Surveillance Progress for Crucial Vector-Borne Parasitic Diseases in China

Fan Yang;  ; Zhengbin Zhou; Yuan Fang; Xinyu Feng; Qin Chen; Pin Yang; Jing Xu; Shizhu Li

doi:10.46234/ccdcw2020.177

Promising Role of Wolbachia as Anti-parasitic Drug Target and Eco-Friendly Biocontrol Agent

Recent Patents on Anti-Infective Drug Discovery ◽

10.2174/1574891x14666190211162403 ◽

2019 ◽

Vol 14 (1) ◽

pp. 69-79 ◽

Cited By ~ 1

Author(s):

Tooran Nayeri Chegeni ◽

Mahdi Fakhar

Keyword(s):

Drug Target ◽

Biocontrol Agent ◽

Pathogen Transmission ◽

Parasitic Diseases ◽

Pests And Diseases ◽

Filarial Nematodes ◽

Reproductive Incompatibility ◽

Vector Borne ◽

Potential Strategy

Background: Wolbachia is the most common endosymbiotic bacteria in insectborne parasites and it is the most common reproductive parasite in the world. Wolbachia has been found worldwide in numerous arthropod and parasite species, including insects, terrestrial isopods, spiders, mites and filarial nematodes. There is a complicated relationship between Wolbachia and its hosts and in some cases, they create a mutual relationship instead of a parasitic relationship. Some species are not able to reproduce in the absence of infection with Wolbachia. Thus, the use of existing strains of Wolbachia bacteria offers a potential strategy for the control of the population of mosquitoes and other pests and diseases. Methods: We searched ten databases and reviewed published papers regarding the role of Wolbachia as a promising drug target and emerging biological control agents of parasitic diseases between 1996 and 2017 (22 years) were considered eligible. Also, in the current study several patents (WO008652), (US7723062), and (US 0345249 A1) were reviewed. Results: Endosymbiotic Wolbachia bacteria, which are inherited from mothers, is transmitted to mosquitoes and interferes with pathogen transmission. They can change the reproduction of their host. Wolbachia is transmitted through the cytoplasm of eggs and have evolved different mechanisms for manipulating the reproduction of its hosts, including the induction of reproductive incompatibility, parthenogenesis, and feminization. The extensive effects of Wolbachia on reproduction and host fitness have made Wolbachia the issue of growing attention as a potential biocontrol agent. Conclusion: Wolbachia has opened a new window to design a costly, potent and ecofriendly drug target for effective treatment and elimination of vector-borne parasitic diseases.

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Projected economic losses due to vector and vector-borne parasitic diseases in livestock of India and its significance in implementing the concept of integrated practices for vector management

Veterinary World ◽

10.14202/vetworld.2018.151-160 ◽

2018 ◽

Vol 11 (2) ◽

pp. 151-160 ◽

Cited By ~ 8

Author(s):

B. W. Narladkar

Keyword(s):

Economic Losses ◽

Parasitic Diseases ◽

Vector Management ◽

Vector Borne

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Establishment of a method for Lutzomyia longipalpis sand fly egg microinjection: The first step towards potential novel control strategies for leishmaniasis

Wellcome Open Research ◽

10.12688/wellcomeopenres.14555.2 ◽

2018 ◽

Vol 3 ◽

pp. 55

Author(s):

Claire L. Jeffries ◽

Matthew E. Rogers ◽

Thomas Walker

Keyword(s):

Control Strategies ◽

Sand Fly ◽

Parasitic Diseases ◽

Lutzomyia Longipalpis ◽

Early Generation ◽

Rapid Injection ◽

Novel Method ◽

Vector Borne ◽

Fly Control ◽

Zoonotic Visceral Leishmaniasis

Leishmaniases is a group of vector-borne parasitic diseases transmitted by sand flies that affects 1.3 million people across 98 countries, with limited control strategies due to the lack of an available vaccine and the emergence of insecticide resistance. Novel control strategies that are being explored for mosquito-borne diseases, such as Wolbachia bacterial inhibition of pathogens and genetically modified insects (e.g. using CRISPR-Cas9 editing), rely on the ability to consistently inject eggs of the target species. Here we present a novel method to obtain and inject preblastoderm sand fly eggs of the genus Lutzomyia (Lu.) longipalpis, the principle vector of zoonotic visceral leishmaniasis in South America. The procedures required to obtain sufficiently young Lu. longipalpis colony eggs are described alongside a microinjection technique that permits rapid injection and minimal handling of small sand fly eggs post-injection. Using a strain of Wolbachia as a ‘marker’ for successful injection, our protocol produced early generation Wolbachia transinfected Lu. longipalpis lines, demonstrating its potential as the first step for use in novel applied strategies for sand fly control.

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METHODOLOGICAL GUIDE ON DISINSECTION AND DISACARISATION IN THE CENTERS FOR INTRODUCTION AND REINTRODUCTION OF ANIMALS

Problems of Veterinary Sanitation, Hygiene and Ecology ◽

10.36871/vet.san.hyg.ecol.202103010 ◽

2021 ◽

Vol 1 (3) ◽

pp. 303-308

Author(s):

P.I. Khristianovsky ◽

◽

I.S. Ponomareva ◽

D.A. Grudinin ◽

E.N. Kuzmina ◽

...

Keyword(s):

Veterinary Medicine ◽

Parasitic Diseases ◽

Vector Borne Diseases ◽

Animal Diseases ◽

Blood Sucking ◽

Natural Foci ◽

Vector Borne ◽

The Russian Federation ◽

Scientific Station ◽

Academy Of Sciences

Introduction and reintroduction requires the movement of different groups of animals over considerable distances. In this case, there is a risk of the spread of infectious and parasitic diseases. The current veterinary rules and requirements contain instructions on measures for the import (movement) of zoo and circus animals, but there are no instructions on animals in protected areas. This paper proposes options for disinsection and disacarisation of various objects at the points of introduction and reintroduction of animals, based on the instructions approved by the Department of Veterinary Medicine of the Ministry of Agriculture of the Russian Federation. The work was carried out in connection with the need to develop recommendations to prevent the spread of infectious and invasive animal diseases, including anthropozoonoses, on the territory of the steppe scientific station of the Steppe Institute of the Ural Branch of the Russian Academy of Sciences «Orenburg Tarpania». One of the significant risks in the introduction of animals is the presence of natural foci of vector-borne diseases in the model area. To eliminate these risks, it is necessary to spray animals with insectoacaricides of the pyrethroid group when importing animals. At reintroduction points, carry out regular arachnoentomological monitoring of the area. With an increase in the number of blood-sucking arthropods, it is necessary to apply insectoacaricides by spraying biotopes. When a vector-borne disease appears, spray both biotopes and the animals themselves to break the epizootic chain.

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