scholarly journals The Effect of Erythropoietin on S100 Protein Expression in Cochlea After Acoustic Overstimulation: An Experimental Study

2015 ◽  
Vol 6 (3) ◽  
Author(s):  
Seren Gulsen Gurgen
Keyword(s):  
Experimental Study ◽  
Protein Expression ◽  
S100 Protein ◽  
Acoustic Overstimulation

scholarly journals Case Reports in Oncological Medicine Myoepithelioma: A New Rearrangement Involving the LPP Locus in a Case of Multiple Bone and Soft Tissue Lesions

2018 ◽  
Vol 2018 ◽  
pp. 1-6
Author(s):  
Géraldine Pairet ◽  
Gaëlle Tilman ◽  
Rafaël Sciot ◽  
Thomas Schubert ◽  
Vasiliki Perlepe ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Protein Expression ◽  
Case Reports ◽  
S100 Protein ◽  
Soft Tissue Tumors ◽  
Molecular Karyotyping ◽  
Genomic Alteration ◽  
Navicular Bone ◽  
Mesenchymal Tumors ◽  
Epithelial Markers

We report a case of multiple myoepithelioma with synchronous bone and soft tissue tumors, associated with a new genomic alteration of the LPP locus. The lesions occurred in the foot by presenting one lump in the plantar soft tissue, and three lesions were detected in the calcaneus and in the navicular bone. All tumors showed the double immunophenotype of epithelial markers and S100 protein expression. No rearrangement of the EWSR1 and FUS loci was detected as reported in myoepitheliomas. However, molecular karyotyping detected an unbalanced rearrangement of the LPP locus, not involving the HMGA2 locus, which is the most frequent translocation partner observed in benign mesenchymal tumors such as lipomas (of soft tissue as well as parosteal) and pulmonary chondroid hamartoma.

scholarly journals A Distinct Malignant Epithelioid Neoplasm With GLI1 Gene Rearrangements, Frequent S100 Protein Expression, and Metastatic Potential

2018 ◽  
Vol 42 (4) ◽  
pp. 553-560 ◽  
Author(s):  
Cristina R. Antonescu ◽  
Narasimhan P. Agaram ◽  
Yun-Shao Sung ◽  
Lei Zhang ◽  
David Swanson ◽  
...  
Keyword(s):  
Protein Expression ◽  
S100 Protein ◽  
Metastatic Potential ◽  
Gene Rearrangements

scholarly journals A Surgically Resected Pancreatic Schwannoma with Obstructive Jaundice with Special Reference to Differential Diagnosis from Other Cystic Lesions in the Pancreas

2018 ◽  
Vol 12 (1) ◽  
pp. 85-91 ◽  
Author(s):  
Takayoshi Watanabe ◽  
Kenichiro Araki ◽  
Norihiro Ishii ◽  
Takamichi Igarashi ◽  
Akira Watanabe ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Obstructive Jaundice ◽  
Protein Expression ◽  
Histopathological Examination ◽  
S100 Protein ◽  
Pancreatic Head ◽  
Pancreatic Tumors ◽  
Cystic Lesions ◽  
Cystic Tumors ◽  
Pancreatic Schwannoma

Pancreatic schwannomas are uncommon. About 60% of pancreatic schwannomas develop cystic lesions, and the differential diagnosis from other cystic pancreatic tumors is difficult. A 43-year-old man presented for evaluation of liver dysfunction detected during a medical checkup. Blood testing detected obstructive jaundice. A computed tomography scan revealed a well-defined polycystic tumor of about 5 cm at the pancreatic head. We performed surgical resection to treat the patient’s symptoms and facilitate long-term management. Histopathological examination revealed spindle-shaped cells. Immunohistochemical studies showed S100 protein expression and the absence of CD34 and c-kit protein expression. Finally, we diagnosed a schwannoma. Pancreatic schwannoma is usually asymptomatic. The present case presented with obstructive jaundice, which is reportedly a rare symptom. Pancreatic schwannomas should be considered as a differential diagnosis of pancreatic cystic tumors. Dilatation of the pancreatic duct and the 18-fluorodeoxyglucose positron emission tomography findings are important for the differential diagnosis.

scholarly journals S100A4 May Be a Good Prognostic Marker and a Therapeutic Target for Colon Cancer

