scholarly journals Assessment of Chemical Properties of Tinospora Cordifolia

2020 ◽  
Vol 6 (12) ◽  
pp. 45-49
Author(s):  
Nafeesa Begum and Ranjith Y
Keyword(s):  
Urinary Tract ◽  
Chemical Analysis ◽  
Medicinal Plant ◽  
Urinary Tract Infections ◽  
Skin Diseases ◽  
Chemical Properties ◽  
Tinospora Cordifolia ◽  
Anti Inflammatory ◽  
Tract Infections ◽  
Important Medicinal Plant

The plant produces have phyto medicine this can be derived from bark, leaf, flower, fruit and seeds (Raghunathan and Rama Mitra, 1982). In the present study the phyto chemical analysis were carried out in leaf and bark of Tinosporacordifolia. Tinosporacordifolia is an important medicinal plant used in ayurvedic system of medicine. The stem of the plant is grayish brown in colour and bitter in taste. The stem is soft wooded, dry. The plant has been used as an anti spasmodic, anti inflammatory, Jaundice, Diabetes, seminal weakness, urinary tract infections, fever, skin diseases and expectorant, carminative, digestive, anti stress and aphrodisiac.

scholarly journals Chemical profiling and antioxidant activity of Equisetum ramosissimum Desf. stem extract, a potential traditional medicinal plant for urinary tract infections

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Jeyalatchagan Sureshkumar ◽  
Singamoorthy Amalraj ◽  
Ramar Murugan ◽  
Anantharaj Tamilselvan ◽  
Jayaraj Krupa ◽  
...  
Keyword(s):  
Antioxidant Activity ◽  
Urinary Tract ◽  
Medicinal Plant ◽  
Petroleum Ether ◽  
Urinary Tract Infections ◽  
Pathogenic Bacteria ◽  
Methanolic Extract ◽  
Chemical Profiling ◽  
Stem Extract ◽  
Tract Infections

Abstract Background Equisetum ramosissimum Desf. (E. ramosissimum) is a widely used traditional medicinal plant to treat urinary tract infections (UTIs) by ethnic people throughout the world. The utility of the plant in treating urinary-related disorders was evaluated against selected pathogenic bacteria which has major role in causing UTIs. Hence, the present study executed to extract phytochemicals like total phenolics and flavonoids, chemical profiling by GC–MS analysis and to test their antioxidant activity from stem extracts of E. ramosissimum. The extraction process was directed by petroleum ether, chloroform, ethyl acetate, methanol, and aqueous solvents. Results The GC–MS analysis yielded 24 phytoconstituents with linoleic acid, palmitic acid, nonacosane, hexahydrofarnesyl acetone, and octacosane as major compounds. Methanolic extract yielded maximum amount of phenolics (TPC) and flavonoids (TFC) with 600.02 ± 0.22 mg GAE/g and 631.38 ± 0.69 mg QE/g, respectively. Methanolic extract also exhibited notable free radical scavenging activity with an IC50 of 123.89 ± 0.73, 150.10 ± 1.02, 146.01 ± 0.54, and 63.73 ± 6.12 µg/mL for DPPH, FRAP, ABTS, and O2− assays, respectively. The minimum inhibitory concentration (MIC) required to inhibit the growth of tested pathogenic bacteria was observed in aqueous and methanolic extracts with the value being 31.25 µg/mL against R. equi and V. cholerae. As like, methanolic and petroleum ether extracts efficiently inhibited the growth of B. subtilis with the MIC of 31.25 µg/mL. Conclusion It was concluded that the notable effect of methanolic and aqueous extracts against the uropathogenic bacteria reported in this study supported the traditional uses of this plant in treating UTIs. The results acquired from this investigation revealed that E. ramosissimum stem extract might be considered as an interesting candidate in the development of antibacterial agent against UTIs coupled with antioxidant properties.

scholarly journals Multi-Faceted Roles of Giloy: A Mini-Review

2021 ◽  
Vol 5 (1) ◽  
pp. 1-5
Author(s):  
Ghosh S
Keyword(s):  
Immune System ◽  
Urinary Tract ◽  
Urinary Tract Infections ◽  
Liver Diseases ◽  
The Body ◽  
Tinospora Cordifolia ◽  
Nutritional Content ◽  
Highly Effective ◽  
Tract Infections

