scholarly journals Current understanding of glucose transporter 4 expression and functional mechanisms

2020 ◽  
Vol 11 (3) ◽  
pp. 76-98
Author(s):  
Tiannan Wang ◽  
Jing Wang ◽  
Xinge Hu ◽  
Xianju Huang ◽  
Guo-Xun Chen
Keyword(s):  
Glucose Transporter ◽  
Current Understanding ◽  
Glucose Transporter 4 ◽  
Functional Mechanisms

scholarly journals Antidiabetic and Antihyperlipidemic Effects ofClitocybe nudaon Glucose Transporter 4 and AMP-Activated Protein Kinase Phosphorylation in High-Fat-Fed Mice

2014 ◽  
Vol 2014 ◽  
pp. 1-14 ◽  
Author(s):  
Mei-Hsing Chen ◽  
Cheng-Hsiu Lin ◽  
Chun-Ching Shih
Keyword(s):  
Skeletal Muscle ◽  
Protein Kinase ◽  
Glucose Transporter ◽  
Body Weight Gain ◽  
Glucose Production ◽  
Hypolipidemic Effect ◽  
Glucose Transporter 4 ◽  
High Fat ◽  
Hepatic Expression ◽  
Amp Activated Protein Kinase

The objective of this study was to evaluate the antihyperlipidemic and antihyperglycemic effects and mechanism of the extract ofClitocybe nuda(CNE), in high-fat- (HF-) fed mice. C57BL/6J was randomly divided into two groups: the control (CON) group was fed with a low-fat diet, whereas the experimental group was fed with a HF diet for 8 weeks. Then, the HF group was subdivided into five groups and was given orally CNE (including C1: 0.2, C2: 0.5, and C3: 1.0 g/kg/day extracts) or rosiglitazone (Rosi) or vehicle for 4 weeks. CNE effectively prevented HF-diet-induced increases in the levels of blood glucose, triglyceride, insulin (P<0.001,P<0.01,P<0.05, resp.) and attenuated insulin resistance. By treatment with CNE, body weight gain, weights of white adipose tissue (WAT) and hepatic triacylglycerol content were reduced; moreover, adipocytes in the visceral depots showed a reduction in size. By treatment with CNE, the protein contents of glucose transporter 4 (GLUT4) were significantly increased in C3-treated group in the skeletal muscle. Furthermore, CNE reduces the hepatic expression of glucose-6-phosphatase (G6Pase) and glucose production. CNE significantly increases protein contents of phospho-AMP-activated protein kinase (AMPK) in the skeletal muscle and adipose and liver tissues. Therefore, it is possible that the activation of AMPK by CNE leads to diminished gluconeogenesis in the liver and enhanced glucose uptake in skeletal muscle. It is shown that CNE exhibits hypolipidemic effect in HF-fed mice by increasing ATGL expression, which is known to help triglyceride to hydrolyze. Moreover, antidiabetic properties of CNE occurred as a result of decreased hepatic glucose production via G6Pase downregulation and improved insulin sensitization. Thus, amelioration of diabetic and dyslipidemic states by CNE in HF-fed mice occurred by regulation of GLUT4, G6Pase, ATGL, and AMPK phosphorylation.

scholarly journals Quantitative Genetic Analysis of Glucose Transporter 4 mRNA Levels in Baboon Adipose**

2004 ◽  
Vol 12 (10) ◽  
pp. 1652-1657 ◽  
Author(s):  
M. Elizabeth Tejero ◽  
J. Michael Proffitt ◽  
Shelley A. Cole ◽  
Jeanne H. Freeland-Graves ◽  
Guowen Cai ◽  
...  
Keyword(s):  
Genetic Analysis ◽  
Glucose Transporter ◽  
Mrna Levels ◽  
Glucose Transporter 4 ◽  
Quantitative Genetic ◽  
Quantitative Genetic Analysis

scholarly journals A Pre-Docking Role for Microtubules in Insulin-Stimulated Glucose Transporter 4 Translocation

