibroblast proliferation, while low doses of arecoline (< 16 μg/ml) could promote the proliferation of human oral fibroblasts. Wnt5a was found to be both sufficient and necessary for the promotion of fibroblast proliferation. Egr-1 could mediate the expression of Wnt5a in fibroblasts, while NF-κB, FOXO1, Smad2, and Smad3 did not. Treatment with siRNAs specific to Egr-1, Egr inhibitors, or Wnt5a antibody treatment could all inhibit arecoline-induced Wnt5a upregulation and fibroblast proliferation. Conclusions Egr-1 mediates the effect of low dose arecoline treatment on human oral mucosa fibroblast proliferation by transactivating the expression of Wnt5a. Therefore, Egr inhibitors and Wnt5a antibodies are potential therapies for treatment of oral submucosal fibrosis and oral cancer.

Ayurvedic management of Leukoplakia - A Case Study

2017 ◽  
Vol 2 (3) ◽  
Author(s):  
Makadia Krishna ◽  
Ronakgiri V. Gosai ◽  
Virpariya Jignesh ◽  
Chabhadiya Nilesh ◽  
Katrodiya Jayesh ◽  
...  
Keyword(s):  
High Risk ◽  
Oral Mucosa ◽  
Male Patient ◽  
Soft Palate ◽  
Burning Sensation ◽  
Oral Leukoplakia ◽  
Premalignant Lesion ◽  
Allopathic Medicine ◽  
Floor Of The Mouth

Oral leukoplakia (OL) is a premalignant lesion described as “a predominant white lesion of the oral mucosa which cannot be defined as any other known lesion”. OL located on the floor of the mouth, soft palate and tongue are considered as high-risk lesions, while, in other areas, they may be considered as of low malignancy risk. A Forty five years old male patient had complaints of white lesion on left lat. Surface of tongue, along with burning sensation since 4-5 months. He was diagnosed with Leukoplakia and he had taken allopathic medicine for 4 to 5 times, but it was inversely relapsed, so he was treated with Pratisarana of Bibhitaka Churna and Rasayana Churna, Yastimadhu Ghanavati as lozenges along with Rasayana tablets orally for a period of 6 months. After 6 month therapy, white lesion became disappear and no burning sensation. Thus this patient was successfully treated with above therapy with no recurrence or any complications till date.

scholarly journals CLINICAL MANIFESTATIONS OF SARCOIDOSIS ON THE PROLABIUM AND ORAL MUCOSA: MANAGEMENT

2018 ◽  
pp. 34-36
Author(s):  
P.M. Skrypnikov ◽  
T.P. Skrypnikova ◽  
Yu.M. Vitko
Keyword(s):  
Oral Cavity ◽  
Oral Mucosa ◽  
Correct Diagnosis ◽  
Clinical Signs ◽  
Clinical Manifestations ◽  
Morbidity Rate ◽  
Unknown Etiology ◽  
Toxic Substances ◽  
Male Population ◽  
Female Population

The statistics indicates on the tendency of morbidity rate of sarcoidosis to increase. The pathology affects young and older people notably. Sarcoidosis becomes a common chronic disease, which is often difficult to diagnose. Insufficient experience in recognition of this disease leads to misdiagnosis and ineffective treatment. All mentioned above highlights the extreme relevance of this issue. Sarcoidosis is a multisystem inflammatory nature disease of unknown etiology. The hereditary predisposition is taken to be but the whole family cases are also known. An abnormal immune response is also considered among the theories of the development of the disease. The infectious factor is also regarded as the cause of the disease. The increasing activity of lymphocytes, which start to produce substances promoting the formation of the granulomas, which are considered to be the basis for the pathological process, can initiate the onset of the disease. The maximum morbidity rate of sarcoidosis is observed between the ages of 35 to 55 years. Two age periods of the peak in male population are 35-40 years and about 55 years. The rate of sarcoidosis morbidity among female population is 65%. Up to 700 new cases of sarcoidosis are registered in Ukraine annually. The clinical signs of sarcoidosis vary. This pathology is more often manifested by the bilateral lymphadenopathy of lung roots, eyes and skin lesions. The liver, spleen, lymph nodes, heart, nervous system, muscles, bones and other organs can also be affected. In dental practice sarcoidosis can be manifested on the prolabium, oral mucosa and salivary glands. Blood laboratory indices (the increased level of calcium) are changed in sarcoidosis. Chest X-ray, MRI and CT also demonstrate changes in the lungs. The test for detection of granulomas shows positive Kveim reaction (the formation of purple-red nodules due to administration of antigen). Biopsy and bronchoscopy facilitate detection of both direct and indirect signs of sarcoidosis of the lungs. A general treatment of sarcoidosis is provided by a pulmonologist, who can assess the severity of the lesion and provide appropriate treatment. The core of treatment is based on corticosteroids. In severe cases immunosuppressors, anti-inflammatory drugs, antioxidants are prescribed. A dentist performs oral cavity sanation, professional hygiene. Mouth rinses with Dekasan solution, sublingual Lisobakt pills are prescribed to prevent inflammatory lesions. Patients with sarcoidosis are recommended to avoid solar radiation and contact with chemical and toxic substances harmful to the liver, reduction of the consumption of foods rich in calcium. Healthy life-style is crucial in prevention of exacerbations of sarcoidosis. In the remission period regular medical check-ups and oral cavity sanation are recommended. The correct diagnosis in rare diseases requires highly qualified dental professionals, the interdisciplinary approach in the diagnosing and management of patients with this pathology.