2018 ◽  
Vol 2018 ◽  
pp. 1-8 ◽  
Author(s):  
Sabahattin Destek ◽  
Vahit Onur Gul
Keyword(s):  
Colon Cancer ◽  
Protein Expression ◽  
Tumor Progression ◽  
Tumor Tissue ◽  
Patient Survival ◽  
S100 Protein ◽  
Prognostic Significance ◽  
Tnm Staging ◽  
Expression Levels ◽  
S100a4 Protein

Background. Globally, the colorectal cancers rank the third in terms of cancer incidence and rank the fourth in cancer-associated deaths. S100A4, an important member of the S100 protein family, serves to promote tumor progression and metastasis. By conducting this study, we aim to examine the role of S100A4 in the prognosis of colon cancer and to demonstrate its prognostic significance. Methods. Tissue samples of colon cancer from 148 patients who underwent colon resection due to colon cancer were analyzed by immunohistochemical staining to determine the protein expression levels of S100A4. The protein expression levels of S100A4 in tumor tissue were matched with the clinicopathologic factors including patient survival. Results. Cytoplasmic expression of S100A4 protein was demonstrated in the tumor tissue of 132 patients (89.2%) out of a total of 148 study patients. Statistically, the expression levels of the cytoplasmic S100A4 protein correlated significantly with the TNM stages and patient survival. The distribution of the S100A4 protein staining in the tumor tissue was associated with the age groups, tumor localization, TNM staging, and patient survival with statistical significance. The levels of S100A4 protein expression were found to be an independent prognostic factor for TNM staging and poor survival. Conclusion. Expression of the S100A4 protein in colon cancers may be an indicator of tumor progression and lymph node metastasis and may be useful for predicting the overall survival of the patients with colon cancer. In patients with colon cancer, it may be used as an indicator of poor prognosis.

Clinicopathological significance of S100 protein expression in cholangiocarcinoma

2013 ◽  
Vol 28 (8) ◽  
pp. 1422-1429 ◽  
Author(s):  
Yasunori Sato ◽  
Kenichi Harada ◽  
Motoko Sasaki ◽  
Yasuni Nakanuma
Keyword(s):  
Protein Expression ◽  
S100 Protein ◽  
Clinicopathological Significance

scholarly journals Comparative Proteomic Analysis of Human Cholangiocarcinoma Cell Lines: S100A2 as a Potential Candidate Protein Inducer of Invasion

2015 ◽  
Vol 2015 ◽  
pp. 1-6 ◽  
Author(s):  
Kasima Wasuworawong ◽  
Sittiruk Roytrakul ◽  
Atchara Paemanee ◽  
Kattaleeya Jindapornprasert ◽  
Waraporn Komyod
Keyword(s):  
Protein Expression ◽  
Cell Lines ◽  
Calcium Binding ◽  
Expression Profiles ◽  
S100 Protein ◽  
Potential Candidate ◽  
Proteomic Data ◽  
Potential Biomarker ◽  
Cholangiocarcinoma Cell ◽  
Protein Expression Profiles

Cholangiocarcinoma (CCA) is a bile duct cancer, commonly found in Asia including Thailand and especially in the northeastern region of Thailand. To identify the proteins involved in carcinogenesis and metastasis of CCA, protein expression profiles of high-invasive KKU-M213 and low-invasive KKU-100 cell lines were compared using a comparative GeLC-MS/MS proteomics analysis. A total of 651 differentially expressed proteins were detected of which 27 protein candidates were identified as having functions involved in cell motility. A total of 22 proteins were significantly upregulated in KKU-M213, whereas 5 proteins were downregulated in KKU-M213. S100A2, a calcium-binding protein in S100 protein family, is upregulated in KKU-M213. S100A2 is implicated in metastasis development in several cancers. The protein expression level of S100A2 was verified by Western blot analysis. Intriguingly, high-invasive KKU-M213 cells showed higher expression of S100A2 than KKU-100 cells, consistent with proteomic data, suggesting that S100A2 may be a key protein involved in the progression of CCA. However, the biological function of S100A2 in cholangiocarcinoma remains to be elucidated. S100A2 might be a potential biomarker as well as a novel therapeutic target in CCA metastasis.

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