scholarly journals The impact of imiquimod on radiation-induced lung injury: Results of an experimental study

2019 ◽  
Vol 10 (6) ◽  
Author(s):  
Mustafa Calik
Keyword(s):  
Experimental Study ◽  
Lung Injury ◽  
Radiation Induced ◽  
The Impact

The impact of pre-radiotherapy surgical intervention on radiation-induced lung injury

2004 ◽  
Vol 22 (14_suppl) ◽  
pp. 7274-7274
Author(s):  
L. B. Marks ◽  
Z. Kocak ◽  
X. Yu ◽  
S. Zhou ◽  
D. Hollis ◽  
...  
Keyword(s):  
Lung Injury ◽  
Surgical Intervention ◽  
Radiation Induced ◽  
The Impact

scholarly journals Protective Effects of Myrtol Standardized Against Radiation-Induced Lung Injury

2016 ◽  
Vol 38 (2) ◽  
pp. 619-634 ◽  
Author(s):  
De-yun Zhao ◽  
Hong-jin Qu ◽  
Jia-ming Guo ◽  
Hai-nan Zhao ◽  
Yan-yong Yang ◽  
...  
Keyword(s):  
Single Dose ◽  
Lung Injury ◽  
Major Complication ◽  
The Body ◽  
Protective Effects ◽  
Western Blot Assay ◽  
Tnf Α ◽  
Radiation Induced ◽  
The Impact ◽  
Tgf Β1

Background/Aims: As a major complication after thoracic radiotherapy, radiation-induced lung injury (RILI) has great impact on long term quality of life and could result in fatal respiratory insufficiency The present study was aimed to evaluate the effects of Myrtol standardized on RILI, and to investigate the underlying mechanism. Methods: A mouse model of radiation-induced lung injury was generated by using thoracic irradiation with a single dose of 16Gy. Mice were orally administrated with Myrtol (25 mg/kg/day) for 4 weeks after irradiation, while prednisone (5 mg/kg/day) was used as a positive control. After then, the body weight and lung coefficient were calculated. The severity of fibrosis was evaluated by observing pulmonary sections after radiation and collagen content in lung tissues was calculated following the hydroxyproline (HYP) assay. Pathological changes were observed in all the groups by using HE staining and Masson staining. The serum levels of TGF-β1, TNF-α, IL-1β, IL-6, and PGE2 were also measured with an ELISA assay. Western blot assay was used to measure the impact of Myrtol on AKT and its downstream signaling pathway, including MMP-2 and MMP-9. The levels of Vimentin and α-SMA were evaluated with an immunofluorescence assay. Results: Treatment with Myrtol standardized, but not prednisone, reduced lung coefficient and collagen deposition in lung tissues, while attenuated histological damages induced by irradiation. Myrtol standardized also reduced the production of MDA, while increased the level of SOD. It was also observed that Myrtol standardized inhibited TGF-β1 and a series of pro-inflammatory cytokines including TNF-α, IL-1β, IL-6, PGE2. While in prednisone group, even though the early pneumonitis was ameliorated, the collagen disposition remained unchanged in latter times. Immunofluorescence analysis also revealed elevation of vimentin and α-SMA in the alveoli after a single dose of 16Gy. Conclusion: The present results suggest Myrtol standardized as an effective agent for attenuating the lung injury induced by irradiation.

scholarly journals Protection Against Radiation-induced Duox1 and Duox2 Upregulation in Rat’s Lung Tissues by a Combination of Curcumin and L-Selenomethionine

2021 ◽  
Vol In Press (In Press) ◽  
Author(s):  
Masoud Najafi ◽  
Peyman Amini ◽  
Hana Saffar ◽  
Sedighe Kolivand ◽  
Elahe Motevaseli ◽  
...  
Keyword(s):  
Experimental Study ◽  
Free Radicals ◽  
Lung Injury ◽  
Male Rats ◽  
Interleukin 4 ◽  
Injury Treatment ◽  
Radiation Induced ◽  
Lung Irradiation ◽  
Stimulation Of

