The Role Of IL-16 as a lymphocyte attractant appears to be conserved through phylogeny: preliminary evidence that recombinant human IL-16 preferentially attracts regulatory lymphocytes in the amphibian, Xenopus laevis

2021 ◽  
Vol 1 (2) ◽  
Keyword(s):  
Xenopus Laevis ◽  
Preliminary Evidence ◽  
Regulatory Lymphocytes

Engagement and Outcomes Associated with Contextual Annotation Features of a Digital Health Solution

2020 ◽  
pp. 193229682097640
Author(s):  
Michelle Dugas ◽  
Weiguang Wang ◽  
Kenyon Crowley ◽  
Anand K. Iyer ◽  
Malinda Peeples ◽  
...  
Keyword(s):  
Digital Health ◽  
Data Entry ◽  
Secondary Data ◽  
Well Being ◽  
Preliminary Evidence ◽  
Future Research ◽  
Note Taking ◽  
Potential Benefits

Background: Digital health solutions targeting diabetes self-care are popular and promising, but important questions remain about how these tools can most effectively help patients. Consistent with evidence of the salutary effects of note-taking in education, features that enable annotation of structured data entry might enhance the meaningfulness of the interaction, thereby promoting persistent use and benefits of a digital health solution. Method: To examine the potential benefits of note-taking, we explored how patients with type 2 diabetes used annotation features of a digital health solution and assessed the relationship between annotation and persistence in engagement as well as improvements in glycated hemoglobin (A1C). Secondary data from 3142 users of the BlueStar digital health solution collected between December 2013 and June 2017 were analyzed, with a subgroup of 372 reporting A1C lab values. Results: About a third of patients recorded annotations while using the platform. Annotation themes largely reflected self-management behaviors (diet, physical activity, medication adherence) and well-being (mood, health status). Early use of contextual annotations was associated with greater engagement over time and with greater improvements in A1C. Conclusions: Our research provides preliminary evidence of the benefits of annotation features in a digital health solution. Future research is needed to assess the causal impact of note-taking and the moderating role of thematic content reflected in notes.

Adaptive and maladaptive perfectionism in depression: Preliminary evidence on the role of adaptive and maladaptive rumination

2012 ◽  
Vol 53 (6) ◽  
pp. 774-778 ◽  
Author(s):  
Raffaella Di Schiena ◽  
Olivier Luminet ◽  
Pierre Philippot ◽  
Céline Douilliez
Keyword(s):  
Preliminary Evidence ◽  
Maladaptive Perfectionism

scholarly journals Associations between neurochemical receptor genes, 2D:4D, impulsivity and relationship quality

2018 ◽  
Vol 14 (12) ◽  
pp. 20180642 ◽  
Author(s):  
Eiluned Pearce ◽  
Rafael Wlodarski ◽  
Anna Machin ◽  
Robin I. M. Dunbar
Keyword(s):  
Relationship Quality ◽  
Multiple Testing ◽  
Romantic Relationship ◽  
Preliminary Evidence ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide ◽  
Digit Ratios ◽  
The Relationship ◽  
Romantic Relationship Quality

The ratio between the second and fourth digits (2D:4D) has been widely used as a proxy for fetal exposure to androgens and has been linked to a number of sociosexual traits in humans. However, the role of genes in this equation remains unknown. Here ( N = 474), we test, firstly, for associations between 2D:4D and single-nucleotide polymorphisms (SNPs) in nine neurochemical receptor genes ( AR, OXTR, AVPR1A, OPRM1, DRD1/2, ANKK1, 5HTR1A/2A ), and secondly, whether digit ratios mediate the relationship between genetic variation and sociosexuality. We demonstrate significant associations between AR , OPRM1 and AVPR1A and 2D:4D. Moreover, mediation analysis indicates that, in women, AR and OPRM1 variation drives digit ratios, which are related positively to impulsivity and, for OPRM1 , negatively to romantic relationship quality. Although these findings are subject to multiple testing issues, this study provides preliminary evidence that in women genetic factors may affect both impulsivity and perceived relationship quality through influencing factors indexed by digit ratios.

