scholarly journals Effect of Cnidoscolus aconitifolius (Family Euphorbiaceae) Aqueous Leaf Extract on Some Antioxidant Enzymes and Haematological Parameters of High Fat Diet and Streptozotocin Induced Diabetic Wistar Albino Rats

2015 ◽  
Vol 19 (2) ◽  
pp. 201 ◽  
Author(s):  
EA Obichi ◽  
CC Monago ◽  
DC Belonwu
Keyword(s):  
Antioxidant Enzymes ◽  
High Fat Diet ◽  
Leaf Extract ◽  
Haematological Parameters ◽  
Albino Rats ◽  
High Fat ◽  
Cnidoscolus Aconitifolius ◽  
Aqueous Leaf Extract ◽  
Wistar Albino Rats

scholarly journals Fetal programming by high-fat diet promoted the decreased of the prostate in adult Wistar albino rats

2020 ◽  
Vol 164 ◽  
pp. 103649
Author(s):  
Pamella Campos-Silva ◽  
Angelo Fernandes ◽  
Waldemar Costa ◽  
Francisco Jose Sampaio ◽  
Bianca Gregorio
Keyword(s):  
Fetal Programming ◽  
High Fat Diet ◽  
Albino Rats ◽  
High Fat ◽  
Wistar Albino Rats

scholarly journals Effect of resveratrol on diabetic neuropathy in wistar albino rats

2019 ◽  
Vol 9 (1) ◽  
pp. 16
Author(s):  
Smita Das ◽  
Jayanti Prava Behera ◽  
Y. Rojaramani ◽  
Rashmi Ranjan Mohanty
Keyword(s):  
Diabetic Neuropathy ◽  
Lipid Profile ◽  
Plasma Glucose ◽  
Fasting Plasma Glucose ◽  
High Fat Diet ◽  
Albino Rats ◽  
High Fat ◽  
Multiple Comparison Test ◽  
Wistar Albino Rats

Background: Type 2 diabetes mellitus (DM) is a common chronic disease with increasing prevalence worldwide. Prolonged uncontrolled hyperglycemia, dyslipidemia are major risk factor for its complication like neuropathy. Since there is no definite treatment for diabetic neuropathy, this study aims to evaluate the effect of resveratrol on diabetic neuropathy in high fat diet with low dose streptozotocin induced type-2 DM model in wistar albino rats.Methods: First type 2 diabetic rat model was established. Wistar albino rats, fed with high-fat diet (HFD) rendered diabetic with streptozotocin, were divided into 6 groups, disease control (DC) treated with vehicle, standard control (SC) which received metformin, test groups treated with 5, 10, and 20 mg/kg b.w. of resveratrol and combination of half dose of metformin and resveratrol (10 mg/kg) (TC). A group of six normal animals served as normal control (NC), another six as HFD control. Fasting plasma glucose, lipid profile were measured one week after induction of diabetes. The animals were then treated orally for 2 weeks after which the same parameters were repeated. Behavioral biomarkers for neuropathy are measured in 4 weeks and 6 weeks of treatment. The in-vivo results were analyzed by one way ANOVA followed by Tukey’s multiple comparison test for biochemical parameters and Kruskal Wallis test followed by Dun’s multiple comparison test for behavioral biomarkers.Results: Increase in fasting plasma glucose (FPG), deranged lipid profile, increased neuropathy in DC compared to NC, HFD control while a significant decrease in FBG, improved pain behavior with SC, test groups (p<0.05) as compared to the DC group.Conclusions: Resveratrol prevents diabetic neuropathy.

scholarly journals Pre-treatment effects against the diclofenac-induced toxicity by the aqueous leaf extract of Madhuca longifolia on female Wistar albino rats for 10 and 15 days

2020 ◽  
pp. 132-143
Author(s):  
Jerine Peter Simon ◽  
Sibi Karthik Saravanan ◽  
Jayashree Sathiyaranayanan ◽  
Radhakrishnan Vidya ◽  
Usha Kumari ◽  
...  
Keyword(s):  
Leaf Extract ◽  
Control Group ◽  
Albino Rats ◽  
Histopathological Analysis ◽  
Group I ◽  
Madhuca Longifolia ◽  
Aqueous Leaf Extract ◽  
Pre Treatment ◽  
Wistar Albino Rats ◽  
Enzyme Markers

Diclofenac is used to treat rheumatism disorders, which are associated with the damages of renal, gastric and hepatic organs. Diclofenac is a pharmaceutical drug that is known to induce toxicity on its overdosage and long-term usage. Madhuca longifolia is known to have antioxidant, anti-inflammatory and anti-ulcer activity. It is an evergreen tree that is reported to have many ethnomedicinal uses. The other properties of Madhuca longifolia include anti-diabetic, analgesic and anti-microbial activities. Our study aims to evaluate the pre-treatment activity against the diclofenac-induced toxicity by the Madhuca longifolia aqueous leaf extract in Wistar albino rats for 10 and 15 days. Rats were divided as Group-I: Normal control, Group-II: Diclofenac on the last two days, Group-III and group-IIIa: Diclofenac + Aqueous Leaf Extract of Madhuca longifolia, Group-IV and group-IVb: Diclofenac + Silymarin, Group -V and group-Va: Aqueous Madhuca longifolia leaf extract. After the sacrifice, the rats were studied for antioxidant assay, renal enzyme markers, liver enzyme markers, and histopathological analysis of the kidney, stomach, intestine, and liver. As a result, we could identify that Madhuca longifolia has reduced the toxic changes in rats caused by diclofenac.

The effect of high-fat diet-induced obesity on cardiovascular toxicity in wistar albino rats

2010 ◽  
Vol 30 (9) ◽  
pp. 1313-1321 ◽  
Author(s):  
Uma Bhandari ◽  
Vinay Kumar ◽  
Naresh Khanna ◽  
Bibhu Prasad Panda
Keyword(s):  
Dietary Fat ◽  
High Fat Diet ◽  
Lipid Peroxides ◽  
Apolipoprotein A1 ◽  
Albino Rats ◽  
High Fat ◽  
Diet Induced Obesity ◽  
Healthy Control ◽  
Wistar Albino Rats

The consumption of a high-fat diet (HFD) is considered a risk factor for obesity development. Nonetheless, a causal role of dietary fat has never been documented, because of inadequate animal models. In our study, one group of rats was fed with standard rat diet, while other group of rats fed with high-fat diet for 4 weeks. After 4 weeks of feeding, the hemodynamic parameters in the rats fed with HFD were significantly increased as compared with control rats. Rats fed with HFD had elevated levels of serum lipids, insulin, leptin, glucose and apolipoprotein B. Lipid peroxides and caspase-3 levels were increased while serum apolipoprotein A1 and antioxidant enzymes levels in heart tissues were decreased in HFD-induced obesity in rats as compared to normal healthy control rats fed on standard rat pellet diet. This model of diet-induced obesity will be a useful tool for studying the mechanisms by which dietary fat induces the obesity in humans.

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