scholarly journals Adverse Reactions to Radioiodine 131I Therapy of Goiter in West African Tertiary Hospital

2016 ◽  
Vol 25 (3) ◽  
pp. 128-133
Author(s):  
Yetunde A. Onimode ◽  
John E. Ejeh ◽  
Akintunde T. Orunmuyi
Keyword(s):  
Adverse Reactions ◽  
Tertiary Hospital ◽  
West African ◽  
131I Therapy

scholarly journals EVALUATION OF DRUG THERAPY PROBLEMS IN ASTHMA PATIENTS RECEIVING CARE IN TWO HOSPITALS IN SOUTH-EASTERN NIGERIA

2018 ◽  
Vol 10 (2) ◽  
pp. 50
Author(s):  
Kosisochi Chinwendu Amorha ◽  
Anthony Chukwuma Onu ◽  
Chigozie Gloria Anene-okeke ◽  
Chinwe Victoria Ukwe
Keyword(s):  
Drug Therapy ◽  
Adverse Reactions ◽  
Tertiary Hospital ◽  
Medical Centre ◽  
New Drugs ◽  
Inappropriate Drug ◽  
Cross Sectional ◽  
South Eastern ◽  
Asthma Patients ◽  
Drug Therapy Problems

Objective: To evaluate drug therapy problems in asthma patients visiting a secondary and tertiary hospital in South-Eastern Nigeria.Methods: This study was a retrospective, cross-sectional analyses of the medical records of adult asthmatic patients receiving care in two hospitals in Enugu State, within a 15-year period. The Pharmaceutical Network Care Europe (PCNE) tool version 6.2 was used to assess drug therapy problems. The IBM Statistical Product for Services Solution (SPSS) version 20.0 was used for analysis. For all results, P ≤ 0.05 was considered statistically significant.Results: Majority of the patients were below 60 y old (81.2%); female (68.8%) and were on more than two drugs (95.3%). Majority of the identified drug therapy problems (DTPs) were adverse reactions (65.7%). The inappropriate drug combination was the major cause of DTPs (65.6%). Only about 23.4% of the intervention outcomes were known. University of Nigeria Teaching Hospital (UNTH) had more interventions (35.9%) than Medical Centre (8.0%) (χ2 = 6.323; df = 1; **P = 0.012); and more of the outcomes of their interventions known (38.5%) compared to Medical Centre (0.0%) (χ2 = 12.559; df = 1; **P ˂ 0.001).Conclusion: Adverse reactions and inappropriate drug selection were the major identified DTPs and major cause of DTPs, respectively. Most DTPs had no interventions. The documented interventions included stopping of the drugs, change of drugs or dosage, change of instructions for use and starting of new drugs. Most interventions had unknown outcomes. UNTH had more interventions with known outcomes than the University of Nigeria Medical Centre.

scholarly journals Anaphylactic Reactions in the Emergency Department of a Portuguese Tertiary Hospital: Clinical Characterization and Disease Notification

2019 ◽  
Vol 32 (2) ◽  
pp. 91
Author(s):  
Ana Teresa Fróis ◽  
Teresa Cardoso
Keyword(s):  
Emergency Department ◽  
Adverse Reactions ◽  
Tertiary Care ◽  
Tertiary Hospital ◽  
Clinical Approach ◽  
National Guidelines ◽  
Disease Notification ◽  
Health Products ◽  
Mandatory Notification ◽  
Clinical Records

Introduction: Anaphylaxis is significantly underdiagnosed, and the medical community’s knowledge about it is precarious. The aim of this study is to characterize the patient population and the Emergency Department approach of anaphylaxis.Material and Methods: Retrospective study of adult patients attending the Emergency Department of a tertiary care Portuguese hospital, over a year, with anaphylaxis. Data were obtained from each patient’s clinical records and anonymized. A questionnaire evaluating knowledge about the notification of anaphylaxis was applied to Emergency Department physicians.Results: The study included 69 patients. Cutaneous (97%) and respiratory features (80%) were most prevalent; 22% of patients presented with shock or related symptoms. There were no reported biphasic reactions or deaths. The likely allergen was identified in 73%, most commonly food; 12% of reactions were related to a previously known allergen. Epinephrine was administered to 15%. Referral to an Immunoallergologist was done in 36% of patients, and 10% received or already possessed an epinephrine autoinjector. Among six parameters recommended for auditing clinical practice, 70% of cases fulfilled less than half. Only 13% of physicians knew it was mandatory to register all cases in the Portuguese Catalogue of Allergies and Other Adverse Reactions, and only 4% knew how to do it; regarding notification to the National Authority of Medicines and Health Products results were slightly better.Discussion: Many patients with anaphylaxis present to the Emergency Department every year, and their clinical approach is not in agreement with national guidelines. Conclusion: An educational program to increase medical awareness of the national guidelines and mandatory notification of all anaphylactic reactions should be implemented.

scholarly journals Spectrum of urological cases in a West African Tertiary Hospital

2021 ◽  
Vol 20 (1) ◽  
pp. 14
Author(s):  
Isma'ilaArzika Mungadi ◽  
Abdullahi Khalid
Keyword(s):  
Tertiary Hospital ◽  
West African

scholarly journals Local and Systemic Adverse Reactions to mRNA COVID-19 Vaccines Comparing Two Vaccine Types and Occurrence of Previous COVID-19 Infection

