scholarly journals A Novel Mutation in Thyroid Peroxidase Gene Causing Congenital Goitrous Hypothyroidism in a German-Thai Patient

2016 ◽  
Vol 8 (2) ◽  
pp. 241-245 ◽  
Author(s):  
Chutintorn Sriphrapradang ◽  
Yotsapon Thewjitcharoen ◽  
Suwannee Chanprasertyothin ◽  
Soontaree Nakasatien ◽  
Thep Himathongkam ◽  
...  
Keyword(s):  
Novel Mutation ◽  
Thyroid Peroxidase ◽  
Thai Patient ◽  
Peroxidase Gene

Partial iodide organification defect caused by a novel mutation of the thyroid peroxidase gene in three siblings

2003 ◽  
Vol 59 (2) ◽  
pp. 198-206 ◽  
Author(s):  
Tomio Kotani ◽  
Kazumi Umeki ◽  
Jun-ichi Kawano ◽  
Tatsuo Suganuma ◽  
Akira Hishinuma ◽  
...  
Keyword(s):  
Novel Mutation ◽  
Thyroid Peroxidase ◽  
Peroxidase Gene ◽  
Iodide Organification Defect ◽  
Organification Defect

scholarly journals Five novel inactivating mutations in the thyroid peroxidase gene responsible for congenital goiter and iodide organification defect

2003 ◽  
Vol 22 (3) ◽  
pp. 259-259 ◽  
Author(s):  
Carina M. Rivolta ◽  
Sebastián A. Esperante ◽  
Laura Gruñeiro-Papendieck ◽  
Ana Chiesa ◽  
Christian M. Moya ◽  
...  
Keyword(s):  
Thyroid Peroxidase ◽  
Peroxidase Gene ◽  
Congenital Goiter ◽  
Iodide Organification Defect ◽  
Organification Defect ◽  
Inactivating Mutations

Inhibition of human thyroid peroxidase gene expression by interleukin 1

1989 ◽  
Vol 121 (4) ◽  
pp. 465-469 ◽  
Author(s):  
Kiyoto Ashizawa ◽  
Shunichi Yamashita ◽  
Tamami Tobinaga ◽  
Yuji Nagayama ◽  
Hironori Kimura ◽  
...  
Keyword(s):  
Gene Expression ◽  
Interleukin 1 ◽  
Mrna Level ◽  
Inhibitory Effect ◽  
Human Thyroid ◽  
Thyroid Peroxidase ◽  
Hormone Synthesis ◽  
Peroxidase Gene ◽  
Camp Analogue ◽  
Human Thyroid Peroxidase

Abstract. We have already demonstrated the inhibitory effect of interleukin 1 on thyroglobulin gene expression. Recent availability of thyroid peroxidase cDNA has allowed us to investigate the regulation of thyroid peroxidase gene. Therefore, the regulation of thyroid peroxidase mRNA by interleukin 1 in cultured human thyrocytes was investigated. Thyrocytes dispersed from thyroid tissues from patients with Graves' disease were incubated with TSH with or withtout recombinant human interleukin 1. Unstimulated human thyrocytes did not contain any detectable thyroid peroxidase mRNA, however, TSH-stimulated thyrocytes expressed four thyroid peroxidase mRNA transcripts (4.0, 3.2, 2.1 and 1.7 kb, respectively). Both interleukin 1 α and β inhibited TSH-induced thyroid peroxidase mRNA in a dose responsive manner; 103 U/l interleukin l caused maximal suppression of TSH-induced thyroid peroxidase mRNA level to nearly basal levels. Interleukin l also inhibited cAMP analogue 8-bromo-cyclic AMP induced thyroid peroxidase mRNA level. In contrast the γ-actin mRNA hybridization signal was not altered in control or treated cells. These results demonstrate that interleukin 1 directly inhibits TSH-induced thyroid peroxidase gene expression and provide further evidence for a paracrine role of interleukin 1 as a local inhibitor of thyroid hormone synthesis.

scholarly journals CNS Hypomyelination in Rat Terrier Dogs with Congenital Goiter and a Mutation in the Thyroid Peroxidase Gene

2007 ◽  
Vol 44 (1) ◽  
pp. 50-56 ◽  
Author(s):  
R. Pettigrew ◽  
J. C. Fyee ◽  
B. L. Gregory ◽  
D. Lipsitz ◽  
A. DeLahunta ◽  
...  
Keyword(s):  
Thyroid Peroxidase ◽  
Peroxidase Gene ◽  
Congenital Goiter

Thyroid Peroxidase Gene Mutations Causing Congenital Hypothyroidism in Three Turkish Families

2009 ◽  
Vol 22 (11) ◽  
Author(s):  
M.N. Ozbek ◽  
A.B. Uslu ◽  
N. Onenli-Mungan ◽  
B. Yuksel ◽  
J. Pohlenz ◽  
...  
Keyword(s):  
Congenital Hypothyroidism ◽  
Gene Mutations ◽  
Thyroid Peroxidase ◽  
Peroxidase Gene
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