2,4-D Butoxyethyl Ester Kinetics in Embryos of Xenopus laevis: The Role of the Embryonic Jelly Coat in Reducing Chemical Absorption

2006 ◽  
Vol 52 (1) ◽  
pp. 113-120 ◽  
Author(s):  
Andrea N. Edginton ◽  
Claude Rouleau ◽  
Gerald R. Stephenson ◽  
Herman J. Boermans
Keyword(s):  
Xenopus Laevis ◽  
Chemical Absorption ◽  
Jelly Coat

scholarly journals Susceptible supply limits the role of climate in the COVID-19 pandemic

2020 ◽  
Author(s):  
Rachel E. Baker ◽  
Wenchang Yang ◽  
Gabriel A. Vecchi ◽  
C. Jessica E. Metcalf ◽  
Bryan T. Grenfell
Keyword(s):  
Epidemic Model ◽  
Preliminary Evidence ◽  
Control Measures ◽  
Effective Control ◽  
High Susceptibility ◽  
Emerging Pathogen ◽  
Geographic Variations ◽  
Summer Temperatures ◽  
Endemic Infections

AbstractPreliminary evidence suggests that climate may modulate the transmission of SARS-CoV-2. Yet it remains unclear whether seasonal and geographic variations in climate can substantially alter the pandemic trajectory, given high susceptibility is a core driver. Here, we use a climate-dependent epidemic model to simulate the SARS-CoV-2 pandemic probing different scenarios of climate-dependence based on known coronavirus biology. We find that while variations in humidity may be important for endemic infections, during the pandemic stage of an emerging pathogen such as SARS-CoV-2 climate may drive only modest changes to pandemic size and duration. Our results suggest that, in the absence of effective control measures, significant cases in the coming months are likely to occur in more humid (warmer) climates, irrespective of the climate-dependence of transmission and that summer temperatures will not substantially limit pandemic growth.

scholarly journals Imaging patterns of calcium transients during neural induction in Xenopus laevis embryos

2000 ◽  
Vol 113 (19) ◽  
pp. 3519-3529 ◽  
Author(s):  
C. Leclerc ◽  
S.E. Webb ◽  
C. Daguzan ◽  
M. Moreau ◽  
A.L. Miller
Keyword(s):  
Xenopus Laevis ◽  
Calcium Signalling ◽  
Neural Induction ◽  
Calcium Transients ◽  
Free Calcium ◽  
Treated Animal ◽  
Cell Stage ◽  
Subsequent Formation ◽  
Xenopus Laevis Embryos

Through the injection of f-aequorin (a calcium-sensitive bioluminescent reporter) into the dorsal micromeres of 8-cell stage Xenopus laevis embryos, and the use of a Photon Imaging Microscope, distinct patterns of calcium signalling were visualised during the gastrulation period. We present results to show that localised domains of elevated calcium were observed exclusively in the anterior dorsal part of the ectoderm, and that these transients increased in number and amplitude between stages 9 to 11, just prior to the onset of neural induction. During this time, however, no increase in cytosolic free calcium was observed in the ventral ectoderm, mesoderm or endoderm. The origin and role of these dorsal calcium-signalling patterns were also investigated. Calcium transients require the presence of functional L-type voltage-sensitive calcium channels. Inhibition of channel activation from stages 8 to 14 with the specific antagonist R(+)BayK 8644 led to a complete inhibition of the calcium transients during gastrulation and resulted in severe defects in the subsequent formation of the anterior nervous system. BayK treatment also led to a reduction in the expression of Zic3 and geminin in whole embryos, and of NCAM in noggin-treated animal caps. The possible role of calcium transients in regulating developmental gene expression is discussed.

scholarly journals Role of zinc in the control of oocyte maturation in Xenopus laevis

2000 ◽  
Vol 21 (3) ◽  
pp. 165-168 ◽  
Author(s):  
KEN-ICHI WATANABE ◽  
TOSHINOBU TOKUMOTO ◽  
KATSUTOSHI ISHIKAWA
Keyword(s):  
Xenopus Laevis ◽  
Oocyte Maturation

Firms' death rate and spatial agglomeration. Evidence on the resilience of italian local Production systems

2012 ◽  
pp. 101-126
Author(s):  
Giulio Cainelli ◽  
Sandro Montresor ◽  
Marzetti Giuseppe Vittucci
Keyword(s):  
Production Systems ◽  
Local Level ◽  
Preliminary Evidence ◽  
Industrial Clusters ◽  
Industrial Districts ◽  
Spatial Agglomeration ◽  
Start Up ◽  
Urbanization Economies ◽  
Italian Provinces

The paper investigates the role spatial agglomeration has in affecting firm mortality of industries. In particular, the role of variety and specialization is addressed, along with the extent to which industrial clusters can be retained industrial districts. Empirical evidence is provided for a large panel of Italian provinces and manufacturing sectors, over the period 1995-2007. Urbanization economies, rather than localization ones, significantly diminish firm mortality of industries at the local level. The same holds true for industrial variety, even far from the specialization core. Industrial districts, instead, are neither safe nor dangerous places for firms, unless variety is controlled for. Preliminary evidence is also provided by the serial and spatial autocorrelation of firm' death and start-up rates.

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