scholarly journals Cholesterol-Lowering Effects of Soy Protein Peptic Hydrolysate with Bound Phospholipids in Rats. Cross-over Test, Dose-Response Test, and Comparison with Materials Possessing Cholesterol-Lowering Effects.

1999 ◽  
Vol 52 (4) ◽  
pp. 183-191 ◽  
Author(s):  
Koji Morishita ◽  
Kazuhiro Yamamoto ◽  
Goro Hori ◽  
Miho Tanaka ◽  
Toshikazu Kamiya ◽  
...  
Keyword(s):  
Dose Response ◽  
Soy Protein ◽  
Test Dose ◽  
Cholesterol Lowering ◽  
Response Test

Elicitation threshold of cobalt chloride: analysis of patch test dose-response studies

2015 ◽  
Vol 74 (2) ◽  
pp. 105-109 ◽  
Author(s):  
Louise A. Fischer ◽  
Jeanne D. Johansen ◽  
Aage Voelund ◽  
Carola Lidén ◽  
Anneli Julander ◽  
...  
Keyword(s):  
Patch Test ◽  
Dose Response ◽  
Cobalt Chloride ◽  
Test Dose

scholarly journals Soy Protein Enhances the Cholesterol-Lowering Effect of Plant Sterol Esters in Cholesterol-Fed Hamsters

2004 ◽  
Vol 134 (1) ◽  
pp. 143-148 ◽  
Author(s):  
Yuguang Lin ◽  
Gert W. Meijer ◽  
Mario A. Vermeer ◽  
Elke A. Trautwein
Keyword(s):  
Soy Protein ◽  
Plant Sterol ◽  
Sterol Esters ◽  
Cholesterol Lowering ◽  
Lowering Effect ◽  
Cholesterol Lowering Effect

CLINICAL TRIAL OF HUMAN GONADOTROPHINS

1966 ◽  
Vol 53 (3_Suppl) ◽  
pp. S3-S26 ◽  
Author(s):  
A. C. Crooke ◽  
W. R. Butt ◽  
P. V. Bertrand
Keyword(s):  
Clinical Trial ◽  
Dose Response ◽  
Positive Response ◽  
Test Dose ◽  
Sufficient Data ◽  
Response Relationship ◽  
Dose Response Relationship ◽  
Individual Sensitivity ◽  
The Difference ◽  
The Times

ABSTRACT Thirteen patients with prolonged secondary amenorrhoea and 5 with anovular cycles each provided sufficient data to establish their individual sensitivity to FSH. The parameters used were based on the rise in excretion of oestriol and of pregnanediol. The sensitivity expressed as the ED 50 (that dose which is effective in 50 per cent of times it is given) varied between patients over at least a sevenfold range but the difference between the 2 groups of patients was not significant. After adjusting for differences between patients a dose-response relationship was established and it was found that a dose equal to half the ED 50 would be expected to produce a response in less than Io per cent of the times it is given while a dose equal to twice the ED 50 would be expected to produce a response in more than go per cent of the times it is given. Such a dose would be likely to produce an excessive response. An excessive response occurred three times in 140 months of treatment. Sixteen of the I8 patients became pregnant. The 2 who failed gave up treatment prematurely. A test of individual patient's sensitivity to FSH was established which depended on single injections of the hormone mixed with HCG. The test was repeated at 2 to 3 weekly intervals with increasing dosages until a positive response was obtained as judged by an increase in excretion of oestriol. The rate at which the dose should be increased was investigated and a 30 per cent rate was selected. When the effective test dose was established a standard schedule of dosages was recommended for treatment using 3 equal doses of FSH in 8 days and HCG on the tenth.

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