scholarly journals Symptoms of Oral Submucosal Fibrosis: Our Experience with Intralesional Injection Treatment

2011 ◽  
Vol 2 (1) ◽  
pp. 45-48 ◽  
Author(s):  
PV Dhond ◽  
Rajesh Yadav ◽  
Mudit Mittal ◽  
Shashi Kant
Keyword(s):  
Indian Population ◽  
Cost Effective ◽  
Injection Technique ◽  
Intralesional Injection ◽  
Clinical Settings ◽  
Care Hospital ◽  
Primary Care Hospital ◽  
Intralesional Injections ◽  
Oral Submucosal Fibrosis ◽  
Submucosal Fibrosis

ABSTRACT Objective This study evaluates the symptoms and effects of peroral intralesional injections in relieving the symptoms of oral submucosal fibrosis (OSMF) in our clinical settings. Study design Retrospective clinical review at a primary care hospital of 32 patients with extensive OSMF who underwent peroral intralesional injections of steroid, hyaluronidase, placentrex and lignocaine performed in office setting. Results The main symptoms were change in color of buccal mucosa, trismus, burning mouth, vesicles in oral cavity. All patients experienced considerable improvement in their symptoms over a duration of 2 to 6 weeks. Conclusions Though, a large number of Indian population is suffering and seeking treatment for OSMF, unfortunately not much has been done in this area. It is difficult to find studies on peroral intralesional injection technique. When there is lack of reliable evidence of oral submucosal fibrosis treatment, the old technique of peroral intralesion shots of steroid, hyaluronidase, placentrex in lignocaine is safe and effective in resolving the symptoms associated with OSMF. The therapy is very cost effective and also reduces the need of surgery.

scholarly journals DIAGNOSIS OF ORAL MUCOSAL PATHOLOGY IN PATIENTS WITH VARIOUS MANIFESTATIONS OF GROUP B VITAMIN IMBALANCE

2021 ◽  
Vol 16 (4) ◽  
pp. 77-83
Author(s):  
Anna Yatsenko ◽  
Lidiya Trankovskaya ◽  
Olga Artyulova
Keyword(s):  
Oral Cavity ◽  
Oral Mucosa ◽  
Human Body ◽  
Clinical Symptoms ◽  
Negative Impact ◽  
Vitamin B12 Deficiency ◽  
Vitamin Deficiency ◽  
The Body ◽  
B Vitamins ◽  
Group B

