scholarly journals Prevalence and factors associated with Helicobacter pylori infection among treatment naïve dyspeptic adults in University of Benin Teaching Hospital, Benin City, Nigeria

2020 ◽  
Vol 21 (2) ◽  
pp. 97-105
Author(s):  
A.O. Odigie ◽  
A.J. Adewole ◽  
A.A. Ekunwe
Keyword(s):  
Helicobacter Pylori ◽  
Teaching Hospital ◽  
Antigen Test ◽  
Cross Sectional ◽  
Stool Antigen Test ◽  
Factors Associated ◽  
Benin City ◽  
Treatment Naïve ◽  
Stool Antigen ◽  
H Pylori

Background: Infectious diseases such as malaria, HIV/AIDS and  tuberculosis have received tremendous attention globally but inspite of the widespread nature of infections caused by Helicobacter pylori, little attention has been paid to it especially in the developing countries. The objective of this study was to determine the prevalence of and factors associated with H. pylori infection among dyspeptic patients attending the University of Benin Teaching Hospital, Benin City, Nigeria. Methodology: This was a hospital based descriptive cross-sectional study of 354 treatment naive dyspeptic patients aged 18 to 44 years, recruited consecutively after obtaining institutional ethical approval and subjects’ informed consent. A pre-tested interviewer administered questionnaire was used to obtain subjects’ data. The stool antigen test was used to detect H. pylori infection. Results: The prevalence of H. pylori infection among the subject  participants was 34.2% (38.4% in female, 24.0% in male, p=0.009). The age group < 20 years had the highest prevalence of 40%. Gender,  occupation, increased body mass index, high number of household  occupants, and rural dwelling, were significantly associated with H. pylori infection (p<0.05) and alcohol intake was inversely related to H. pylori infection (p<0.05). Conclusion: The prevalence of H. pylori infection in University of Benin Teaching Hospital is high and factors such as gender, obesity, occupation with risk of contact, low socio-economic status, and poor hygiene, may be responsible for this.Keywords: Dyspepsia, Helicobacter pylori, infection, stool antigen test

scholarly journals Noninvasive diagnosis of Helicobacter pylori among patients with dyspepsia

2020 ◽  
Vol 5 (1) ◽  
pp. 28-34
Author(s):  
Suresh Thapa ◽  
Jiwan Thapa ◽  
Binod Karki ◽  
Dibas Khadka ◽  
Anju Bhandari Thapa
Keyword(s):  
Helicobacter Pylori ◽  
Common Disease ◽  
Antigen Test ◽  
Cross Sectional ◽  
Stool Antigen Test ◽  
Resource Limited ◽  
Gastric Biopsies ◽  
Stool Antigen ◽  
H Pylori ◽  
Good Diagnostic Accuracy

Introduction: Helicobacter pylori (H. pylori) infection is a common disease with disparity in geography, age, race and socioeconomic status. Present study aims to assess the accuracy of noninvasive diagnostic tests. Methods: This is a hospital based cross sectional, observational study of 100 dyspeptic patients during November 2017- June 2018. Profile of dyspeptic patients were recorded in a proforma and accuracy of serology and stool antigen test for H. pylori was compared with histology detection in gastric biopsies. Results: Mean age of patients was 39.5±13.7 years with almost equal gender distribution. Prevalence of H. pylori was 56% with dyspeptic symptoms in gastric biopsies. Significant association of the infection was seen in patients with a longer duration of dyspepsia, pangastritis on endoscopy and chronic gastritis on histologic examination. Stool antigen test had good sensitivity (71%) and specificity (82%) for H. pylori detection compared with standard histological diagnosis. Conclusion: Overall prevalence of H. pylori was 56% and was more common in patients of age > 44 years with dyspepsia. Stool antigen has a good diagnostic accuracy and can be used in resource limited settings. However, we recommend a community based study in larger population.

scholarly journals Investigating the Efficacy of Triple Drug Therapy and Sequential Drug Therapy in the Eradication of Helicobacter Pylori with Respect to Antigen Stool test: A Pilot Study

2020 ◽  
Vol 18 (1) ◽  
pp. 74-83
Author(s):  
R. Shrestha ◽  
R. Poudel ◽  
S. Shakya ◽  
R.B. Gurung ◽  
R. Makaju ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Drug Therapy ◽  
Sequential Therapy ◽  
Drug Regimen ◽  
Epidemiological Studies ◽  
Response To Treatment ◽  
Antigen Test ◽  
Stool Antigen Test ◽  
Stool Antigen ◽  
H Pylori

