Prenatal Detection of Neural Tube Defects

2019 ◽  
pp. 75-87
Author(s):  
Aubrey Milunsky ◽  
Tamah L. Sadick
Keyword(s):  
Neural Tube ◽  
Neural Tube Defects ◽  
Prenatal Detection

Detection of spina bifida in the first trimester of gestation in association with triploidy

2017 ◽  
Author(s):  
K.K. Otaryan , C.G. Gagaev
Keyword(s):  
Spina Bifida ◽  
Early Detection ◽  
Neural Tube ◽  
Neural Tube Defects ◽  
First Trimester ◽  
Termination Of Pregnancy ◽  
Diagnostic Tools ◽  
Prenatal Detection ◽  
Post Abortion

The case of prenatal detection of spina bifida at 12+3 weeks of gestation is described. Termination of pregnancy was performed at 13+3 weeks. Post-abortion karyotyping revealed triploidy (69XXX). Diagnostic tools for early detection of neural tube defects in the 1st trimester of gestation and subsequent appropriate management of pregnancy are discussed.

Evolution of prenatal detection of neural tube defects in the pregnant population of the city of Barcelona from 1992 to 2006

2011 ◽  
Vol 31 (12) ◽  
pp. 1184-1188 ◽  
Author(s):  
Joaquín Salvador ◽  
Marta Arigita ◽  
Elena Carreras ◽  
Anna Lladonosa ◽  
Antoni Borrell
Keyword(s):  
Neural Tube ◽  
Neural Tube Defects ◽  
Prenatal Detection ◽  
The City

Prenatal Detection of Neural Tube Defects

JAMA ◽  
1980 ◽  
Vol 244 (24) ◽  
pp. 2731 ◽  
Author(s):  
Aubrey Milunsky
Keyword(s):  
Neural Tube ◽  
Neural Tube Defects ◽  
Prenatal Detection

Prenatal detection of neural tube defects

1975 ◽  
Vol 122 (3) ◽  
pp. 313-315 ◽  
Author(s):  
Aubrey Milunsky ◽  
James N. Macri ◽  
Robert R. Weiss ◽  
Elliot Alpert ◽  
Donald G. McIsaac ◽  
...  
Keyword(s):  
Neural Tube ◽  
Neural Tube Defects ◽  
Prenatal Detection

Prenatal detection of neural tube defects: False positive and negative results

PEDIATRICS ◽  
1977 ◽  
Vol 59 (5) ◽  
pp. 782-783
Author(s):  
Aubrey Milunsky
Keyword(s):  
Amniotic Fluid ◽  
Neural Tube ◽  
Neural Tube Defects ◽  
Fetal Liver ◽  
The United States ◽  
Prenatal Detection ◽  
Negative Results ◽  
The Family ◽  
Fetal Serum ◽  
Fetal Urine

An estimated 6,000 to 8,000 babies with neural tube defects (NTDs) are born each year in the United States. The suffering of both child and family has been well documented.1-3 Prenatal detection early in the second trimester of pregnancy became possible in 1972 when elevated α-fetoprotein (AFP) concentrations in amniotic fluid in association with open NTDs were demonstrated in Edinburgh.4 These results have been amply confirmed.5-10 The AFP test is best used and most reliable between 14 to 16 weeks of gestation.8 With such prenatal diagnosis, termination of the abnormal pregnancy can be offered to the family. AFP is synthesized by the yolk sac and fetal liver and normally passes from the fetal serum into fetal urine and then into the amniotic fluid.

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