scholarly journals Re: Effects of Recurrent Urinary Tract Infections on Graft and Patient Outcomes After Kidney Transplantation

2018 ◽  
Vol 5 (2) ◽  
pp. 127-127
Author(s):  
Yarkın Kamil Yakupoğlu
Keyword(s):  
Kidney Transplantation ◽  
Urinary Tract ◽  
Patient Outcomes ◽  
Urinary Tract Infections ◽  
Recurrent Urinary Tract Infections ◽  
Tract Infections

scholarly journals Effects of recurrent urinary tract infections on graft and patient outcomes after kidney transplantation

2017 ◽  
Vol 32 (10) ◽  
pp. 1758-1766 ◽  
Author(s):  
Nicholas S. Britt ◽  
Jennifer C. Hagopian ◽  
Daniel C. Brennan ◽  
April A. Pottebaum ◽  
Carlos A.Q. Santos ◽  
...  
Keyword(s):  
Kidney Transplantation ◽  
Urinary Tract ◽  
Patient Outcomes ◽  
Urinary Tract Infections ◽  
Recurrent Urinary Tract Infections ◽  
Tract Infections

Vitamin D Status has no Influence on the Incidence of Recurrent Urinary Tract Infections after Kidney Transplantation

2014 ◽  
Vol 12 (2) ◽  
pp. 114-118 ◽  
Author(s):  
Jean Jeanov Filipov ◽  
Borelli Kirilov Zlatkov ◽  
Emil Paskalev Dimitrov ◽  
Dobrin A. Svinarov
Keyword(s):  
Vitamin D ◽  
Kidney Transplantation ◽  
Urinary Tract ◽  
Urinary Tract Infections ◽  
Pleiotropic Effects ◽  
Kidney Transplant Recipients ◽  
Recurrent Utis ◽  
Recurrent Urinary Tract Infections ◽  
Significant Difference ◽  
Tract Infections

AbstractIntroduction.Recurrent urinary tract infections (rUTIs) after kidney transplantation (KT) are associated with significant decrease in graft survival. There is a growing body of evidence for the pleiotropic effects of vitamin D (VD), including immunomodulatory and antibacterial effect. The number of studies on VD’s pleiotropic effects in kidney transplant recipients (KTRs) however is low. The aim of our study was to assess the influence of VD on the incidence of recurrent UTIs after KT.Methods. The KTRs were tested for 25-hydroxyvitamin D (25VD) between 1.05.2012 and 30.11.2012. Patients within 12 months of transplantation, performed parathyroidectomy, concomitant intake of calcineurin inhibittors and mTOR inhibitors, advanced liver disease and VD supplementation were excluded from the study. Recurrent UTIs were defined as more than 3 episodes of active UTI within the last 12 months of testing for 25VD. Statistical analysis was carried out with SPSS version 22.0 and included descriptive statistics, Mann-Whitney U test. Determination of total 25VD was performed by a validated LC-MS/MS method.Results.A total of 275 patients met the above-mentioned criteria (males 182, females 93). The mean 25VD in patients with rUTIs (n=14) was 51.41±25.17 nmol/L, whereas in the group without rUTIs (n=261) the level was 60.35±23.29 nmol/L. After matching the two groups for seasonal factors (sampling for 25VD in July, August, September) and gender 169 patients were selected, and 11 were with rUTIs. No significant difference was detected in the 25VD level in the two groups (53.30±18.37 vs 49.08±21.04 nmol/L), p=0.342.Conclusions.Despite the higher 25VD in the KTRs without rUTIs, the difference between the two groups remained insignificant.

scholarly journals Treatment of recurrent urinary tract infections in a 60-year-old kidney transplant recipient – last-chance antibiotics and phage therapy

2019 ◽  
Author(s):  
Olga Maria Rostkowska ◽  
Ryszard Międzybrodzki ◽  
Dorota Miszewska-Szyszkowska ◽  
Andrzej Górski ◽  
Magdalena Durlik
Keyword(s):  
Kidney Transplantation ◽  
Urinary Tract ◽  
Antimicrobial Resistance ◽  
Kidney Transplant ◽  
Urinary Tract Infections ◽  
Phage Therapy ◽  
Bacteriophage Therapy ◽  
Treatment Methods ◽  
Recurrent Urinary Tract Infections ◽  
Tract Infections