Background: It has been proposed that increased levels of pro-inflammatory and pro-fibrotic cytokines play a key role in radiation-induced lung injury. Interleukin-4 (IL-4) and IL-13 are two pro-fibrotic cytokines that promote the production of free radicals through stimulation of Duox1 and Duox2. In this experimental study, we aimed to evaluate the expression of IL4Ra1, Duox1, IL13Ra2, and Duox2 genes following rat’s lung irradiation. Objectives: Also, we detected the modulatory effect of a combination of curcumin and L-selenomethionine on the expression of these genes. Methods: Twenty male rats were divided into four groups as G1: control (no treatment or radiation); G2: treatment with a combination of curcumin and L-selenomethionine; G3: radiation; G4: radiation plus a combination of curcumin and L-selenomethionine. sixty-seven days after irradiation, rats were killed for detecting the expression of IL4Ra1, IL13Ra2, Duox1, and Duox2. Results: The results showed no detectable expression for IL13Ra2, while the expression of IL4Ra1, Duox1, and Duox2 was increased. Treatment with a combination of curcumin and L-selenomethionine could attenuate the expression of these genes. Conclusions: This study proposes that upregulation of Duox1 and Duox2 may be involved in radiation-induced lung injury. Treatment with a combination of curcumin and L-selenomethionine may be useful for the mitigation of lung injury through modulation of these genes.

The impact of pre-radiotherapy surgery on radiation-induced lung injury

2005 ◽  
Vol 17 (4) ◽  
pp. 210-216 ◽  
Author(s):  
Z. Kocak ◽  
X. Yu ◽  
S.-M. Zhou ◽  
T.A. D'Amico ◽  
D. Hollis ◽  
...  
Keyword(s):  
Lung Injury ◽  
Radiation Induced ◽  
The Impact

The impact of pre-radiotherapy surgical intervention on radiation-induced lung injury

2004 ◽  
Vol 22 (14_suppl) ◽  
pp. 7274-7274
Author(s):  
L. B. Marks ◽  
Z. Kocak ◽  
X. Yu ◽  
S. Zhou ◽  
D. Hollis ◽  
...  
Keyword(s):  
Lung Injury ◽  
Surgical Intervention ◽  
Radiation Induced ◽  
The Impact

The impact of trastuzumab on radiation-induced pulmonary fibrosis: results of an experimental study

2009 ◽  
Vol 27 (4) ◽  
pp. 1415-1419 ◽  
Author(s):  
N. S. Bese ◽  
C. Umay ◽  
S. Serdengecti ◽  
N. Kepil ◽  
N. Sut ◽  
...  
Keyword(s):  
Experimental Study ◽  
Pulmonary Fibrosis ◽  
Radiation Induced ◽  
The Impact

Experimental study of thermohydraulic characteristics and irreversibility analysis of novel axial corrugated tube with spring tape inserts

2020 ◽  
Vol 92 (3) ◽  
pp. 30901
Author(s):  
Suvanjan Bhattacharyya ◽  
Debraj Sarkar ◽  
Ulavathi Shettar Mahabaleshwar ◽  
Manoj K. Soni ◽  
M. Mohanraj
Keyword(s):  
Heat Transfer ◽  
Experimental Study ◽  
Thermal Performance ◽  
Working Fluid ◽  
The Novel ◽  
Heat Exchanger Tube ◽  
Heat Transfer Augmentation ◽  
Corrugated Tube ◽  
The Impact ◽  
Exchanger Tube

The current study experimentally investigates the heat transfer augmentation on the novel axial corrugated heat exchanger tube in which the spring tape is introduced. Air (Pr = 0.707) is used as a working fluid. In order to augment the thermohydraulic performance, a corrugated tube with inserts is offered. The experimental study is further extended by varying the important parameters like spring ratio (y = 1.5, 2.0, 2.5) and Reynolds number (Re = 10 000–52 000). The angular pitch between the two neighboring corrugations and the angle of the corrugation is kept constant through the experiments at β = 1200 and α = 600 respectively, while two different corrugations heights (h) are analyzed. While increasing the corrugation height and decreasing the spring ratio, the impact of the swirling effect improves the thermal performance of the system. The maximum thermal performance is obtained when the corrugation height is h = 0.2 and spring ratio y = 1.5. Eventually, correlations for predicting friction factor (f) and Nusselt number (Nu) are developed.

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