scholarly journals Prevalence of Non-Responsiveness to an Indigenous Recombinant Hepatitis B Vaccine: A Study among Health Care Workers in A Tertiary Hospital

2020 ◽  
Vol 6 (6) ◽  
pp. 1-5
Author(s):  
J Gunasekaran ◽  
P Neelu Sree
Keyword(s):  
Health Care ◽  
Hepatitis B ◽  
Health Care Workers ◽  
Tertiary Hospital ◽  
Hbv Infection ◽  
Hla Typing ◽  
Hepatitis B Vaccination ◽  
Hbv Vaccine ◽  
South Indian ◽  
Care Workers

Background and Aim: Health care workers (HCW) are at higher risk of contracting HBV infection. Non-response to HBV vaccine is one of the major impediments to prevent healthcare associated HBV infection (HAHI). We estimated the prevalence of non-responsiveness to initial 3-dose regimen of an indigenous recombinant HBV vaccine (GeneVac-B) among South Indian HCWs and typed the HLA in non-responders. Study Design and Method: Of the 778 subjects screened over 1 year, 454 completed all three doses of the hepatitis B vaccination. Anti-HBs titers were estimated by microparticle enzyme immunoassay Automated ELISA. HLA typing was done using AllSet+™ Gold SSP. Conclusion: Our findings suggest that non-response to HBV vaccine is not a major impediment to prevent HAHI. Robust seroprotection rates can be achieved using this indigenous HBV vaccine. However, gender and BMI might influence the level of anti-HBs titers. We recommend the use of this cost effective HBV vaccine as well as post vaccination anti-HBs testing to prevent HAHI among HCWs.

scholarly journals STATUS OF HEPATITIS B VACCINATION AMONG HEALTH CARE WORKERS IN A RURAL TERTIARY HOSPITAL

2013 ◽  
Vol 2 (39) ◽  
pp. 7564-7567
Author(s):  
Umesh Kawalkar ◽  
Prashant Dahire ◽  
Vandana Kakrani ◽  
Priti Kogade ◽  
Vinod Vedpathak ◽  
...  
Keyword(s):  
Health Care ◽  
Hepatitis B ◽  
Health Care Workers ◽  
Tertiary Hospital ◽  
Hepatitis B Vaccination ◽  
Care Workers

Risk of Exposure, Perception and Vaccination Status of Chronic Viral Hepatitis among Health Care Workers in Benue State, North Central Nigeria

2021 ◽  
Vol 2 (1) ◽  
pp. 57-62
Author(s):  
A S Obekpa ◽  
A O Malu ◽  
R Bello ◽  
M Duguru
Keyword(s):  
Health Care ◽  
Hepatitis B ◽  
Viral Hepatitis ◽  
Health Care Workers ◽  
Hepatitis B Vaccine ◽  
Hepatitis B Vaccination ◽  
Care Workers ◽  
Risk Of Exposure ◽  
Needle Prick ◽  
Needle Prick Injury

Health care workers are high-risk group for contracting hepatitis B and C virus infections. Hepatitis B and C can be contracted in the hospital setting by needle prick injury, contact with blood (and body fluids) and during invasive medical procedures. This study aims to assess the risk of exposure, the concern or perception of healthcare workers about getting infected (with HBV and/or HCV) from the workplace and the level of HBV vaccination uptake among them. The study was carried out during a capacity building workshop organized for health care workers from all the Local Government Areas in Benue State. A self-administered questionnaire was distributed to 168 participants in attendance, after obtaining verbal consent. One hundred and thirty-eight (138) questionnaires were properly filled and returned, 115 (83.3%) have had needle prick injury, 127 (92%) have had blood spilling on them and 118 (85.5%) have been involved in the management of hepatitis patients. One hundred and nineteen (86.2%) were afraid of contracting hepatitis infection from their place of work, 133 (96.4%) were aware of hepatitis B vaccine for adult, 87 (63%) had received at least one dose of hepatitis B vaccine but only 56 (40.6%) received the complete three doses. Health care workers in Benue State are aware of the risk of contracting viral hepatitis at their workplace and are concerned about this risk. However, the uptake of hepatitis B vaccination among them remains poor.

