scholarly journals Hypoadrenocorticism in dogs – the Mad Hatter of veterinary internal medicine

2020 ◽  
Vol 51 (3) ◽  
pp. 281-292
Author(s):  
Magdalena Palić ◽  
Vesna Matijatko ◽  
Filip Kajin ◽  
Iva Šmit ◽  
Marin Torti ◽  
...  
Keyword(s):  
Internal Medicine ◽  
Veterinary Medicine ◽  
Laboratory Data ◽  
Hypovolemic Shock ◽  
Gastrointestinal Symptoms ◽  
Addison’S Disease ◽  
Addison's Disease ◽  
Adequate Treatment ◽  
Duration Of Symptoms ◽  
Internal Medicine Faculty

Hypoadrenocorticism arises from insufficient adrenal gland function and is also known as Addison’s disease, a rarely occurring disease (0.1%) in dogs. Due to its oscillatory course and overall nonspecific symptoms, it is a diagnostic challenge for clinicians, and is often misdiagnosed or unattended among other differentials. There are two forms of hypoadrenocorticism: primary and secondary. The aim of this study was to analyse the data of dogs suffering from Addison’s disease, treated at the Clinic for Internal Medicine, Faculty of Veterinary Medicine, University of Zagreb, Croatia and to compare them with data from similar institutions worldwide. The archive of Clinic for Internal Medicine, Faculty of Veterinary Medicine, Zagreb, Croatia was searched to investigate and statistically analyse signalment, clinical and laboratory data, and the duration of symptoms, treatment protocols and outcome of canine hypoadrenocorticism. The study group included 14 dogs (36% male and 64% female) diagnosed with hypoadrenocorticism. All dogs had a history of gastrointestinal symptoms, i.e. vomiting in 100%, diarrhoea in 64% and melena in 7%. Hypovolemic shock was noted in 57%, hypothermia in 64% and bradycardia in 29% of cases. The most frequently observed laboratory abnormalities were an increase in BUN (86%), creatinine (57%) and potassium concentration (79%), and a decrease in sodium (71%), Na/K ratio (86%), cholesterol (21%) and glucose concentration (21%). Duration of symptoms (till ACTH stimulation test performance) was broad, from 2 – 2190 days (median 90±1195.5 days). The outcome was favourable in 100% cases after initiation of adequate treatment.

Adrenocortical Crisis Triggered by Levothyroxine in an Unrecognized Autoimmune Polyglandular Syndrome Type-2: A Case Report with Review of the Literature.

2020 ◽  
Vol 15 ◽  
Author(s):  
Dhruvkumar M. Patel ◽  
Jayanti K. Gurumikhani ◽  
Mukund Kumar Patel ◽  
Maitri M. Patel ◽  
Suyog Y Patel ◽  
...  
Keyword(s):  
Case Report ◽  
Case Reports ◽  
Neuropsychiatric Symptoms ◽  
Hypovolemic Shock ◽  
Addison’S Disease ◽  
Addison's Disease ◽  
Thyroid Function Tests ◽  
Thyroid Disorder ◽  
Review Of The Literature ◽  
Autoimmune Hypothyroidism

Background: Autoimmune polyglandular syndrometype-2 (APS-2) is an uncommon endocrine disorder of Addison's disease with an autoimmune thyroid disorder and/or type 1 diabetes mellitus. The diagnosis is more challenging when a patient presents with nonspecific neuropsychiatric features with hypothyroidism in the setting of unrecognized Addison's disease. Case report: We report a case of subclinical autoimmune hypothyroidism presented with nonspecific neuropsychiatric symptoms precipitated by stress. Despite levothyroxine treatment, her symptoms deteriorated and she was admitted with persistent vomiting and hypovolemic shock. Clinical features and laboratory parameters were suggestive of underlying adrenocortical insufficiency. Pre-existing autoimmune hypothyroidism combined with Addison's disease confirmed the diagnosis of unrecognized APS-2. She remarkably improved and her thyroid function tests also normalized with the treatment of corticosteroids only. Review of the literature: We identified only five published case reports of our title by searching the database. Neufeld and Betterle have reported their data of APS-2 and concluded that a full-blown clinical picture of two or more components of the syndrome is like the tip of the iceberg. Conclusion : The patients of one major component of APS-2 should be screened for other components of the disease to pick up latent cases. Addison's disease should be ruled out in patients of hypothyroidism who are intolerant to levothyroxine.

scholarly journals Unmasking of Addison’s disease in COVID-19

2021 ◽  
Vol 9 ◽  
pp. 2050313X2110277
Author(s):  
Pallav Bhattarai ◽  
Holley Allen ◽  
Abhimanyu Aggarwal ◽  
Daniel Madden ◽  
Kristen Dalton
Keyword(s):  
Infectious Disease ◽  
Case Report ◽  
Mental Status ◽  
Cerebral Edema ◽  
Gastrointestinal Symptoms ◽  
Addison’S Disease ◽  
Altered Mental Status ◽  
Initial Presentation ◽  
Addison's Disease