Background Helicobacter pylori is one of the most prevalent infectious disease worldwide. The treatment regimens involve mainly two therapies: Standard Triple drug therapy and Sequential drug therapy. Several studies have shown that the sequential therapy has higher eradication rates of H. pylori than the standard triple drug therapy and since proper study on sequential drug therapy and standard triple drug therapy is still lacking in Nepal, this study is attempted to compare efficacy of Sequential Drug Therapy in the eradication of H. pylori in gastritis with respect to the Standard triple drug therapy. Objective To investigate the efficacy of Triple Drug Therapy and Sequential Drug Therapy in the eradication of Helicobacter pylori with respect to Antigen Stool test. Method This study was the prospective study conducted in 62 patients attending the Department of Gastroenterology, Dhulikhel Hospital, meeting the inclusion criteria who were confirmed as H. pylori positive by histopathology and stool antigen test. Patients were randomized into two groups. One group prescribed with Standard triple drug regimen and another group with Sequential drug regimen. Eradication of H. pylori infection was confirmed by repeating the stool antigen test at least five weeks after the completion of the regimen. Result Among the 62 participants included in this study, 54.5% of them were males. Among the study population, the eradication achieved by standard triple drug therapy was 87.8% and 89.6% with Sequential drug therapy. Higher numbers (82.3%) of patients were compliant to the prescribed medication. Forgetfulness was the main reason for missing the dose (91%) of the non-compliant patients. Conclusion The study revealed an equal efficacy of both Standard Triple drug regimen and Sequential drug regimen in the eradication of H. pylori infection. Further, Stool antigen test can be preferred as a non-invasive test, for diagnosis of H. pylori infection, monitoring the response to treatment and in epidemiological studies.

scholarly journals Evaluation of a stool antigen test using a mAb for native catalase for diagnosis of Helicobacter pylori infection in children and adults

2014 ◽  
Vol 63 (12) ◽  
pp. 1621-1625 ◽  
Author(s):  
Masumi Okuda ◽  
Takako Osaki ◽  
Shogo Kikuchi ◽  
Junko Ueda ◽  
Yingsong Lin ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Real Time ◽  
Real Time Pcr ◽  
High Specificity ◽  
Antigen Test ◽  
Stool Antigen Test ◽  
Non Invasive ◽  
Significant Difference ◽  
Stool Antigen ◽  
H Pylori

Non-invasive diagnosis of Helicobacter pylori infection is important not only for screening of infection but also for epidemiological studies. Stool antigen tests are non-invasive and are convenient to identify H. pylori infection, particularly in children. We evaluated the stool antigen test, which uses a mAb for native catalase of H. pylori developed in Japan. A total of 151 stool samples were collected from participants (52 children and 99 adults) of the Sasayama Cohort Study and stored between −30 and −80 °C. The stool antigen test used was Testmate pylori antigen (TPAg), and was performed according to the manufacturer’s instructions. Furthermore, we conducted a quantitative real-time PCR test and compared the PCR results with those of the TPAg test. When compared with the results in real-time PCR, the sensitivity of TPAg was 89.5 % overall, 82.7 % for children and 92.4 % for adults, and the specificity was 100 %. The accuracy was 93.4 % overall, 90.4 % for children and 94.9 % for adults, and there was no significant difference in the accuracy of TPAg between children and adults. Five of 28 children (18 %) and five of 38 adults (13 %) were PCR positive with negative TPAg results. Four of five children with positive PCR and negative TPAg results were given a 13C-urea breath test and all four children tested negative. No significant correlation was observed between the TPAg results and DNA numbers of H. pylori in faeces among children or adults. A stool antigen test (TPAg) using a mAb for native catalase is useful for diagnosis of H. pylori in children and adults. Additionally, this test has particularly high specificity.

scholarly journals Validation of a rapid stool antigen test for diagnosis of Helicobacter pylori infection

2010 ◽  
Vol 52 (3) ◽  
pp. 125-128 ◽  
Author(s):  
Joyce Matie Kinoshita da Silva ◽  
Cibele Aparecida Villares ◽  
Maria do Socorro Monteiro ◽  
Carlos Colaúto ◽  
Anibal Ferreira dos Santos ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Breath Test ◽  
False Negative ◽  
Lateral Flow ◽  
Antigen Test ◽  
Kappa Index ◽  
Stool Antigen Test ◽  
Infection Diagnosis ◽  
Stool Antigen ◽  
H Pylori

The aim of this study was to validate the rapid lateral flow Helicobacter pylori stool antigen test (One step H. pylori antigen test, ACON laboratories, San Diego, USA; Prime diagnostics, São Paulo), using 13C-Urea Breath Test as the gold standard for H. pylori infection diagnosis. A total of 98 consecutive patients, asymptomatic or dyspeptic, entered the study. Sixty-nine were women, with a mean age of 45.76 ± 14.59 years (14 to 79 years). In the H. pylori-positive group, the rapid stool antigen test detected H. pylori antigen in 44 of the 50 positive patients (sensitivity 88%; 95% CI: 75.7-95.5%), and six false-negative; and in the H. pylori-negative group 42 presented negative results (specificity 87.5%; 95% CI: 74.7-95.3%), and six false-positive, showing a substantial agreement (Kappa Index = 0.75; p < 0.0001; 95% CI: 0.6-0.9). Forty four of fifty patients that had positive stool antigen were H. pylori-positive, the PPV of the stool antigen test was 88% (95% CI: 75.7-95.5%), and 42 patients with negative stool antigen test were H. pylori-negative, the NPV of the stool antigen test was 87.5% (95% CI: 74.7-95.3%). We conclude that the lateral flow stool antigen test can be used as an alternative to breath test for H. pylori infection diagnosis especially in developing countries.