2010 ◽  
Vol 98 (3) ◽  
pp. 670a
Author(s):  
Yu Chen ◽  
Yan Wang ◽  
Wei Ji ◽  
Pingyong Xu ◽  
Tao Xu
Keyword(s):  
Glucose Transporter ◽  
Glucose Transporter 4

Endocytosis, Recycling, and Regulated Exocytosis of Glucose Transporter 4

Biochemistry ◽  
2011 ◽  
Vol 50 (15) ◽  
pp. 3048-3061 ◽  
Author(s):  
Kevin Foley ◽  
Shlomit Boguslavsky ◽  
Amira Klip
Keyword(s):  
Glucose Transporter ◽  
Glucose Transporter 4 ◽  
Regulated Exocytosis

Expression of glucose transporter 4 in the human pancreatic islet of Langerhans

2004 ◽  
Vol 314 (4) ◽  
pp. 1121-1125 ◽  
Author(s):  
Honami Kobayashi ◽  
Takashi Mitsui ◽  
Seiji Nomura ◽  
Yasumasa Ohno ◽  
Kenji Kadomatsu ◽  
...  
Keyword(s):  
Pancreatic Islet ◽  
Glucose Transporter ◽  
Islet Of Langerhans ◽  
Glucose Transporter 4 ◽  
Human Pancreatic Islet

scholarly journals Metabolic Profiling of Hearts Exposed to Sevoflurane and Propofol Reveals Distinct Regulation of Fatty Acid and Glucose Oxidation

2010 ◽  
Vol 113 (3) ◽  
pp. 541-551 ◽  
Author(s):  
Lianguo Wang ◽  
Kerry W. S. Ko ◽  
Eliana Lucchinetti ◽  
Liyan Zhang ◽  
Heinz Troxler ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Energy Metabolism ◽  
Lipid Rafts ◽  
Metabolic Profiling ◽  
Glucose Oxidation ◽  
Molecular Mechanisms ◽  
Glucose Transporter ◽  
Left Ventricular ◽  
Glucose Transporter 4 ◽  
Oxidative Energy Metabolism

Background Myocardial energy metabolism is a strong predictor of postoperative cardiac function. This study profiled the metabolites and metabolic changes in the myocardium exposed to sevoflurane, propofol, and Intralipid and investigated the underlying molecular mechanisms. Methods Sevoflurane (2 vol%) and propofol (10 and 100 microM) in the formulation of 1% Diprivan (AstraZeneca Inc., Mississauga, ON, Canada) were compared for their effects on oxidative energy metabolism and contractility in the isolated working rat heart model. Intralipid served as a control. Substrate flux through the major pathways for adenosine triphosphate generation in the heart, that is, fatty acid and glucose oxidation, was measured using [H]palmitate and [C]glucose. Biochemical analyses of nucleotides, acyl-CoAs, ceramides, and 32 acylcarnitine species were used to profile individual metabolites. Lipid rafts were isolated and used for Western blotting of the plasma membrane transporters CD36 and glucose transporter 4. Results Metabolic profiling of the hearts exposed to sevoflurane and propofol revealed distinct regulation of fatty acid and glucose oxidation. Sevoflurane selectively decreased fatty acid oxidation, which was closely related to a marked reduction in left ventricular work. In contrast, propofol at 100 microM but not 10 microM increased glucose oxidation without affecting cardiac work. Sevoflurane decreased fatty acid transporter CD36 in lipid rafts/caveolae, whereas high propofol increased pyruvate dehydrogenase activity without affecting glucose transporter 4, providing mechanisms for the fuel shifts in energy metabolism. Propofol increased ceramide formation, and Intralipid increased hydroxy acylcarnitine species. Conclusions Anesthetics and their solvents elicit distinct metabolic profiles in the myocardium, which may have clinical implications for the already jeopardized diseased heart.

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