scholarly journals Palmitic Acid-Pluronic F127-Palmitic Acid Penta-Block Copolymer as a Novel Nanocarrier for Oral Delivery of Glipizide

2018 ◽  
Author(s):  
Vipan Kumar Kamboj ◽  
Prabhakar Kumar Verma
Keyword(s):  
Block Copolymer ◽  
Palmitic Acid ◽  
Oral Delivery ◽  
Pluronic F127

Novel l-lactic acid biosensors based on conducting polypyrrole-block copolymer nanoparticles

The Analyst ◽  
2015 ◽  
Vol 140 (3) ◽  
pp. 797-802 ◽  
Author(s):  
Chong Sun ◽  
Daoying Wang ◽  
Muhan Zhang ◽  
Yanxiu Ni ◽  
Xiaohui Shen ◽  
...  
Keyword(s):  
Lactic Acid ◽  
Block Copolymer ◽  
Meat Quality ◽  
Pluronic F127 ◽  
Conducting Polypyrrole

Novel polypyrrole-Pluronic F127 nanoparticles with conducting and biocompatibility properties were used to construct an l-lactic acid biosensor. This method proposes great potential for the detection and evaluation of meat quality.

Binding of Sodium Dodecyl Sulfate (SDS) to the ABA Block Copolymer Pluronic F127 (EO97PO69EO97):  F127 Aggregation Induced by SDS

Langmuir ◽  
2001 ◽  
Vol 17 (1) ◽  
pp. 183-188 ◽  
Author(s):  
Y. Li ◽  
R. Xu ◽  
S. Couderc ◽  
M. Bloor ◽  
E. Wyn-Jones ◽  
...  
Keyword(s):  
Block Copolymer ◽  
Sodium Dodecyl Sulfate ◽  
Sodium Dodecyl ◽  
Pluronic F127 ◽  
Dodecyl Sulfate

Hydrolytic Degradation of Pluronic F127/Poly(lactic acid) Block Copolymer Nanoparticles

2004 ◽  
Vol 37 (9) ◽  
pp. 3425-3430 ◽  
Author(s):  
X. Y. Xiong ◽  
K. C. Tam ◽  
L. H. Gan
Keyword(s):  
Lactic Acid ◽  
Block Copolymer ◽  
Hydrolytic Degradation ◽  
Pluronic F127 ◽  
Poly Lactic Acid

scholarly journals Nanoparticles made of multi-block copolymer of lactic acid and ethylene glycol containing periodic side-chain carboxyl groups for oral delivery of cyclosporine A

2010 ◽  
Vol 7 (suppl_4) ◽  
Author(s):  
D. D. Ankola ◽  
A. Battisti ◽  
R. Solaro ◽  
M. N. V. Ravi Kumar
Keyword(s):  
Molecular Weight ◽  
Particle Size ◽  
Lactic Acid ◽  
Block Copolymer ◽  
Ethylene Glycol ◽  
Cyclosporine A ◽  
Oral Delivery ◽  
Entrapment Efficiency

The purpose of this study was to evaluate the potential of new carboxylated multi-block copolymer of lactic acid and ethylene glycol (EL14) for nanoparticle (NP) formation and their ability to deliver high molecular weight hydrophobic drug—cyclosporine A (CsA). CsA-loaded EL14 NPs were compared with traditional poly(lactide-co-glycolide) (PLGA) NPs, both prepared by emulsion–diffusion–evaporation process. On the one hand, the increase in drug payload from 10 to 30 per cent for EL14 NPs showed no difference in particle size, however the entrapment efficiency tends to decrease from 50 to 43 per cent; on the other hand, the more hydrophobic PLGA showed an increasing trend in entrapment efficiency from 20 to 62 per cent with increasing particle size. Over 90 per cent of CsA was released in vitro from both the nanoparticulates; however, the release was much slower in the case of more hydrophobic PLGA. On in vivo evaluation in rats, the NPs made of EL14 showed a higher C max , a faster T max and enhanced tissue levels to that of PLGA that are crucial for CsA's activity and toxicity; however, the overall bioavailability of the nanoparticulates was similar and higher than Neoral. Together these data demonstrate the feasibility of NPs made of low molecular weight, hydrophilic polymer EL14 for efficient delivery of CsA.

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