In Ayurveda, Giloy is considered one of the best medicines to treat various fevers and other conditions. Giloy is one of the three Amrit plants. Amrit means the ‘root of immortality’. Hence, it is also called Amritavalli or Amrita in Sanskrit. Giloy is scientifically known as Tinospora cordifolia or Guduchi in Hindi. The stem of Giloy is considered highly effective because of its high nutritional content and the alkaloids found in it but the root and leaves also can be used. This herb activates the immune system of our body and increase vitality in a person. Inclusion of Giloy juice or kadha in diet twice a day can improve immunity. It is full of antioxidants and helps to release toxins from the body. Giloy juice also detoxifies skin and improves skin nourishment. Giloy is also used for liver diseases, urinary tract infections, and heart-related issues. Thus, Giloy can improve immunity and many other metabolisms in our body. However, more in depth researches are arrested to throw some light in immune enhancing activity of this herb.

scholarly journals Is Non-Steroidal Anti-Inflammatory Therapy Non-Inferior to Antibiotic Therapy in Uncomplicated Urinary Tract Infections: a Systematic Review

2020 ◽  
Vol 35 (6) ◽  
pp. 1821-1829 ◽  
Author(s):  
Matthew R. Carey ◽  
Valerie M. Vaughn ◽  
Jason Mann ◽  
Whitney Townsend ◽  
Vineet Chopra ◽  
...  
Keyword(s):  
Systematic Review ◽  
Urinary Tract ◽  
Antibiotic Therapy ◽  
Urinary Tract Infections ◽  
Anti Inflammatory ◽  
Tract Infections

scholarly journals Retrospective Evaluation of the Performance of Leukocyte Parameter of the Automated Urine Analyzer and Its Concordance with Urine Culture

2021 ◽  
Author(s):  
Murat Koser ◽  
Nilgün Işıksaçan ◽  
Ramazan Korkusuz ◽  
Gülçin Şahingöz Erdal ◽  
Pınar Atar ◽  
...  
Keyword(s):  
Urinary Tract ◽  
Chemical Analysis ◽  
Urinary Tract Infections ◽  
Urine Culture ◽  
Urine Samples ◽  
Analytical Sensitivity ◽  
Predictive Values ◽  
Leukocyte Counts ◽  
Tract Infections ◽  
Sensitivity Specificity

Objective: Complete urinalysis (CUA) is one of the indispensable screening tests of clinical laboratories. The compatibility of this test with urine culture is of indispensable importance in the diagnosis and treatment of urinary tract infections. We aimed to evaluate the suitability of the leukocyte parameter measured in the microscopic units of the fully automated urine analyzers which replace traditional methods, by grouping them according to the results of chemical analysis. Materials and Methods: Leukocyte counts in the reported CUA results of 4685 outpatients and the results of 113 urine cultures studied on the same day were analyzed. Noncentrifugated urine samples were included in the analysis. Cells were digitally imaged by flow microscopy. Chemical analyzes were performed using dual wavelength reflectance method. Urine samples were evaluated after 24 hours of incubation. Results: High power field (HPF) values were recorded by grouping the leukocyte counts as negative, trace, 1+, 2+ and 3+. The arithmetic means of HPF values of the groups were calculated as 1.2, 2.1, 5.0, 11 and 208 white blood cell (WBCs/HPF). Bacterial growth was detected in 19 of 113 patients and no reproduction was observed in the remaining 94 cases. When results of microscopic examinations and chemical analysis were compared with the culture results, the analytical sensitivity, specificity, positive, and negative predictive values for microscopic urinalysis were 25%, 86%, 61.3%, and 58.3%, respectively. While, the analytical sensitivity, specificity, positive, and negative predictive values for chemical analysis of urine were 25.8%, 87.7%, 69.7%, and 51.4%, respectively. Conclusion: The workload of medical laboratories is increasing, and the use of urine autoanalyzers may be preferred for busy laboratories. In the diagnosis and follow-up of urinary tract infections, complete urinalysis by autoanalysers in which the harmony of their microscopy and chemical units are closely monitored, may reduce the need for unnecessary requests for urine culture, but it cannot replace urine culture.

scholarly journals Non-steroidal anti-inflammatory drugs for treating symptomatic uncomplicated urinary tract infections in non-pregnant adult women

2021 ◽  
Vol 2021 (11) ◽  
Author(s):  
Ashwin Sachdeva ◽  
Arjun Nambiar ◽  
Bhavan Prasad Rai ◽  
Rajan Veeratterapillay ◽  
Christopher Harding
Keyword(s):  
Urinary Tract ◽  
Urinary Tract Infections ◽  
Adult Women ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Tract Infections

scholarly journals Cytokines and SLPI profiles in children and adults with urinary tract infections

2019 ◽  
pp. 13-19
Author(s):  
M. Kolesnуk ◽  
V. Driianska ◽  
N. Stepanova ◽  
O. Lavrenchuk ◽  
I. Bagdasarova ◽  
...  
Keyword(s):  
Urinary Tract ◽  
Inflammatory Cytokines ◽  
Urinary Tract Infections ◽  
Prognostic Markers ◽  
Kidney Injury ◽  
Serum Levels ◽  
Lipocalin 2 ◽  
Tnf Α ◽  
Anti Inflammatory ◽  
Tract Infections

