scholarly journals Pupil Segmentation Using Orientation Fields, Radial Non-Maximal Suppression and Elliptic Approximation

2019 ◽  
Vol 19 (2) ◽  
pp. 69-74
Author(s):  
S. LEE ◽  
D. LEE ◽  
Y. PARK
Keyword(s):  
Orientation Fields ◽  
Elliptic Approximation ◽  
Maximal Suppression

scholarly journals Parathyroid Hormone in Pregnancy: Vitamin D and Other Determinants

Nutrients ◽  
2021 ◽  
Vol 13 (2) ◽  
pp. 360
Author(s):  
Ola Hysaj ◽  
Patricia Marqués-Gallego ◽  
Aline Richard ◽  
Magdeldin Elgizouli ◽  
Alexandra Nieters ◽  
...  
Keyword(s):  
Vitamin D ◽  
Parathyroid Hormone ◽  
Inflection Point ◽  
Demographic Data ◽  
Late Pregnancy ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
25 Hydroxy Vitamin D ◽  
Maximal Suppression

We aimed to assess the parathyroid hormone (PTH) concentration in pregnant women at the beginning of pregnancy (1st trimester) and within days before delivery (3rd trimester) and evaluate its determinants. From September 2014 through December 2015 in a cross-sectional study, 204 women in the 1st trimester of pregnancy and 203 women in the 3rd trimester of pregnancy were recruited. Blood samples were collected to measure PTH and circulating 25-hydroxy-vitamin D (25(OH)D) concentrations. Lifestyle and demographic data were collected using a questionnaire. Serum 25(OH)D and PTH were inversely correlated in both early and late pregnancy. Our analyses suggest that in the 3rd trimester of pregnancy, a 25(OH)D level of 18.9 ng/mL (47.3 nmol/L) could serve as an inflection point for the maximal suppression of PTH. Statistically significant determinants of PTH concentrations in multiple regression were 25(OH)D concentrations, season, multiparity and education of the partner (all p < 0.05) in early pregnancy. In late pregnancy, 25(OH)D concentrations and country of origin were statistically significant determinants of PTH concentrations (all p < 0.05). These factors and their effect on PTH appear to be vastly determined by 25(OH)D; however, they might also affect PTH through other mechanisms besides 25(OH)D.

scholarly journals Anisotropic x-ray scattering and orientation fields in cardiac tissue cells

2017 ◽  
Vol 19 (1) ◽  
pp. 013012 ◽  
Author(s):  
M Bernhardt ◽  
J-D Nicolas ◽  
M Eckermann ◽  
B Eltzner ◽  
F Rehfeldt ◽  
...  
Keyword(s):  
Cardiac Tissue ◽  
X Ray ◽  
X Ray Scattering ◽  
Orientation Fields ◽  
Tissue Cells ◽  
Ray Scattering

Regulation of free fatty acid metabolism by insulin in humans: role of lipolysis and reesterification

2006 ◽  
Vol 263 (6) ◽  
pp. E1063-E1069 ◽  
Author(s):  
P. J. Campbell ◽  
M. G. Carlson ◽  
J. O. Hill ◽  
N. Nurjhan
Keyword(s):  
Fatty Acid ◽  
Free Fatty Acid ◽  
Acid Metabolism ◽  
Insulin Dose ◽  
Healthy Humans ◽  
Constant Rate ◽  
Free Fatty Acid Metabolism ◽  
Plasma Ffa ◽  
Maximal Suppression

The regulation of lipolysis, free fatty acid appearance into plasma (FFA R(a)), an FFA reesterification and oxidation were examined in seven healthy humans infused intravenously with insulin at rates of 4, 8, 25, and 400 mU.m-2.min-1. Glycerol and FFA R(a) were determined by isotope dilution methods, and FFA oxidation was calculated by indirect calorimetry or by measurement of expired 14CO2 from infused [1-14C]palmitate. These measurements were used to calculate total FFA reesterification, primary FFA reesterification occurring within the adipocyte, and secondary reesterification of circulating FFA molecules. Lipolysis, FFA R(a), and secondary FFA reesterification were exquisitely insulin sensitive [the insulin concentrations that produced half-maximal suppression (EC50), 106 +/- 26, 91 +/- 20 vs. 80 +/- 16 pM, P = not significant] in contrast to insulin suppression of FFA oxidation (EC50, 324 +/- 60, all P < 0.01). The absolute rate of primary FFA reesterification was not affected by the increase in insulin concentration, but the proportion of FFA molecules undergoing primary reesterification doubled over the physiological portion of the insulin dose-response curve (from 0.23 +/- 0.06 to 0.44 +/- 0.07, P < 0.05). This served to magnify insulin suppression of FFA R(a) twofold. In conclusion, insulin regulates FFA R(a) by inhibition of lipolysis while maintaining a constant rate of primary FFA reesterification.