Vaccines ◽  
2021 ◽  
Vol 9 (12) ◽  
pp. 1463
Author(s):  
Oleguer Parés-Badell ◽  
Xavier Martínez-Gómez ◽  
Laia Pinós ◽  
Blanca Borras-Bermejo ◽  
Sonia Uriona ◽  
...  
Keyword(s):  
Healthcare Workers ◽  
Online Survey ◽  
Adverse Reactions ◽  
Tertiary Hospital ◽  
Chronic Illnesses ◽  
Cross Sectional ◽  
Medical Leave ◽  
Group 12 ◽  
Vaccine Type ◽  
History Of

The aim of this study was to assess adverse reactions to COVID-19 vaccines, comparing the BNT162b2 or the mRNA-1273 COVID-19 vaccines and the presence and seriousness of a previous COVID-19 infection. We conducted a cross-sectional online survey of vaccinated healthcare workers at a tertiary hospital in Barcelona (Spain). Thirty-eight percent of vaccine recipients responded to the questionnaire. We compared the prevalence of adverse reactions by vaccine type and history of COVID-19 infections. A total of 2373 respondents had received the BNT162b2 vaccine, and 506 the mRNA-1273 vaccine. The prevalence of at least one adverse reaction with doses 1 and 2 was 41% and 70%, respectively, in the BNT162b2 group, and 60% and 92% in the mRNA-1273 group (p < 0.001). The BNT162b2 group reported less prevalence of all adverse reactions. Need for medical leave was significantly more frequent among the mRNA-1273 group (12% versus 4.6% p < 0.001). Interestingly, respondents with a history of allergies or chronic illnesses did not report more adverse reactions. The frequency of adverse reactions with dose 2 was 96% (95% CI 88–100%) for those with a history of COVID-19 related hospitalization, and 86% (95% CI 83–89%) for those with mild or moderate symptomatic COVID-19, significantly higher than for participants with no history of COVID-19 infections (67%, 95% CI 65–69%). Our results could help inform vaccine recipients of the probability of their having adverse reactions to COVID-19 vaccines.

scholarly journals Management of acute sigmoid volvulus in a tertiary hospital north central nigeria: The place of advanced radiodiagnostics

2021 ◽  
Vol 5 (3) ◽  
pp. 19-26
Author(s):  
Edwin Oseni-Momodu ◽  
◽  
Hassan Shehu ◽  
Jaejeok Lee
Keyword(s):  
Physical Examination ◽  
Surgical Management ◽  
Tertiary Hospital ◽  
Sigmoid Volvulus ◽  
West African ◽  
The West ◽  
Presumptive Diagnosis ◽  
North Central ◽  
X Ray ◽  
Advanced Computer

Background: Volvulus involves the twisting of an air-liquid stool-filled thin-walled segment of an intestine around its necessarily narrow mesenterial base, thereby strangulating the blood vessels, which often causes necrosis of this redundant intestinal segment. Intestinal volvulus had always been supposed to be a disease of the blacks from West African and the Bushmen natives of South Africa. The West African subset became the index region. Surgery was the best treatment for the full-blown disease. Conservative methods of management have only just been developed and studied in the Scandinavian countries. Scandinavian early rectosigmoidoscopic reductions of the twisted colonic segment have offered some valuable alternative helps. Methods: We studied the documents of all the 44 patients who had a presumptive diagnosis of acute or subacute colonic volvulus and were admitted to surgical management. Biostatistics, exact history taking of the patients, carefully structured physical examination, and a good digital scout X-ray investigation of the abdomen helped to make a rapid diagnosis. Laparotomies confirmed such a diagnosis. We did not regularly attempt to do recto-sigmoidoscopic untwisting of the volvuli. All had Hartmann’s procedure surgeries with terminal colostomies. Results: Of the 41 patients admitted to surgical management, 31 were males and 10 were females with a ratio of 3:1. The timing of surgery influenced mortalities and morbidities greatly. Conclusion: The diagnosis of acute volvulus was simple. We needed to record the medical history, took the proper physical examination, correctly explained the examination results, and only studied the abdominal X-ray film without resorting to advanced computer tomography.

scholarly journals Cross With Caution: Antibiotic Cross-Reactivity and Co-Reactivity Patterns in Severe Cutaneous Adverse Reactions

2021 ◽  
Vol 12 ◽  
Author(s):  
Grace Thompson ◽  
Andrew McLean-Tooke ◽  
Michaela Lucas
Keyword(s):  
Adverse Reactions ◽  
Case Series ◽  
Tertiary Hospital ◽  
Cross Reactivity ◽  
Beta Lactam ◽  
Beta Lactam Antibiotics ◽  
Lactam Antibiotic ◽  
Practical Algorithm ◽  
Severe Cutaneous Adverse Reactions ◽  
Cutaneous Adverse Reactions

Current understanding of cross-reactivity in severe cutaneous adverse reactions to beta-lactam antibiotics is limited, thereby making recommendations for future prescribing difficult. The underlying immunopathogenesis of these reactions is not completely understood but involves interactions between small molecule drugs, T cells and HLA molecules. Historically, these reactions were considered to be specific to the inciting antibiotic and therefore likely to have minimal cross-reactivity. We assessed patients presenting with non-SJS/TEN severe cutaneous adverse reactions to a tertiary hospital drug allergy clinic. In our case series cross-reactivity or co-reactivity commonly occurred among the beta-lactam antibiotic class, however further research is required to investigate and understand patterns of cross-reactivity. Based on our experience we provide clinicians with a practical algorithm for testing for cross-reactivity in non-SJS/TEN severe cutaneous adverse reactions.

Sign in / Sign up

Export Citation Format

Share Document