scholarly journals Myalgic Encephalomyelitis Case Definitions

2012 ◽  
Vol 1 ◽  
pp. 1-14 ◽  
Author(s):  
Leonard A. Jason ◽  
Dylan Damrongvachiraphan ◽  
Jessica Hunnell ◽  
Lindsey Bartgis ◽  
Abigail Brown ◽  
...  
Keyword(s):  
Myalgic Encephalomyelitis ◽  
Case Definitions

scholarly journals Profile of circulating microRNAs in myalgic encephalomyelitis and their relation to symptom severity, and disease pathophysiology

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Evguenia Nepotchatykh ◽  
Wesam Elremaly ◽  
Iurie Caraus ◽  
Christian Godbout ◽  
Corinne Leveau ◽  
...  
Keyword(s):  
Treatment Options ◽  
Expression Patterns ◽  
Chronic Fatigue ◽  
Microrna Expression ◽  
Myalgic Encephalomyelitis ◽  
Circulating Microrna ◽  
Prevention Measures ◽  
Case Definitions ◽  
Specific Symptom ◽  
Fatigue Syndrome

AbstractMyalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a complex chronic disease, rooted in multi-system dysfunctions characterized by unexplained debilitating fatigue. Post-exertional malaise (PEM), defined as the exacerbation of the patient's symptoms following minimal physical or mental stress, is a hallmark of ME/CFS. While multiple case definitions exist, there is currently no well-established biomarkers or laboratory tests to diagnose ME/CFS. Our study aimed to investigate circulating microRNA expression in severely ill ME/CFS patients before and after an innovative stress challenge that stimulates PEM. Our findings highlight the differential expression of eleven microRNAs associated with a physiological response to PEM. The present study uncovers specific microRNA expression signatures associated with ME/CFS in response to PEM induction and reports microRNA expression patterns associated to specific symptom severities. The identification of distinctive microRNA expression signatures for ME/CFS through a provocation challenge is essential for the elucidation of the ME/CFS pathophysiology, and lead to accurate diagnoses, prevention measures, and effective treatment options.

scholarly journals Case definitions for chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME): a systematic review

BMJ Open ◽  
2014 ◽  
Vol 4 (2) ◽  
pp. e003973 ◽  
Author(s):  
Kjetil Gundro Brurberg ◽  
Marita Sporstøl Fønhus ◽  
Lillebeth Larun ◽  
Signe Flottorp ◽  
Kirsti Malterud
Keyword(s):  
Systematic Review ◽  
Chronic Fatigue Syndrome ◽  
Chronic Fatigue ◽  
Myalgic Encephalomyelitis ◽  
Case Definitions ◽  
Fatigue Syndrome

scholarly journals The Development of a Consistent Europe-Wide Approach to Investigating the Economic Impact of Myalgic Encephalomyelitis (ME/CFS): A Report from the European Network on ME/CFS (EUROMENE)

Healthcare ◽  
2020 ◽  
Vol 8 (2) ◽  
pp. 88 ◽  
Author(s):  
Derek F.H. Pheby ◽  
Diana Araja ◽  
Uldis Berkis ◽  
Elenka Brenna ◽  
John Cullinan ◽  
...  
Keyword(s):  
Economic Impact ◽  
Cost Of Illness ◽  
Economic Burden ◽  
International Comparisons ◽  
Healthcare Systems ◽  
Myalgic Encephalomyelitis ◽  
Economic Evaluations ◽  
Common Symptom ◽  
Case Definitions ◽  
Effective Prevention

We have developed a Europe-wide approach to investigating the economic impact of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS), facilitating acquisition of information on the economic burden of ME/CFS, and international comparisons of economic costs between countries. The economic burden of ME/CFS in Europe appears large, with productivity losses most significant, giving scope for substantial savings through effective prevention and treatment. However, economic studies of ME/CFS, including cost-of-illness analyses and economic evaluations of interventions, are problematic due to different, arbitrary case definitions, and unwillingness of doctors to diagnose it. We therefore lack accurate incidence and prevalence data, with no obvious way to estimate costs incurred by undiagnosed patients. Other problems include, as for other conditions, difficulties estimating direct and indirect costs incurred by healthcare systems, patients and families, and heterogeneous healthcare systems and patterns of economic development across countries. We have made recommendations, including use of the Fukuda (CDC-1994) case definition and Canadian Consensus Criteria (CCC), a pan-European common symptom checklist, and implementation of prevalence-based cost-of-illness studies in different countries using an agreed data list. We recommend using purchasing power parities (PPP) to facilitate international comparisons, and EuroQol-5D as a generic measure of health status and multi-attribute utility instrument to inform future economic evaluations in ME/CFS.

scholarly journals Systematic review of randomized controlled trials for chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME)

2020 ◽  
Vol 18 (1) ◽  
Author(s):  
Do-Young Kim ◽  
Jin-Seok Lee ◽  
Samuel-Young Park ◽  
Soo-Jin Kim ◽  
Chang-Gue Son
Keyword(s):  
Systematic Review ◽  
Chronic Fatigue Syndrome ◽  
Randomized Controlled Trials ◽  
Chronic Fatigue ◽  
Myalgic Encephalomyelitis ◽  
Controlled Trials ◽  
Pharmacological Interventions ◽  
Case Definitions ◽  
Randomized Controlled ◽  
Fatigue Syndrome

Abstract Background Although medical requirements are urgent, no effective intervention has been proven for chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME). To facilitate the development of new therapeutics, we systematically reviewed the randomized controlled trials (RCTs) for CFS/ME to date. Methods RCTs targeting CFS/ME were surveyed using two electronic databases, PubMed and the Cochrane library, through April 2019. We included only RCTs that targeted fatigue-related symptoms, and we analyzed the data in terms of the characteristics of the participants, case definitions, primary measurements, and interventions with overall outcomes. Results Among 513 potentially relevant articles, 56 RCTs met our inclusion criteria; these included 25 RCTs of 22 different pharmacological interventions, 29 RCTs of 19 non-pharmacological interventions and 2 RCTs of combined interventions. These studies accounted for a total of 6956 participants (1713 males and 5243 females, 6499 adults and 457 adolescents). CDC 1994 (Fukuda) criteria were mostly used for case definitions (42 RCTs, 75.0%), and the primary measurement tools included the Checklist Individual Strength (CIS, 35.7%) and the 36-item Short Form health survey (SF-36, 32.1%). Eight interventions showed statistical significance: 3 pharmacological (Staphypan Berna, Poly(I):poly(C12U) and CoQ10 + NADH) and 5 non-pharmacological therapies (cognitive-behavior-therapy-related treatments, graded-exercise-related therapies, rehabilitation, acupuncture and abdominal tuina). However, there was no definitely effective intervention with coherence and reproducibility. Conclusions This systematic review integrates the comprehensive features of previous RCTs for CFS/ME and reflects on their limitations and perspectives in the process of developing new interventions.

scholarly journals Contrasting Case Definitions for Chronic Fatigue Syndrome, Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and Myalgic Encephalomyelitis

2011 ◽  
Vol 35 (3) ◽  
pp. 280-304 ◽  
Author(s):  
Leonard A. Jason ◽  
Abigail Brown ◽  
Erin Clyne ◽  
Lindsey Bartgis ◽  
Meredyth Evans ◽  
...  
Keyword(s):  
Chronic Fatigue Syndrome ◽  
Chronic Fatigue ◽  
Myalgic Encephalomyelitis ◽  
Case Definitions ◽  
Fatigue Syndrome
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