scholarly journals Preventing Excessive Blood Loss During Percutaneous Nephrolithotomy by Using Tranexamic Acid: A Double Blinded Prospective Randomized Controlled Trial

2017 ◽  
pp. 195-201 ◽  
Author(s):  
Adnan Siddiq ◽  
Salman Khalid ◽  
Hammad Mithani ◽  
Shariq Anis ◽  
Imran Sharif ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Blood Loss ◽  
Tranexamic Acid ◽  
Percutaneous Nephrolithotomy ◽  
Controlled Trial ◽  
Randomized Controlled ◽  
Prospective Randomized Controlled Trial ◽  
Double Blinded ◽  
Excessive Blood Loss

scholarly journals Tranexamic Acid Reduces Blood Loss and Transfusion in Patients Undergoing Total Knee Arthroplasty without Tourniquet: A Prospective Randomized Controlled Trial

2014 ◽  
Vol 8 (1) ◽  
pp. 250-254 ◽  
Author(s):  
Fernando Bidolegui ◽  
Guillermo Arce ◽  
Alfonso Lugones ◽  
Sebastián Pereira ◽  
Gabriel Vindver
Keyword(s):  
Total Knee Arthroplasty ◽  
Randomized Controlled Trial ◽  
Treatment Group ◽  
Blood Loss ◽  
Tranexamic Acid ◽  
Controlled Trial ◽  
Randomized Controlled ◽  
Prospective Randomized Controlled Trial ◽  
Total Knee ◽  
Without Tourniquet

Introduction : Blood loss during and after total knee arthroplasty (TKA) can lead to substantial morbidity and the need for blood transfusions. There are several methods to minimize blood loss and to decrease transfusion rates in patients undergoing TKA. Tranexamic acid is an antifibrinolytic agent with known efficacy for achieving these goals. Currently, many surgeons are performing TKA without the use of tourniquet. Consequently, the aim of the study is to evaluate whether tranexamic acid reduces blood loss during and after TKA without the adjunctive use of above-the-knee tourniquet. Methods : We performed a prospective randomized controlled trial (1:1 fashion) on the use of tranexamic acid versus placebo in 50 patients undergoing TKA (without tourniquet). The treatment group received two (preoperative and postoperative) 15 mg/kg doses. The primary endpoint was blood transfusion rate. We collected data about demographic and procedural characteristics, hemoglobin and hematocrit values, drain blood loss at 24 hours as well as adverse events. Results : There were no transfusions in the treatment group, whereas 32% of the control group required transfusion (p<0.01). The treatment group had higher hematocrit and hemoglobin levels at 24, 48 and 72 hours after surgery (all p<0.01) and lower drain loss at 24hours (363.4±141 vs 626±260ml, p=<0,001). There were no in-hospital or six-month thromboembolic complications. Discussion : A double-dose of tranexamic acid was safe and effective, reducing blood loss and preventing the need of blood transfusion in patients undergoing TKA without above-the-need tourniquet.

Pre-operative tranexemic acid vs. etamsylate in reducing blood loss during elective cesarean section: randomized controlled trial

2020 ◽  
Vol 0 (0) ◽  
Author(s):  
Haitham Torky ◽  
El-Sayed El-Desouky ◽  
Ibrahim Abo-Elmagd ◽  
Attia Mohamed ◽  
Ahmad Abdalhamid ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Side Effects ◽  
Blood Loss ◽  
Cesarean Section ◽  
Tranexamic Acid ◽  
Controlled Trial ◽  
Elective Cesarean Section ◽  
Randomized Controlled ◽  
Elective Cesarean ◽  
Double Blinded

AbstractObjectivesTo investigate whether etamsylate may be an alternative to tranexamic acid in reduction of blood loss during elective cesarean section.MethodsProspective double-blinded multi-center randomized controlled trial involving 180 qualified women equally divided into three groups each containing 60 women received either tranexamic acid, etamsylate or placebo 20 min before elective cesarean section and blood loss was estimated.ResultsMean blood loss, cases needing blood transfusion and cases needing further interventions were significantly lower in tranexamic acid and etamsylate group than placebo group, while mean postoperative hemoglobin and hematocrite were significantly higher in both tranexamic acid and etamsylate as compared to placebo.ConclusionsEtamsylate is an effective second-line therapy (after tranexamic acid) in reducing blood loss during elective cesarean section with low risk of side effects, therefore, it can be an effective alternative to tranexamic acid in cases with contraindications or anticipated to be at high-risk of developing side effects from tranexamic acid.

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