scholarly journals New Insights on Cu Homeostasis in Vine Plants Through the Use of Cu Isotopes

2020 ◽  
Author(s):  
Simon Blotevogel ◽  
Priscia Oliva ◽  
Laurence Denaix ◽  
Jérôme Viers ◽  
Stéphane Audry ◽  
...  
Keyword(s):  
Cu Isotopes ◽  
Cu Homeostasis

scholarly journals Cosmogenic effects on Cu isotopes in IVB iron meteorites

2016 ◽  
Vol 182 ◽  
pp. 145-154 ◽  
Author(s):  
Heng Chen ◽  
Frédéric Moynier ◽  
Munir Humayun ◽  
M. Cole Bishop ◽  
Jeffrey T. Williams
Keyword(s):  
Iron Meteorites ◽  
Cu Isotopes

Investigations of Pb and Cu Isotopes to Trace Contamination Sources from the Artificial Shihwa Lake in Korea

2020 ◽  
Vol 95 (sp1) ◽  
pp. 1122
Author(s):  
Hyeryeong Jeong ◽  
Jin Young Choi ◽  
Jihyun Lee ◽  
Kongtae Ra
Keyword(s):  
Contamination Sources ◽  
Cu Isotopes

scholarly journals Adaptive responses in men fed low- and high-copper diets

2003 ◽  
Vol 90 (1) ◽  
pp. 161-168 ◽  
Author(s):  
Linda J. Harvey ◽  
Gosia Majsak-Newman ◽  
Jack R. Dainty ◽  
D. John Lewis ◽  
Nicola J. Langford ◽  
...  
Keyword(s):  
Stable Isotope ◽  
Dietary Intervention ◽  
Limited Information ◽  
Adaptive Responses ◽  
Stable Isotope Label ◽  
Isotope Label ◽  
Adult Men ◽  
True Absorption ◽  
Wide Range ◽  
Cu Homeostasis

The study of Cu metabolism is hampered by a lack of sensitive and specific biomarkers of status and suitable isotopic labels, but limited information suggests that Cu homeostasis is maintained through changes in absorption and endogenous loss. The aim of the present study was to employ stable-isotope techniques to measure Cu absorption and endogenous losses in adult men adapted to low, moderate and high Cu-supplemented diets. Twelve healthy men, aged 20–59 years, were given diets containing 0·7, 1·6 and 6·0 mg Cu/d for 8 weeks, with at least 4 weeks intervening washout periods. After 6 weeks adaptation, apparent and true absorption of Cu were determined by measuring luminal loss and endogenous excretion of Cu following oral administration of 3 mg highly enriched65Cu stable-isotope label. Apparent and true absorption (41 and 48% respectively) on the low-Cu diet were not significantly different from the high-Cu diet (45 and 48% respectively). Endogenous losses were significantly reduced on the low- (0·45mg/d;P<0·001) and medium- (0·81 mg/d;P=0·001) compared with the high-Cu diet (2·46mg/d). No biochemical changes resulting from the dietary intervention were observed. Cu homeostasis was maintained over a wide range of intake and more rapidly at the lower intake, mainly through changes in endogenous excretion.

scholarly journals Copper Transport and Disease: What Can We Learn from Organoids?

2019 ◽  
Vol 39 (1) ◽  
pp. 75-94 ◽  
Author(s):  
Hannah Pierson ◽  
Haojun Yang ◽  
Svetlana Lutsenko
Keyword(s):  
Three Dimensional ◽  
Transport Processes ◽  
Intestinal Epithelial ◽  
Metabolic Coupling ◽  
Significant Research ◽  
Cu Homeostasis ◽  
Vitro Model ◽  
Cu Uptake ◽  
Fat Processing