Pro- and anti-inflammatory cytokines, SLPI and NGAL are involved in anti-infectious immunity. Studies of these indicators’ role in patients with urinary tract infections (UTIs) may determine their significance as diagnostic and prognostic markers in the case of pyelonephritis and cystitis. The objective of our study was to investigate plasma and urine cytokines and SLPI levels in patients with UTIs, determine the features in children and adults. Materials and methods. ELISA method and related test systems - «Immunotech», «Diaclon» (France); «DRG» (Germany), «Hycult biotechnology» ((Netherlands)  were used to study blood cytokine levels in 118 adults and 67 children, SLPI levels in the blood and urine in 59 and 58, respectively. NGAL serum levels of 26 adults with acute pyelonephritis (AP) and 30 adults with chronic pyelonephritis (ChP) were studied using «Human lipocalin-2 / NGAL ELIZA» (Biovendor, Czech Republik) for NGAL. Comparison groups included 10 healthy donors and 11 patients with acute kidney injury (AKI).  Results. The study showed an increase in pro- (IL-1, -17, -18, -23, TNF-α, MCP-1) and anti-inflammatory cytokines (IL-17, TGF-β), SLPI, NGAL in patients with UTI, some features in the case of chronic cystitis (ChC), AP and ChP. In adults, TNF-α in the blood and urine, IL-17 in the blood was higher in the case of ChC than ChP. The analysis showed a significant increase in all studied indicators’ levels for AP and ChP in children and adults. The average MCP-1 level in patients with AP was significantly higher than ChP, whereas TNF-α did not differ. In adults, IL-18 and IL-23 were highest in the case of AP, and TGF-β was the highest in the case of ChP. MCP-1, IL-23 levels in the blood of adults were higher than in children in the case of AP, and TNF-α - in the case of ChP. SLPI is involved in the AP pathogenesis and ChP exacerbation. High SLPI levels have been determined in serum and urine (NGAL in the blood) in patients with pyelonephritis (NGAL - AP) who can be used, as well as cytokines, as additional diagnostic and prognostic markers. Conclusions. High levels of TNF-α, MCP-1, and IL-23 in the blood of adults and children confirm their important role in both AP and ChP, but MCP-1 can be considered as an AP predictor/ ChP exacerbation. According to the studied cytokines, adults have a more significant immune response. The SLPI level is an additional feature for diagnosing and monitoring the course of pyelonephritis and cystitis.

scholarly journals Treatment of urinary tract infections with medicinal plants: Monographs of some plants species revealed by traditherapists

2020 ◽  
Vol 1 (1) ◽  
Author(s):  
Victorien Dougnon ◽  
Phénix Assogba ◽  
Hornel Koudokpon ◽  
Césaire Ayena ◽  
Sosthéne Vissoh ◽  
...  
Keyword(s):  
Urinary Tract ◽  
Medicinal Plants ◽  
Urinary Tract Infections ◽  
Viral Infections ◽  
Skin Diseases ◽  
Scientific Evidence ◽  
Traditional Use ◽  
Suitable Alternative ◽  
The World ◽  
Tract Infections

Medicinal plants are a precious heritage for humanity and especially for the majority of poor communities in developing countries who depend on them for primary health care and livelihoods. They are used in traditional practices against urinary tract infections without any scientific evidence for most of the species used. This work aims to have a summary of the literature on some medicinal plants used in the treatment of urinary tract infections. To do this, this study was carried out based on the different medicinal plants cited by herbalists in southern Togo against urinary tract infections. The names of these different plants have each been the subject of research with keywords in search engines such as Google Scholar, PubMed, FreefullPdf, and others to bring out the traditional use of these plants in the world. From all of the above, it appears that the medicinal plant species cited by actors of the Togolese pharmacopoeia are used to treat several diseases in the world. The organs of these plants, such as leaves, bark, and roots are used in the treatment of common illnesses such as typhoid fever, diarrhea, malaria, bronchitis, and hypofertility. Coughs, colds, skin diseases, toothache, gonorrhoea, viral infections, and many other diseases are treated with these plants. The plants are often combined with other plants in traditional medicine. They are used in the form of decoction, fumigation, herbal tea, and others. The type of disease treated by the plants changes from region to region and is also dependent on the culture of the region in the world. The use of medicinal plants is a very ancient practice. It is a very suitable alternative to modern medicine. However, there is a need to have more detailed studies on these plants, such as their toxicological effects.

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