Major Infectious Diseases Causing Excess Morbidity in the Hispanic Population

2019 ◽  
pp. 76-96
Author(s):  
Ciro V. Sumaya
Keyword(s):  
Infectious Diseases ◽  
Hispanic Population ◽  
Excess Morbidity

scholarly journals CRISPR-Cas Biology and Its Application to Infectious Diseases

2018 ◽  
Vol 57 (4) ◽  
Author(s):  
Jeffrey R. Strich ◽  
Daniel S. Chertow
Keyword(s):  
Infectious Diseases ◽  
Adaptive Immune System ◽  
Biomedical Science ◽  
Adaptive Immune ◽  
Disease Outcomes ◽  
Excess Morbidity ◽  
Efficient Gene ◽  
Global Threat ◽  
Human Infections ◽  
Cas Proteins

ABSTRACT Infectious diseases remain a global threat contributing to excess morbidity and death annually, with the persistent potential for destabilizing pandemics. Improved understanding of the pathogenesis of bacteria, viruses, fungi, and parasites, along with rapid diagnosis and treatment of human infections, is essential for improving infectious disease outcomes worldwide. Genomic loci in bacteria and archaea, termed clustered regularly interspaced short palindromic repeats (CRISPR) and CRISPR-associated (Cas) proteins, function as an adaptive immune system for prokaryotes, protecting them against foreign invaders. CRISPR-Cas9 technology is now routinely applied for efficient gene editing, contributing to advances in biomedical science. In the past decade, improved understanding of other diverse CRISPR-Cas systems has expanded CRISPR applications, including in the field of infectious diseases. In this review, we summarize the biology of CRISPR-Cas systems and discuss existing and emerging applications to evaluate mechanisms of host-pathogen interactions, to develop accurate and portable diagnostic tests, and to advance the prevention and treatment of infectious diseases.

Infectious Diseases in the Geriatric Patient

1982 ◽  
Vol 15 (2) ◽  
pp. 421-438 ◽  
Author(s):  
John G. Corcoran ◽  
Stanton G. Axline
Keyword(s):  
Infectious Diseases ◽  
Geriatric Patient

Factorial Invariance of Child Self-Report Across English and Spanish Language Groups in a Hispanic Population Utilizing the PedsQL™ 4.0 Generic Core Scales

2010 ◽  
Vol 26 (3) ◽  
pp. 194-202 ◽  
Author(s):  
Daniel A. Newman ◽  
Christine A. Limbers ◽  
James W. Varni
Keyword(s):  
Health Care Services ◽  
Factor Model ◽  
Five Factor Model ◽  
Well Being ◽  
Factorial Invariance ◽  
Spanish Language ◽  
Self Report ◽  
Hispanic Population ◽  
Language Groups ◽  
Related Quality

The measurement of health-related quality of life (HRQOL) in children has witnessed significant international growth over the past decade in an effort to improve pediatric health and well-being, and to determine the value of health-care services. In order to compare international HRQOL research findings across language groups, it is important to demonstrate factorial invariance, i.e., that the items have an equivalent meaning across the language groups studied. This study examined the factorial invariance of child self-reported HRQOL across English- and Spanish-language groups in a Hispanic population of 2,899 children ages 8–18 utilizing the 23-item PedsQL™ 4.0 Generic Core Scales. Multigroup confirmatory factor analysis (CFA) was performed specifying a five-factor model across language groups. The findings support an equivalent 5-factor structure across English- and Spanish-language groups. Based on these data, it can be concluded that children across the two languages studied interpreted the instrument in a similar manner. The multigroup CFA statistical methods utilized in the present study have important implications for cross-cultural assessment research in children in which different language groups are compared.

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