scholarly journals Antibiotic Susceptibilities of Pseudomonas aeruginosa, Klebsiella pneumoniae and Acinetobacter baumannii Strains Isolated from Patients in the Pediatric Intensive Care Unit

2018 ◽  
Vol 16 (3) ◽  
pp. 109-114 ◽  
Author(s):  
Adem Dursun ◽  
Serkan Özsoylu ◽  
Hüseyin Kılıç ◽  
Ayşegül Ulu Kılıç ◽  
Başak Nur Akyıldız
Keyword(s):  
Intensive Care Unit ◽  
Pseudomonas Aeruginosa ◽  
Intensive Care ◽  
Klebsiella Pneumoniae ◽  
Acinetobacter Baumannii ◽  
Pediatric Intensive Care Unit ◽  
Pediatric Intensive Care ◽  
Antibiotic Susceptibilities

Acquisition of imipenem-resistant Acinetobacter baumannii in a pediatric intensive care unit: a case-control study

2006 ◽  
Vol 32 (9) ◽  
pp. 1384-1391 ◽  
Author(s):  
Aspasia Katragkou ◽  
Maria Kotsiou ◽  
Charalampos Antachopoulos ◽  
Alexis Benos ◽  
Danai Sofianou ◽  
...  
Keyword(s):  
Intensive Care Unit ◽  
Intensive Care ◽  
Acinetobacter Baumannii ◽  
Pediatric Intensive Care Unit ◽  
Case Control Study ◽  
Pediatric Intensive Care ◽  
Case Control ◽  
Control Study

scholarly journals Pola Kuman dan Uji Kepekaan Antibiotik pada Pasien Unit Perawatan Intensif Anak RSMH Palembang

Sari Pediatri ◽  
2016 ◽  
Vol 12 (1) ◽  
pp. 1
Author(s):  
Afriyan Wahyudhi ◽  
Silvia Triratna
Keyword(s):  
Intensive Care Unit ◽  
Intensive Care ◽  
Klebsiella Pneumoniae ◽  
Pediatric Intensive Care Unit ◽  
Pediatric Intensive Care ◽  
Acinetobacter Calcoaceticus ◽  
Staphylococcus Spp

Latar belakang. Unit perawatan intensif anak atau Pediatric Intensive Care Unit (PICU) termasuk unit denganbanyak pemakaian antibiotik. Pemilihan awal antibiotik secara empiris, selanjutnya memerlukan data jeniskuman serta resistensinya terhadap antibiotik. Pemakaian antibiotik yang tidak tepat akan mengakibatkanresistensi kuman dan memperburuk kondisi pasien kritis.Tujuan. Mengetahui pola kuman dan uji kepekaan pasien baru yang dirawat di Unit Perawatan Intensifsebagai salah satu dasar untuk menentukan terapi empiris.Metode. Studi deskriptif pada serial kasus pasien yang dirawat di Unit Perawatan Intensif (PICU) AnakRSMH/FK UNSRI Palembang sejak April 2009 sampai dengan September 2009. Data dianalisis secaradeskriptif dengan tampilan frekuensi dan persentase menggunakan program SPSS 15.0.Hasil. Subjek penelitian 69 orang berusia antara 1 bulan sampai 15 tahun, 58% laki-laki dan 42%perempuan. Ditemukan 75,4% pasien baru terdapat kuman dalam spesimen cairan tubuhnya. Infeksiterbanyak adalah bronkopneumonia (21%). Saluran napas merupakan lokasi terbanyak terdapat bakteri(93,9%), diikuti dengan darah (33,3%), terakhir adalah urin (29%). Bakteri terbanyak yang ditemukan daripemeriksaan biakan adalah Staphylococcus spp. (22,97%), Acinetobacter calcoaceticus (21,62%), Pseudomonasaeruginosa (13,51%), Klebsiella pneumoniae (12,16%), Streptococcus spp. (9,45%), dan sisanya 20,56%mikroorganisme lain. Imipenem dan amikacin masih memiliki sensitifitas yang tinggi terhadap seluruhbakteri yang ditemukan. Antibiotik seperti ceftriaxon, ampicillin, dan gentamicin menunjukkan resistensiyang cukup tinggi. Vancomicin memiliki efektifitas yang sangat baik dan memiliki sensitifitas 100% untuksemua sampel yang diuji.Kesimpulan. Bakteri terbanyak yang ditemukan adalah Staphylococcus, sedangkan imipenem, amikacin,dan vancomicin memiliki sensitifitas yang tinggi terhadap seluruh bakteri yang ditemukan.

scholarly journals 581. The Epidemiology of Imipenem-Resistant Acinetobacter baumannii Bacteremia in a Pediatric Intensive Care Unit and Carbapenem Use

2019 ◽  
Vol 6 (Supplement_2) ◽  
pp. S274-S275
Author(s):  
Dongsub Kim ◽  
Haejeong Lee ◽  
Christina M Croney ◽  
Ki Sup Park ◽  
Hyo Jung Park ◽  
...  
Keyword(s):  
Intensive Care Unit ◽  
Intensive Care ◽  
Infection Control ◽  
Acinetobacter Baumannii ◽  
Pediatric Intensive Care Unit ◽  
Antimicrobial Stewardship ◽  
Pediatric Intensive Care ◽  
Tertiary Teaching ◽  
Antimicrobial Resistance Genes ◽  
Days Of Therapy

Abstract Background Acinetobacter baumannii (AB) infections cause high mortality and morbidity in intensive care unit patients. There are limited data on the epidemiology of imipenem-resistant A. baumannii (IRAB) amongst pediatric ICU patients. Methods A retrospective chart review was performed in patients with AB bacteremia in a pediatric intensive care unit at a tertiary teaching hospital from January 2000 to December 2016. Antimicrobial susceptibility tests, multilocus sequence typing (MLST) and PCR for antimicrobial resistance genes were performed for stored isolates. In addition, antibiotic prescription days of therapy (DOT per 1,000 patient-days) of the pediatric department from January 2001 to December 2016 was analyzed. Results Bacteremia episodes occurred in 27 patients. Male patients were 11 (41%) and the median age at the onset of bacteremia was 5.2 years (range, 0–18.6 years). There was a clear shift in antibiogram of AB during the study period. From 2000 to 2003, all isolates were imipenem-sensitive (ISAB, N = 6). From 2005 to 2008, both IRAB (N = 5) and ISAB (N = 4) were isolated. However, since 2009, all the AB isolates were IRAB (N = 12). In 33% (9/27) of patients, first AB was isolated from tracheal aspirate and patients developed bacteremia later (median duration from AB positive tracheal culture to AB positive blood culture, 8 days [range 5–124]). The overall mortality of patients with AB bacteremia was 59.3% (16/27) within 28 days. There was no statistical difference in mortality between ISAB and IRAB groups (50% vs. 71%; P = 0.42). From MLST analysis of 10 available isolates, sequence type 138 was predominant (N = 7). All 10 isolates were positive for OXA-23-like and OXA-51-like carbapenemase. In 2001, carbapenem DOT per 1,000 patient-days was 15.3 and later strikingly raised to 82.5 in 2009 when all the isolates were imipenem resistant. After this IRAB outbreak in PICU, proactive infection control and antimicrobial stewardship were reinforced among multidisciplinary teams in PICU. IRAB outbreak was terminated and carbapenem DOT per 1,000 patient-days was decreased to 51.7 in 2016. Conclusion IRAB bacteremia causes serious threat in high-risk pediatric patients in PICU. Proactive infection control measures and antimicrobial stewardship are crucial to manage serious IRAB infection in PICU. Disclosures All authors: No reported disclosures.

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