Developmental origins of the dialogical self

Author(s):  
Marie-Cécile Bertau
2021 ◽  
Vol 22 (5) ◽  
pp. 2298
Author(s):  
Chien-Ning Hsu ◽  
You-Lin Tain

The renin-angiotensin-aldosterone system (RAAS) is implicated in hypertension and kidney disease. The developing kidney can be programmed by various early-life insults by so-called renal programming, resulting in hypertension and kidney disease in adulthood. This theory is known as developmental origins of health and disease (DOHaD). Conversely, early RAAS-based interventions could reverse program processes to prevent a disease from occurring by so-called reprogramming. In the current review, we mainly summarize (1) the current knowledge on the RAAS implicated in renal programming; (2) current evidence supporting the connections between the aberrant RAAS and other mechanisms behind renal programming, such as oxidative stress, nitric oxide deficiency, epigenetic regulation, and gut microbiota dysbiosis; and (3) an overview of how RAAS-based reprogramming interventions may prevent hypertension and kidney disease of developmental origins. To accelerate the transition of RAAS-based interventions for prevention of hypertension and kidney disease, an extended comprehension of the RAAS implicated in renal programming is needed, as well as a greater focus on further clinical translation.


Societies ◽  
2021 ◽  
Vol 11 (3) ◽  
pp. 84
Author(s):  
Chiara Imperato ◽  
Tiziana Mancini

The effects of intergroup dialogues on intercultural relations in digital societies and the growing conflict, inflammatory and hate speech phenomena characterizing these environments are receiving increasing attention in socio-psychological studies. Based on Allport’s contact theory, scholars have shown that online intercultural contact reduces ethnic prejudice and discrimination, although it is not yet clear when and how this occurs. By analyzing the role of the Dialogical Self in online intercultural dialogues, we aim to understand how individuals position themselves and others at three levels of inclusiveness—personal, social, and human—and how this process is associated with attitudes towards the interlocutor, intergroup bias and prejudice, whilst also considering the inclusion of the Other in the Self and ethnic/racial identity. An experimental procedure was administered via the Qualtrics platform, and data were collected among 118 undergraduate Italian students through an anonymous questionnaire. From ANOVA and moderation analysis, it emerged that the social level of inclusiveness was positively associated with ethnic/racial identity and intergroup bias. Furthermore, the human level of inclusiveness was associated with the inclusion of the Other in the Self and ethnic/racial identity, and unexpectedly, also with intergroup bias. We conclude that when people interact online as “human beings”, the positive effect of online dialogue fails, hindering the differentiation processes necessary to define one’s own and the interlocutor’s identities. We discuss the effects of intercultural dialogue in the landscape of digital societies and the relevance of our findings for theory, research and practice.


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