scholarly journals Darier’s Disease: Two Familial Case Reports

2015 ◽  
Vol 06 (Supplement 6) ◽  
Keyword(s):  
Case Reports ◽  
Familial Case ◽  
Darier’S Disease ◽  
Darier's Disease

Therapeutic Options for the Treatment of Darier’s Disease: A Comprehensive Review of the Literature

2021 ◽  
pp. 120347542110584
Author(s):  
N. Hanna ◽  
M. Lam ◽  
P. Fleming ◽  
C. Lynde
Keyword(s):  
English Language ◽  
Case Reports ◽  
Case Series ◽  
Surgical Excision ◽  
Therapeutic Options ◽  
Keratosis Follicularis ◽  
Darier’S Disease ◽  
Dyskeratosis Follicularis ◽  
Darier's Disease ◽  
Oral Isotretinoin

Darier’s disease (also known as keratosis follicularis or dyskeratosis follicularis) is an autosomal dominant inherited disorder which manifests as hyperkeratotic greasy papules in the first or second decade of life. Aside from symptom management and behavioral modifications to avoid triggers, there are currently no validated treatments for Darier’s disease (DD). However, a variety of treatments have been proposed in the literature including retinoids, steroids, vitamin D analogs, photodynamic therapy, and surgical excision. The purpose of this review article is to identify therapeutic options for treating DD and to outline the evidence underlying these interventions. A search was conducted in Medline for English language articles from inception to July 4, 2020. Our search identified a total of 474 nonduplicate studies, which were screened by title and abstract. Of these, 155 full text articles were screened against inclusion/exclusion criteria, and 113 studies were included in our review. We identified Grade B evidence for the following treatments of DD: oral acitretin, oral isotretinoin, systemic Vitamin A, topical tretinoin, topical isotretinoin, topical adapalene gel, topical 5-flououracil, topical calciptriol and tacalcitol (with sunscreen), grenz ray radiation, and x-ray radiation. All other evidence for treatments of DD consisted of case reports or case series, which is considered grade C evidence. Considering the quality and quantity of evidence, clinicians may consider initiating a trial of select topical or oral retinoids first in patients with localized or generalized DD, respectively.

scholarly journals Familial case of Darier’s disease: A rare genodermatosis

2020 ◽  
Vol 8 (1) ◽  
pp. 55-57
Author(s):  
Mohammad Kamrul Ahsan ◽  
M Moniruzzaman Khan ◽  
Mir Nazrul Islam
Keyword(s):  
Autosomal Dominant ◽  
Histopathological Examination ◽  
Whole Body ◽  
Familial Case ◽  
Keratosis Follicularis ◽  
Darier’S Disease ◽  
Darier's Disease ◽  
Initial Stage ◽  
Good Improvement

Darier’s disease, also known as keratosis follicularis is a rare autosomal dominant inherited genodermatosis characterized by abnormal keratinization . A 39-year old non-diabetic, normotensive man presented to dermatology OPD with discretely distributed dark brown greasy, warty, malodorous, hyperkeratotic papules over his whole body for last 15 years. He has two young daughters and both has started initial stage of similar lesions for last 6 months. Characteristic v-shaped nicking at the tip of the nails with longitudinal red & white ridges were seen. Nails at the distal ends were broken. Biopsy of skin for histopathological examination showed more specific and confirmatory ‘corps ronds and grains’. This article reports a case of familial darier’s disease. Good improvement was noticed after acitretin therapy. Bangladesh Crit Care J March 2020; 8(1): 55-57

Hemorrhagic Darier's disease

1993 ◽  
Vol 129 (4) ◽  
pp. 511-512 ◽  
Author(s):  
P. L. Foresman
Keyword(s):  
Darier’S Disease ◽  
Darier's Disease

Hailey-Hailey Disease with Hyperkeratotic Verrucus Lesions (Similar to Darier's Disease): A Case Report.

1992 ◽  
Vol 54 (6) ◽  
pp. 1074-1078
Author(s):  
Toshiki ITOH ◽  
Youichi INABA ◽  
Takehiko NAKAMURA ◽  
Tomomichi ONO
Keyword(s):  
Case Report ◽  
Darier’S Disease ◽  
Darier's Disease

A Japanese case of segmental Darier's disease caused by mosaicism for the ATP2A2 mutation

2003 ◽  
Vol 149 (1) ◽  
pp. 185-188 ◽  
Author(s):  
T. Wada ◽  
Y. Shirakata ◽  
H. Takahashi ◽  
S. Murakami ◽  
H. Iizuka ◽  
...  
Keyword(s):  
Japanese Case ◽  
Darier’S Disease ◽  
Darier's Disease

A novel POU1F1 pathogenic variant: Two familial case reports with phenotype expansion

2021 ◽  
Author(s):  
Noha Musa ◽  
Mohamed A. Elmonem ◽  
Christian Beetz ◽  
Mona Hafez ◽  
Mona Hassan ◽  
...  
Keyword(s):  
Case Reports ◽  
Pathogenic Variant ◽  
Familial Case
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