Cholecystokinin reduces body temperature in vehicle- but not capsaicin-pretreated rats

1992 ◽  
Vol 263 (6) ◽  
pp. R1215-R1221 ◽  
Author(s):  
E. H. South
Keyword(s):  
Food Intake ◽  
Body Temperature ◽  
Ambient Temperature ◽  
Rectal Temperature ◽  
Neural Substrates ◽  
Systemic Administration ◽  
Capsaicin Application ◽  
Presence And Absence ◽  
Sensory Fibers ◽  
Maximal Suppression

Systemic administration of cholecystokinin C-terminal octapeptide (CCK-8) decreases body temperature. However, it remains unclear whether reduction of body temperature is concomitant with suppression of food intake at CCK-8 doses that approach physiological levels. We examined rectal temperature after intraperitoneal CCK-8, 4 micrograms/kg, both in the presence and absence of a preferred food. We found that rectal temperature was significantly reduced by CCK-8 in both conditions and that the reduction of temperature coincided with the time of maximal suppression of food intake by CCK-8. In rats pretreated systemically with 25 or 175 mg/kg of the sensory neurotoxin capsaicin, both suppression of food intake and reduction of body temperature were significantly attenuated or abolished. The 25 mg/kg capsaicin treatment did not alter corneal chemosensitivity or the ability of rats to maintain normothermia at elevated ambient temperature, suggesting that capsaicin damage to neural substrates mediating CCK-8-induced reduction of body temperature 1) did not generalize to cephalic or peripheral warm-sensitive structures, and 2) was limited to fine sensory fibers accessible to intraperitoneal capsaicin application.

scholarly journals Pharmacoeconomics and Pharmacodynamic Interactions of Rocuronium and Pancuronium

2013 ◽  
Vol 2013 ◽  
pp. 1-6
Author(s):  
HariSrinivas Shyam Kumar ◽  
Padmaja Durga ◽  
Rama Mohan Pathapati ◽  
Sujith Tumkur Rajashekar ◽  
Pothula Narasimha Reddy ◽  
...  
Keyword(s):  
Relationship Quality ◽  
Neuromuscular Function ◽  
Response Relationship ◽  
Hemodynamic Changes ◽  
Pharmacodynamic Interaction ◽  
Pharmacodynamic Interactions ◽  
The Mean ◽  
Mean Cost ◽  
Maximal Suppression

Background. We evaluated the pharmacodynamic interaction of the combination of pancuronium and Rocuronium by analyzing time-response relationship, quality of intubating conditions, changes in the hemodynamics, and cost effectiveness as compared to individual drugs. Methods. Sixty patients in the ASA-I category received either 10 ml of 0.9 mg/kg rocuronium (R) plus 10 ml of saline or 10 ml of 0.1 mg/kg pancuronium (P) plus 10 ml of saline or a combination (C) of 10 ml of 0.45 mg/kg R plus 10 ml of 0.05 mg/kg P according to randomization list. Neuromuscular function was measured up to maximal suppression of twitch height. Results. The mean times (sec) taken for twitch height to decrease to 50% of baseline in R, P, and C were 36.84 ± 2.54, 74.60 ± 4.94, and 40.81 ± 2.34, respectively. The mean cost of intubation per patient was 316.71 ± 83.61 INR in group R, 52.30 ± 14.94 INR in group P, and 93.33 ± 20.65 INR in group C. Conclusions. The combination of P and R provides rapid and smooth intubation with minimal hemodynamic changes at a reasonably priced cost.

Investigation of Parameter Spaces for Topology Optimization With Three-Dimensional Orientation Fields for Multi-Axis Additive Manufacturing

2020 ◽  
Vol 143 (5) ◽  
Author(s):  
Joseph R. Kubalak ◽  
Alfred L. Wicks ◽  
Christopher B. Williams
Keyword(s):  
Topology Optimization ◽  
Additive Manufacturing ◽  
Design Space ◽  
Mechanical Performance ◽  
Unit Length ◽  
Three Dimensions ◽  
Layer By Layer ◽  
Material Distribution ◽  
Orientation Fields ◽  
Material Orientation

Abstract The layer-by-layer deposition process used in material extrusion (ME) additive manufacturing results in inter- and intra-layer bonds that reduce the mechanical performance of printed parts. Multi-axis (MA) ME techniques have shown potential for mitigating this issue by enabling tailored deposition directions based on loading conditions in three dimensions (3D). Planning deposition paths leveraging this capability remains a challenge, as an intelligent method for assigning these directions does not exist. Existing literature has introduced topology optimization (TO) methods that assign material orientations to discrete regions of a part by simultaneously optimizing material distribution and orientation. These methods are insufficient for MA–ME, as the process offers additional freedom in varying material orientation that is not accounted for in the orientation parameterizations used in those methods. Additionally, optimizing orientation design spaces is challenging due to their non-convexity, and this issue is amplified with increased flexibility; the chosen orientation parameterization heavily impacts the algorithm’s performance. Therefore, the authors (i) present a TO method to simultaneously optimize material distribution and orientation with considerations for 3D material orientation variation and (ii) establish a suitable parameterization of the orientation design space. Three parameterizations are explored in this work: Euler angles, explicit quaternions, and natural quaternions. The parameterizations are compared using two benchmark minimum compliance problems, a 2.5D Messerschmitt–Bölkow–Blohm beam and a 3D Wheel, and a multi-loaded structure undergoing (i) pure tension and (ii) three-point bending. For the Wheel, the presented algorithm demonstrated a 38% improvement in compliance over an algorithm that only allowed planar orientation variation. Additionally, natural quaternions maintain the well-shaped design space of explicit quaternions without the need for unit length constraints, which lowers computational costs. Finally, the authors present a path toward integrating optimized geometries and material orientation fields resulting from the presented algorithm with MA–ME processes.

scholarly journals Orientation Fields Filtering by Derivates of a Gaussian

2003 ◽  
pp. 19-27
Author(s):  
Josef Bigun ◽  
Tomas Bigun ◽  
Kenneth Nilsson
Keyword(s):  
Orientation Fields
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