Upregulation of long noncoding RNA growth arrest-specific 5 mediates pro-inflammatory mechanisms of diabetic wound healing impairment

2021 ◽  
Vol 1 (1) ◽  
Keyword(s):  
Wound Healing ◽  
Long Noncoding Rna ◽  
Noncoding Rna ◽  
Growth Arrest ◽  
Diabetic Wound ◽  
Diabetic Wound Healing ◽  
Healing Impairment

Long Noncoding RNA LINC01435 Impedes Diabetic Wound Healing by Facilitating YY1-Mediated HDAC8 Expression

2021 ◽  
Author(s):  
Wan Fu ◽  
Diefei Liang ◽  
Xiaoying Wu ◽  
Hongxing Chen ◽  
Xiaosi Hong ◽  
...  
Keyword(s):  
Wound Healing ◽  
Long Noncoding Rna ◽  
Noncoding Rna ◽  
Diabetic Wound ◽  
Diabetic Wound Healing

scholarly journals Novel Long Noncoding RNA lnc-URIDS Delays Diabetic Wound Healing by Targeting Plod1

Diabetes ◽  
2020 ◽  
Vol 69 (10) ◽  
pp. 2144-2156
Author(s):  
Mengdie Hu ◽  
Yuxi Wu ◽  
Chuan Yang ◽  
Xiaoyi Wang ◽  
Wei Wang ◽  
...  
Keyword(s):  
Wound Healing ◽  
Long Noncoding Rna ◽  
Noncoding Rna ◽  
Diabetic Wound ◽  
Diabetic Wound Healing

scholarly journals Long Noncoding RNA GAS5 Regulates Macrophage Polarization and Diabetic Wound Healing

2020 ◽  
Vol 140 (8) ◽  
pp. 1629-1638 ◽  
Author(s):  
Junyi Hu ◽  
Liping Zhang ◽  
Cole Liechty ◽  
Carlos Zgheib ◽  
Maggie M. Hodges ◽  
...  
Keyword(s):  
Wound Healing ◽  
Long Noncoding Rna ◽  
Noncoding Rna ◽  
Macrophage Polarization ◽  
Diabetic Wound ◽  
Diabetic Wound Healing

Application of Basic Fibroblast Growth Factor May Reverse Diabetic Wound Healing Impairment

1993 ◽  
Vol 31 (4) ◽  
pp. 331-334 ◽  
Author(s):  
Linda G. Phillips ◽  
Kay M. Abdullah ◽  
Peter D. Geldner ◽  
Stewart Dobbins ◽  
Francis Ko ◽  
...  
Keyword(s):  
Wound Healing ◽  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Basic Fibroblast Growth Factor ◽  
Fibroblast Growth ◽  
Diabetic Wound ◽  
Diabetic Wound Healing ◽  
Healing Impairment

The Role Of MicroRNA In The Diabetic Wound Healing Impairment

2011 ◽  
Vol 165 (2) ◽  
pp. 230-231
Author(s):  
J. Xu ◽  
W. Wu ◽  
L. Zhang ◽  
W. Dorsett-Martin ◽  
M.E. Mitchell ◽  
...  
Keyword(s):  
Wound Healing ◽  
Diabetic Wound ◽  
Diabetic Wound Healing ◽  
Healing Impairment

scholarly journals TET2-interacting long noncoding RNA promotes active DNA demethylation of the MMP-9 promoter in diabetic wound healing

2019 ◽  
Vol 10 (11) ◽  
Author(s):  
Liyan Zhou ◽  
Meng Ren ◽  
Tingting Zeng ◽  
Wei Wang ◽  
Xiaoyi Wang ◽  
...  
Keyword(s):  
Wound Healing ◽  
Long Noncoding Rna ◽  
Noncoding Rna ◽  
Excision Repair ◽  
Skin Wound ◽  
Dna Demethylation ◽  
Skin Wound Healing ◽  
Active Dna Demethylation ◽  
Diabetic Wound Healing ◽  
Base Excision

Abstract Wound healing in diabetic skin is impaired by excessive activation of matrix metalloproteinase-9 (MMP-9). MMP-9 transcription is activated by Ten-eleven translocation 2 (TET2), a well-known DNA demethylation protein that induces MMP-9 promoter demethylation in diabetic skin tissues. However, how TET2 is targeted to specific loci in the MMP-9 promoter is unknown. Here, we identified a TET2-interacting long noncoding RNA (TETILA) that is upregulated in human diabetic skin tissues. TETILA regulates TET2 subcellular localization and enzymatic activity, indirectly activating MMP-9 promoter demethylation. TETILA also recruits thymine-DNA glycosylase (TDG), which simultaneously interacts with TET2, for base excision repair-mediated MMP-9 promoter demethylation. Together, our results suggest that the TETILA serves as a genomic homing signal for TET2-mediated demethylation specific loci in MMP-9 promoter, thereby disrupting the process of diabetic skin wound healing.

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