scholarly journals Linking gut microbiome to bone mineral density: a shotgun metagenomic dataset from 361 elderly women

Gigabyte ◽  
2021 ◽  
Vol 2021 ◽  
pp. 1-7
Author(s):  
Qi Wang ◽  
Qiang Sun ◽  
Xiaoping Li ◽  
Zhefeng Wang ◽  
Haotian Zheng ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Bone Mass ◽  
Mass Loss ◽  
Bone Mineral ◽  
Gut Microbiome ◽  
Elderly Women ◽  
The Elderly ◽  
Sequencing Data ◽  
Mineral Density ◽  
Bone Mass Loss

Bone mass loss contributes to the risk of bone fracture in the elderly. Many factors including age, obesity, estrogen and diet, are associated with bone mass loss. Mice studies suggested that the gut microbiome might affect the bone mass by regulating the immune system. However, there has been little evidence from human studies. Bone loss increases after menopause. Therefore, we have recruited 361 Chinese post-menopausal women to collect their fecal samples and metadata to conduct a metagenome-wide association study (MWAS) to investigate the influence of the gut microbiome on bone health. Gut microbiome sequencing data were produced using the BGISEQ-500 sequencer. Bone mineral density (BMD) was calculated using a Hologic dual energy X-ray machine, and body mass index (BMI) and age were also recorded. This collected data allows exploration of the gut microbial diversity and their links to bone mass loss as well as to microbial markers for bone mineral density. In addition, these data are potentially useful in studying the role that the gut microbiota might play in bone mass loss and in exploring the process of bone mass loss.

scholarly journals Shotgun Metagenomics of 361 elderly women reveals gut microbiome change in bone mass loss

2019 ◽  
Author(s):  
Qi Wang ◽  
Qiang Sun ◽  
Xiaoping Li ◽  
Zhefeng Wang ◽  
Haotian Zheng ◽  
...  
Keyword(s):  
Bone Mass ◽  
Mass Loss ◽  
Gut Microbiome ◽  
Elderly Women ◽  
The Elderly ◽  
Intestinal Microbiome ◽  
Mineral Density ◽  
Shotgun Metagenomics ◽  
Bone Mass Loss ◽  
Microbiome Data

AbstractBone mass loss contributes to the risk of bone fracture in the elderly. Many factors including age, obesity, estrogen and diet, are associated with bone mass loss. Mice studies suggest that the intestinal microbiome might influence the bone mass by regulating the immune system, however there has been little evidence from human studies.We have recruited 361 Chinese elderly women to collect data for a metagenomic-wide association study (MWAS) to investigate the influence of the gut microbiome on bone health. Gut microbiome data were produced using BGISEQ500 sequencing, BMD was calculated using Hologic dual energy X-ray machine, BMI (Body Mass Index) and age were also provided. This therefore data allows exploration of gut microbiome diversity and links to bone mass loss, as well as microbial species and modules as markers for bone mineral density. Making these data potentially useful in studying the role the gut microbiota might play in bone mass loss and offering exploration into the bone mass loss process.

Bone mass in totally thyroidectomized patients. Role of calcitonin deficiency and exogenous thyroid treatment

1991 ◽  
Vol 124 (5) ◽  
pp. 521-525 ◽  
Author(s):  
Diana C. Gonzalez ◽  
Carlos A. Mautalen ◽  
Pedro H. Correa ◽  
Elias El Tamer ◽  
Sara El Tamer
Keyword(s):  
Bone Mineral Density ◽  
Lumbar Spine ◽  
Bone Mass ◽  
Bone Mineral ◽  
Statistical Significance ◽  
Premenopausal Women ◽  
Mineral Density ◽  
Bone Mass Loss ◽  
Parathyroid Function ◽  
The Difference

Abstract. Calcitonin has an uncertain role in the preservation of bone mass. Since surgical thyroidectomy abolishes the calcitonin secretion in response to calcium, the bone mineral density at the radius shaft and lumbar spine was measured in 60 patients (5 men, 16 premenopausal, 34 postmenopausal euparathyroid and 5 postmenopausal hypoparathyroid women) who had undergone near total thyroidectomy for thyroid cancer 8.4±0.7 years before the study. All patients were maintained on suppressive doses of thyroid hormones. Bone mineral density values of the radius shaft (expressed as Z-score) of 34 postmenopausal euparathyroid women was significantly below the normal average (mean ± sem = −0.59 ±0.2; p=0.01). Bone mineral density of the lumbar spine was also below the normal average although the difference only approached statistical significance (−0.36±0.2; 0.05 <p<0.1). The bone mineral density of neither the radius nor the spine differed from normal levels in the premenopausal women and the postmenopausal hypoparathyroid women. Unexpectedly, the bone mineral density of the spine was significantly increased in the 5 thyroidectomized men. The results indicate that thyroidectomized women have a diminished bone mass after the menopause only if parathyroid function is normal. Since the patients were receiving thyroid hormone at suppressive doses, the present study is not able to separate the relative contributions of calcitonin deficit and exogenous thyroid on bone mass loss.

scholarly journals Plenary Lecture: Strategies for skeletal health in the elderly

2002 ◽  
Vol 61 (2) ◽  
pp. 173-180 ◽  
Author(s):  
Richard Eastell ◽  
Helen Lambert
Keyword(s):  
Bone Mineral Density ◽  
Vitamin D ◽  
Bone Mass ◽  
Bone Mineral ◽  
Peak Bone Mass ◽  
The Elderly ◽  
Mineral Density ◽  
Skeletal Health ◽  
Nutritional Factors ◽  
Age Related

Osteoporosis is a common disease in the elderly, and the fractures that result from this disorder affect 40 % of women and 14 % of men over the age of 50 years. The risk of fracture relates to bone mineral density and the risk of falling, among other factors. Low bone mineral density in the elderly can result from either low peak bone mass or accelerated bone loss, or a combination of the two. Nutritional factors play a role in both the attainment of peak bone mass and in the rate of age-related bone loss. The main determinants of peak bone mass are genetic factors, early-life nutrition, diet and exercise. Of the nutritional factors Ca, and particularly milk, are the most important contributors to peak bone mass. Some of these factors may interact; for example, a low dietary Ca in addition to an unfavourable vitamin D receptor gene polymorphism may result in low peak bone mass. The age-related changes in bone mass may also have a genetic basis, but deficiency of oestrogen is a major contributor. In addition, undernutrition is common in the elderly, and lack of dietary protein contributes both to impaired bone mineral conservation and increased propensity to fall. There is a decreased ability of the intestine to adapt to a low-Ca diet with increasing age. Other dietary factors include vitamin K, Zn and fruit and vegetables. Adequate nutritional status, particularly of Ca and vitamin D, is essential for the successful pharmaceutical treatment of osteoporosis. Thus, strategies for enhancing skeletal health in the elderly must begin in early childhood, and continue throughout life.

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