The accuracy of the Helicobacter pylori stool antigen test in diagnosing H. pylori in treated and untreated patients

2001 ◽  
Vol 13 (4) ◽  
pp. 383-386 ◽  
Author(s):  
Nicolaas L. Arents ◽  
Anton A. van Zwet ◽  
Jacob C. Thijs ◽  
Albertine de Jong ◽  
Marco Oudkerk Pool ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Antigen Test ◽  
Stool Antigen Test ◽  
Stool Antigen ◽  
H Pylori

scholarly journals Helicobacter pylori Infection in Infants and Toddlers in South America: Concordance between [13C]Urea Breath Test and Monoclonal H. pylori Stool Antigen Test

2013 ◽  
Vol 51 (11) ◽  
pp. 3735-3740 ◽  
Author(s):  
Dulciene Maria Magalhães Queiroz ◽  
Mayuko Saito ◽  
Gifone Aguiar Rocha ◽  
Andreia Maria Camargos Rocha ◽  
Fabrício Freire Melo ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
South America ◽  
Breath Test ◽  
Urea Breath Test ◽  
Infants And Toddlers ◽  
Antigen Test ◽  
Stool Antigen Test ◽  
Stool Antigen ◽  
13C Urea Breath Test ◽  
H Pylori

scholarly journals Prevalence of Helicobacter pylori among Patients with Gastrointestinal Tract (GIT) Symptoms: A Retrospective Study at Selected Africa Air Rescue (AAR) Clinics in Kampala, Uganda, from 2015 to 2019

2021 ◽  
Vol 2021 ◽  
pp. 1-10
Author(s):  
Edity Namyalo ◽  
Luke Nyakarahuka ◽  
Matthias Afayoa ◽  
Joel Baziira ◽  
Andrew Tamale ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Cross Sectional Study ◽  
Age Group ◽  
Related Factors ◽  
Cross Sectional ◽  
Stool Antigen Test ◽  
Work Related ◽  
Stool Antigen ◽  
H Pylori ◽  
As Stress

Background. Helicobacter pylori (HP) infection is extremely common worldwide, with almost half of the world’s population infected. In Uganda, no study has been done on the trends of the prevalence of H. pylori infection in the affluent population. Therefore, this retrospective cross-sectional study aimed at determining the trend of H. pylori prevalence among affluent patients presenting with gastrointestinal (GIT) symptoms whose stool samples were tested at selected AAR clinics in Kampala area. Patients were tested for Helicobacter pylori infection using the stool antigen test between January 2015 and December 2019. Results. The overall 5-year H. pylori prevalence was 35.7% (1298/3634). The prevalence was higher in males (36.0% (736/2044)) than in females (35.4% (562/1590)), although not statistically significant (OR = 0.97, p = 0.680, 95% CI: 0.84–1.11). The prevalence of H. pylori infection was significantly higher (39.4%) among patients who belonged to the age group of 19–35 years (OR = 1.49, p < 0.001 , 95% CI: 1.22–1.82). The prevalence for H. pylori among the age group of 19–35, the most productive age, could be attributed to work-related factors such as stress. The highest prevalence (43.4%) was recorded in 2018 and the lowest (21.4%) in 2015; however, the trend of H. pylori infection in the 5 years was fluctuating. Conclusion. H. pylori infestation is a preserve of not only the poor but also the elites. Stressful factors, especially in the age group of 19–35 years, should be appropriately managed.

The accuracy of the Helicobacter pylori stool antigen test in diagnosing H. pylori in treated patients

2002 ◽  
Vol 14 (1) ◽  
pp. 89-90 ◽  
Author(s):  
Nicolaas L. Arents ◽  
Anton A. van Zwet ◽  
Jacob C. Thijs ◽  
Albertine de Jong ◽  
Marco Oudkerk Pool ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Antigen Test ◽  
Stool Antigen Test ◽  
Stool Antigen ◽  
H Pylori

scholarly journals Evaluation of [13C]Urea Breath Test and Helicobacter pylori Stool Antigen Test for Diagnosis of H. pylori Infection in Children from a Developing Country

2003 ◽  
Vol 41 (7) ◽  
pp. 3334-3335 ◽  
Author(s):  
L. d. C. C. Cardinali ◽  
G. A. Rocha ◽  
A. M. C. Rocha ◽  
S. B. de Moura ◽  
T. de Figueiredo Soares ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Developing Country ◽  
Breath Test ◽  
Urea Breath Test ◽  
Antigen Test ◽  
Stool Antigen Test ◽  
Stool Antigen ◽  
13C Urea Breath Test ◽  
H Pylori
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