This case report highlights the initial presentation of Addison’s disease in a 19-year-old individual with coronavirus disease. Coronavirus disease is an infectious disease, which often presents with fever and respiratory and gastrointestinal symptoms. Here, we describe a challenging case of a patient with coronavirus disease, who initially presented with altered mental status, hyponatremia, and cerebral edema, with subsequent workup leading to the diagnosis of Addison’s disease.

scholarly journals Efficacy of Albendazole Against Strongylus sp. and Hematology Changes on Equine in Yogyakarta Special Region

2021 ◽  
Vol 39 (2) ◽  
pp. 130
Author(s):  
Yuriadi Yuriadi ◽  
Ida Tjahajati ◽  
Guntari Titik Mulyani ◽  
Kelviano Muqit ◽  
Aidah Rahmanita
Keyword(s):  
Internal Medicine ◽  
Veterinary Medicine ◽  
Gastrointestinal Diseases ◽  
Routine Examination ◽  
Horse Population ◽  
Male And Female ◽  
Significant Difference ◽  
Before And After ◽  
Internal Medicine Faculty ◽  
Special Region

The infestation of Strongylus sp. in horses can cause losses to horse breeders, including anorexia, anemia, gastrointestinal diseases and can cause death and decrease the horse population in DIY. Albendazole was a Benzimidazole preparation that is often used to treat worms in ruminants. This study also aims to determine the effect of Albendazole on blood images before and after treatment. The material used in this study were 10 horses with male and female sex,  over 3 years old, and infected with Strongylus sp. with an infestation rate of 200 EPG in faeces. Before treatment of drug was carried out, the faeces was examined with Mc Master method. After treatment with Albendazole, the worm eggs were examined three times at intervals of three days. Routine examination of worm eggs and blood was carried out at the Laboratory of the Department of Internal Medicine, Faculty of Veterinary Medicine, Universitas Gadjah Mada. The results showed that the EPG number decreased from the 0th, 3rd, 6th and 9th day of examinations. The average number of EPG on the 0th day was 990 eggs/gram, and the examination on the 9th day showed the number of eggs was 0 eggs/gram. The results of the hematology examination also showed no significant difference except for the high number of eosinophils on the 12th day after drug administration. The conclusion from this research is that Albendazole as a worm medicine can kill Srongylus sp. however, it does not affect the horse's hematology and health status.

Addison's disease as a rare cause of chronically elevated transaminases

2004 ◽  
Vol 42 (05) ◽  
Author(s):  
GC Gurakuqi ◽  
V Stadlbauer ◽  
H Warnkross ◽  
M Trauner
Keyword(s):  
Addison’S Disease ◽  
Addison's Disease ◽  
Elevated Transaminases

"STEROID-CELL" ANTIBODY IN ENDOCRINE DISEASES

1974 ◽  
Vol 76 (4) ◽  
pp. 729-740 ◽  
Author(s):  
Peter Kamp ◽  
Per Platz ◽  
Jørn Nerup
Keyword(s):  
Leydig Cells ◽  
Addison’S Disease ◽  
Addison's Disease ◽  
Hormone Production ◽  
Cortical Cells ◽  
Endocrine Diseases ◽  
Cell Antibody ◽  
Indirect Immunofluorescence Technique ◽  
Males And Females ◽  
Adrenal Cortical Cells

ABSTRACT By means of an indirect immunofluorescence technique, sera from 116 patients with Addison's disease, an equal number of age and sex matched controls and 97 patients with other endocrine diseases were examined for the occurrence of antibody to steroid-producing cells in ovary, testis and adrenal cortex. Fluorescent staining was observed in the theca cells of growing follicles, the theca lutein cells, testicular Leydig cells and adrenal cortical cells, i. e. cells which contain enzyme systems used in steroid hormone production. The "steroid-cell" antibody was present in 24 % of the patients with idiopathic Addison's disease, equally frequent in males and females, and in 17 % of the patients with tuberculous Addison's disease, but was rarely found in controls, including patients with other endocrine diseases. Female hypergonadotrophic hypogonadism made an exception, since the "steroid-cell" antibody was found in about half the cases with this condition.

P450 side-chain cleavage enzyme autoantibodies in canine Addison's disease

2013 ◽  
pp. 1-1
Author(s):  
Alisdair Boag ◽  
Kerry McLaughlin ◽  
Mike Christie ◽  
Peter Graham ◽  
Harriet Syme ◽  
...  
Keyword(s):  
Addison’S Disease ◽  
Side Chain ◽  
Addison's Disease ◽  
Side Chain Cleavage ◽  
Chain Cleavage ◽  
Cleavage Enzyme

A case of addison's disease associated with ankylosing spondylitis

2014 ◽  
Author(s):  
Neslihan Soysal Atile ◽  
Sibel Guldiken ◽  
Fatih Saritas ◽  
Huseyin Celik ◽  
Armagan Tugrul
Keyword(s):  
Ankylosing Spondylitis ◽  
Addison’S Disease ◽  
Addison's Disease
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