Subject. The scientific works of recent years show an increase in the degree of negative impact of vitamin deficiency and vitamin-like substances on the state of health of the population. With the deficiency of most vitamins, synthetic processes and regeneration of oral tissues are reduced, so often the initial signs of hypovitaminosis are stomatitis, gingivitis, glossitis, and therefore, it is dentists who are the first to diagnose deviations in the body associated with vitamin deficiency. This justifies the relevance and practical value of studying and describing clinical cases of manifestations of deficient vitamin conditions in the oral cavity. The object – is to study the effect of B vitamins on the oral mucosa in order to increase the effectiveness of diagnosis of vitamin-deficient conditions of the human body. Methodology. These clinical examples illustrate the management experience of patients with manifestations of deficient vitamin conditions on the oral mucosa. Clinical and laboratory methods of diagnosing the analysed conditions of the organism were applied. Statistical processing of materials was carried out using the STATISTICA 10 software (StatSoft, Inc., USA). Results. The deficient condition of the organism in relation to vitamins B2, B6, B12 in patients 18-75 years old has been studied. Characteristic clinical changes on the oral mucosa of the examined patients were established. So, in most patients with vitamin B2 deficiency, the classic Sebrel triad was found: dermatitis, glossitis, cheilitis. In those examined with a lack of vitamin B6, language desquamations (smoothed, polished language) were determined in the 83.6%, often combined with glossodinia. Patients with vitamin B12 deficiency were characterized by a lesion in the form of Meller-Gunter glossitis in 74.9% of cases, moreover, 67.6% of patients showed paresthesia in the area of tongue and oral mucosa. Conclusions. The study found that the first clinical symptoms of deficient conditions of the presented vitamins of group B were found from the oral cavity. Thus, it is the dentist who is the first to diagnose the pathological states of lack of group B vitamins in the human body, which emphasizes the importance and relevance of continuing to study these states of the body.

scholarly journals A. Sugar, J. Banozzi, I. Rat, K. Shallai. Diseases of the oral cavity. Budapest, 1980, 383 pages

1981 ◽  
Vol 62 (5) ◽  
pp. 84-85
Author(s):  
F. G. Gasimov ◽  
V. Y. Khitrov ◽  
K. A. Khamidullina
Keyword(s):  
Immune System ◽  
Oral Cavity ◽  
Oral Mucosa ◽  
Medical Specialty ◽  
Historical Background ◽  
Modern Knowledge

The monograph begins with an interesting historical background on the origin and formation of the medical specialty in periodontal and oral mucosa diseases. Chapter 1 "Biology of the oral cavity" is presented taking into account modern knowledge of embryology, anatomy, histology and physiology. Most of it is occupied by the characteristics of the immune system of the oral cavity, based on the latest data from immunology. The authors present the oral cavity as a well-coordinated, harmoniously functioning system.

scholarly journals PREVENTION OF CANDIDIASIS IN PATIENTS USING REMOVABLE DENTURES

2022 ◽  
Author(s):  
Andrey SEVBITOV ◽  
◽  
Aleksey DOROFEEV ◽  
Sergey MIRONOV ◽  
Samer AL-KHOURY ◽  
...  
Keyword(s):  
Oral Cavity ◽  
Oral Mucosa ◽  
Oral Candidiasis ◽  
Age Groups ◽  
Local Immunity ◽  
Thermal Insulating ◽  
Removable Plate ◽  
Orthopedic Care ◽  
Oral Tissue ◽  
Receptor Apparatus

Despite innovations in orthopedic dentistry, removable dentures belong to the most popular orthopedic care category. Removable dentures are combined stimuli that affect the mucous membrane and neuro-receptor apparatus. Acrylic plastic prostheses, widely used in prosthetic dentistry, have a negative side mechanical, chemical-toxic, sensitizing, and thermal insulating effect on oral tissue and prosthetic impression area. This is often complicated by a violation of the biocenosis of the oral cavity, the growth of pathogenic microflora that releases toxins, especially an increase in the number of yeast colonies that irritate the oral mucosa and prosthetic stomatitis. It was observed 100 patients with oral candidiasis of various age groups from 45 to 65 years. Of these, 60 patients with removable plate prostheses; 40 patients with partially removable prostheses. Chronic forms of candidiasis were diagnosed in 40 patients and with exacerbation of chronic forms of candidiasis in 60 people. The number of untreated carious cavities and poor hygienic condition of the oral cavity directly affects the severity of candidiasis. Acute forms of candidiasis were observed mainly in patients with high DMF and PMA indices. The severity of candidiasis depends on the degree and duration of wearing dentures and hygienic conditions - the most severe forms of invasive candidiasis were observed in the presence of removable plate prostheses, the complete absence of teeth, and the use of a prosthesis for more than 10-15 years. A combined lesion of the oral mucosa and the red border of the lips was observed mainly in patients older than 60 years. The presence of candidiasis in the oral cavity in patients with removable plate prostheses leads to a statistically significant change in the indicators of local immunity of the oral cavity: an increase in the concentration of serum IgG and IgA and the values of the coefficient of the balance of local immunity factors.

Sign in / Sign up

Export Citation Format

Share Document