Hepatitis B vaccination status and associated factors among health care workers in Burkina Faso

2013 ◽  
Vol 23 (1) ◽  
pp. 72-77 ◽  
Author(s):  
H.G. Ouédraogo ◽  
S. Kouanda ◽  
S. Tiendrébeogo ◽  
G.A. Konseimbo ◽  
C.E. Yetta ◽  
...  
Keyword(s):  
Health Care ◽  
Hepatitis B ◽  
Burkina Faso ◽  
Health Care Workers ◽  
Associated Factors ◽  
Vaccination Status ◽  
Hepatitis B Vaccination ◽  
Care Workers

Management of Health Care Workers Remotely Vaccinated for Hepatitis B Who Sustain Significant Blood and Body Fluid Exposures

1988 ◽  
Vol 9 (10) ◽  
pp. 462-464 ◽  
Author(s):  
Michael B. Snyder
Keyword(s):  
Health Care ◽  
Hepatitis B ◽  
Mucous Membrane ◽  
Health Care Workers ◽  
Body Fluid ◽  
Hepatitis B Vaccination ◽  
Recombinant Hepatitis ◽  
Care Workers ◽  
Hepatitis B Vaccines ◽  
Duration Of Protection

The availability of both plasma-derived and recombinant hepatitis B vaccines has given hospitals and other health care institutions the possibility of significantly reducing a major infectious hazard in the workplace. With the increasing use and acceptance of these vaccines, many employees who have a significant blood or body fluid exposure (percutaneous or mucous membrane) have already completed hepatitis B vaccination. Concerns have arisen over the duration of protection of vaccination, as it has been over five years since the introduction of the plasma-derived vaccine.

scholarly journals Hepatitis B virus genotype E infection among Egyptian health care workers

2017 ◽  
Vol 5 (2) ◽  
pp. 100-105 ◽  
Author(s):  
Reem Elmaghloub ◽  
Ashraf Elbahrawy ◽  
Gamal El Didamony ◽  
Ahmed Elwassief ◽  
Abdel-Gawad Saied Mohammad ◽  
...  
Keyword(s):  
Health Care ◽  
Hepatitis B ◽  
Health Care Providers ◽  
Health Care Workers ◽  
Hbv Infection ◽  
Care Work ◽  
Care Providers ◽  
Health Care Work ◽  
Care Workers ◽  
The Mean

AbstractBackground and ObjectivesHealth Care Workers (HCWs) are at a high risk of needle stick injuries and HBV infection in Egypt; this problem is further aggravated by low Hepatitis B (HB) vaccination coverage. Limited data are available on the prevalence of HBV infection in Egyptian HCWs. In this study, we aimed to assess the HBV infection rate and genotypes among Egyptian HCWs.MethodsFive hundred and sixty-four (564) HCWs were included. Of them, 258 (45.74%) were health care providers and 306 (54.25%) were non-health care providers. All HCWs completed both the study questionnaires and provided a blood sample for HBV testing. Indeed, all HCWs were tested for Hepatitis B surface antigen (HBsAg) and antibody to Hepatitis B core antigen (anti-HBc), by enzyme-linked immunosorbent assay. HBVDNA was checked for HCWs who tested positive for HBsAg and/or anti-HBc, by nested Polymerase Chain Reaction (PCR). HBVDNA positive HCWs were further subjected to HBV genotyping.ResultsThe mean age of included HCWs was 33.0 ± 9.8 years, of whom 319 (56.56%) were males. The mean duration of health care work was 9.3 ± 6.7 years. The frequency of HBsAg and anti-HBc were 1.4%, and 24.5%, respectively. Old age and prolonged duration of health care work were significantly associated with anti-HBc seropositivity. Among 140 HCWs positive for HBsAg and/or anti-HBc, 14 (10 %) had positive HBVDNA by PCR. HBV/E (n= 7), HBV/D (n= 3) and co-infection with E and D (n= 4) genotypes were detected.ConclusionEgyptian HCWs have a significantly high rate of HBV exposure. The detection of HBV/E genotype among Egyptian HCWs suggests prevalent transmission of HBV/E among Egyptian populations.

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