Many metals have biological functions and play important roles in human health. Copper (Cu) is an essential metal that supports normal cellular physiology. Significant research efforts have focused on identifying the molecules and pathways involved in dietary Cu uptake in the digestive tract. The lack of an adequate in vitro model for assessing Cu transport processes in the gut has led to contradictory data and gaps in our understanding of the mechanisms involved in dietary Cu acquisition. The recent development of organoid technology has provided a tractable model system for assessing the detailed mechanistic processes involved in Cu utilization and transport in the context of nutrition. Enteroid (intestinal epithelial organoid)-based studies have identified new links between intestinal Cu metabolism and dietary fat processing. Evidence for a metabolic coupling between the dietary uptake of Cu and uptake of fat (which were previously thought to be independent) is a new and exciting finding that highlights the utility of these three-dimensional primary culture systems. This review has three goals: ( a) to critically discuss the roles of key Cu transport enzymes in dietary Cu uptake; ( b) to assess the use, utility, and limitations of organoid technology in research into nutritional Cu transport and Cu-based diseases; and ( c) to highlight emerging connections between nutritional Cu homeostasis and fat metabolism.

scholarly journals Masses of neutron-rich Ni and Cu isotopes and the shell closure at Z = 28 , N = 40

2007 ◽  
Vol 34 (1) ◽  
pp. 5-9 ◽  
Author(s):  
S. Rahaman ◽  
J. Hakala ◽  
V. -V. Elomaa ◽  
T. Eronen ◽  
U. Hager ◽  
...  
Keyword(s):  
Shell Closure ◽  
Cu Isotopes

scholarly journals Conserved Cu-MicroRNAs in Arabidopsis thaliana Function in Copper Economy under Deficiency

Plants ◽  
2019 ◽  
Vol 8 (6) ◽  
pp. 141 ◽  
Author(s):  
Muhammad Shahbaz ◽  
Marinus Pilon
Keyword(s):  
Arabidopsis Thaliana ◽  
Small Rnas ◽  
Wild Type ◽  
Microrna Target ◽  
Electron Carrier ◽  
Cu Deficiency ◽  
Regulatory Circuits ◽  
Transgenic Lines ◽  
Cu Homeostasis

Copper (Cu) is a micronutrient for plants. Three small RNAs, which are up-regulated by Cu deficiency and target transcripts for Cu proteins, are among the most conserved microRNAs in plants. It was hypothesized that these Cu-microRNAs help save Cu for the most essential Cu-proteins under deficiency. Testing this hypothesis has been a challenge due to the redundancy of the Cu microRNAs and the properties of the regulatory circuits that control Cu homeostasis. In order to investigate the role of Cu-microRNAs in Cu homeostasis during vegetative growth, we used a tandem target mimicry strategy to simultaneously inhibit the function of three conserved Cu-microRNAs in Arabidopsis thaliana. When compared to wild-type, transgenic lines that express the tandem target mimicry construct showed reduced Cu-microRNA accumulation and increased accumulation of transcripts that encode Cu proteins. As a result, these mimicry lines showed impaired photosynthesis and growth compared to wild type on low Cu, which could be ascribed to a defect in accumulation of plastocyanin, a Cu-containing photosynthetic electron carrier, which is itself not a Cu-microRNA target. These data provide experimental support for a Cu economy model where the Cu-microRNAs together function to allow maturation of essential Cu proteins under impending deficiency.

scholarly journals Initial Cu enrichment in sources of giant porphyry deposits revealed by Cu isotopes

2019 ◽  
Vol 93 (S1) ◽  
pp. 255-256
Author(s):  
Yuan‐chuan Zheng ◽  
Chang‐da Wu ◽  
Sheng‐Ao Liu ◽  
Zhen‐qing Li ◽  
Bo Xu ◽  
...  
Keyword(s):  
Porphyry Deposits ◽  
Cu Isotopes

scholarly journals β decay of Ni75 and the systematics of the low-lying level structure of neutron-rich odd- A Cu isotopes

2020 ◽  
Vol 102 (3) ◽  
Author(s):  
F. L. Bello Garrote ◽  
E. Sahin ◽  
Y. Tsunoda ◽  
T. Otsuka ◽  
A. Görgen ◽  
...  
Keyword(s):  
Level Structure ◽  
Β Decay ◽  
Cu Isotopes

scholarly journals Lifetime Measurements in Neutron-rich Cu Isotopes

2013 ◽  
Vol 44 (3) ◽  
pp. 505 ◽  
Author(s):  
M. Doncel ◽  
E. Sahin ◽  
A. Gadea ◽  
G. [Angelis]de Angelis ◽  
B. Quintana ◽  
...  
Keyword(s):  
Lifetime Measurements ◽  
Cu Isotopes
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