Abstract Background: The article underlines the problem of antimicrobial resistance in transplant departments where wide-spectrum antibiotics must often be used as first line treatment for immunocompromised patients. This applies especially to kidney transplant recipients who suffer from urinary tract infections. Additional means to control infections and support treatment methods are much needed in departments treating transplant patients. Case presentation: This article presents a case of a 60-year-old patient after kidney transplantation repeatedly admitted to the hospital due to recurrent urinary tract infections, including an episode of urosepsis, caused by Klebsiella pneumoniae producing extended-spectrum beta-lactamases (ESBL). Kidney transplantation was performed due to renal insufficiency caused by polycystic kidney disease, without removing of the patient’s own kidneys. As a consequence of numerous episodes of urinary tract infections (12 episodes within 15 months since transplantation), the patient developed chronic infection caused by ESBL-producing K. pneumoniae which showed variable susceptibility to carbapenems and full susceptibility to colistin only. In the meantime, the patient developed accompanying urinary tract infection caused by a vancomycin-resistant Enterococcus faecium and subsequent colonisation of the gastro-intestinal tract by this strain. In an attempt to curb the K. pneumoniae infection, bacteriophage therapy was applied on the experimental basis, coordinated by the Phage Therapy Unit of the Hirszfeld Institute in Wrocław, Poland. Probiotics were also used in an attempt to modify the bacterial gut colonisation. Eventually, the patient fully recovered following nephrectomy of his own left kidney in which cysts were suspected to be the reservoir of bacteria causing recurring infections. In this article we discuss some treatment methods complementary to classic antibiotic therapy, in times when antimicrobial resistance is on the rapid rise. Conclusions: It is necessary to further research methods of decreasing our reliance on antibiotics in view of falling susceptibility to those medicines. Phage therapy or altering patient’s microbiome can give us an edge in tackling infections which today are treated solely with antimicrobials. This would be of great significance to transplant departments.

scholarly journals Treatment of recurrent urinary tract infections in a 60-year-old kidney transplant recipient – last-chance antibiotics and phage therapy

2019 ◽  
Author(s):  
Olga Maria Rostkowska ◽  
Ryszard Międzybrodzki ◽  
Dorota Miszewska-Szyszkowska ◽  
Andrzej Górski ◽  
Magdalena Durlik
Keyword(s):  
Kidney Transplantation ◽  
Urinary Tract ◽  
Antimicrobial Resistance ◽  
Kidney Transplant ◽  
Urinary Tract Infections ◽  
Phage Therapy ◽  
Bacteriophage Therapy ◽  
Treatment Methods ◽  
Recurrent Urinary Tract Infections ◽  
Tract Infections

Abstract Background: The article underlines the problem of antimicrobial resistance in transplant departments where wide-spectrum antibiotics must often be used as first line treatment for immunocompromised patients. This applies especially to kidney transplant recipients who suffer from urinary tract infections. Additional means to control infections and support treatment methods are much needed in departments treating transplant patients. Case presentation: This article presents a case of a 60-year-old patient after kidney transplantation repeatedly admitted to the hospital due to recurrent urinary tract infections, including an episode of urosepsis, caused by Klebsiella pneumoniae producing extended-spectrum beta-lactamases (ESBL). Kidney transplantation was performed due to renal insufficiency caused by polycystic kidney disease, without removing of the patient’s own kidneys. As a consequence of numerous episodes of urinary tract infections (12 episodes within 15 months since transplantation), the patient developed chronic infection caused by ESBL-producing K. pneumoniae which showed variable susceptibility to carbapenems and full susceptibility to colistin only. In the meantime, the patient developed accompanying urinary tract infection caused by a vancomycin-resistant Enterococcus faecium and subsequent colonisation of the gastro-intestinal tract by this strain. In an attempt to curb the K. pneumoniae infection, bacteriophage therapy was applied on the experimental basis, coordinated by the Phage Therapy Unit of the Hirszfeld Institute in Wrocław, Poland. Probiotics were also used in an attempt to modify the bacterial gut colonisation. Eventually, the patient fully recovered following nephrectomy of his own left kidney in which cysts were suspected to be the reservoir of bacteria causing recurring infections. In this article we discuss some treatment methods complementary to classic antibiotic therapy, in times when antimicrobial resistance is on the rapid rise. Conclusions: It is necessary to further research methods of decreasing our reliance on antibiotics in view of falling susceptibility to those medicines. Phage therapy or altering patient’s microbiome can give us an edge in tackling infections which today are treated solely with antimicrobials. This would be of great significance to transplant departments.

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