Factors affecting the etiology of intractable pruritus in hospitalized patients without primary skin lesions

2019 ◽  
Vol 0 (0) ◽  
pp. 0-0
Author(s):  
Neslihan Akdoğan ◽  
Pınar İncel Uysal ◽  
Ayşe Öktem ◽  
Erdem Karabulut ◽  
Yıldız Hayran ◽  
...  
2019 ◽  
Vol 20 (3) ◽  
pp. 224-230
Author(s):  
Neslihan Akdoğan ◽  
Pınar İncel Uysal ◽  
Ayşe Öktem ◽  
Erdem Karabulut ◽  
Yıldız Hayran ◽  
...  

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Jun-Le Liu ◽  
Jian-Wen Jin ◽  
Zhong-Meng Lai ◽  
Jie-Bo Wang ◽  
Jian-Sheng Su ◽  
...  

Abstract Background The prognosis of hospitalized patients after emergent endotracheal intubation (ETI) remains poor. Our aim was to evaluate the 30-d hospitalization mortality of subjects undergoing ETI during daytime or off-hours and to analyze the possible risk factors affecting mortality. Methods A single-center retrospective study was performed at a university teaching facility from January 2015 to December 2018. All adult inpatients who received ETI in the general ward were included. Information on patient demographics, vital signs, ICU (Intensive care unit) admission, intubation time (daytime or off-hours), the department in which ETI was performed (surgical ward or medical ward), intubation reasons, and 30-d hospitalization mortality after ETI were obtained from a database. Results Over a four-year period, 558 subjects were analyzed. There were more male than female in both groups (115 [70.1%] vs 275 [69.8%]; P = 0.939). A total of 394 (70.6%) patients received ETI during off-hours. The patients who received ETI during the daytime were older than those who received ETI during off-hours (64.95 ± 17.54 vs 61.55 ± 17.49; P = 0.037). The BMI of patients who received ETI during the daytime was also higher than that of patients who received ETI during off-hours (23.08 ± 3.38 vs 21.97 ± 3.25; P < 0.001). The 30-d mortality after ETI was 66.8% (373), which included 68.0% (268) during off-hours and 64.0% (105) during the daytime (P = 0.361). Multivariate Cox regression analysis found that the significant factors for the risk of death within 30 days included ICU admission (HR 0.312, 0.176–0.554) and the department in which ETI was performed (HR 0.401, 0.247–0.653). Conclusions The 30-d hospitalization mortality after ETI was 66.8%, and off-hours presentation was not significantly associated with mortality. ICU admission and ETI performed in the surgical ward were significant factors for decreasing the risk of death within 30 days. Trial registration This trial was retrospectively registered with the registration number of ChiCTR2000038549.


2019 ◽  
Vol 55 (4) ◽  
pp. 592-599 ◽  
Author(s):  
Nour Fattouh ◽  
Souheil Hallit ◽  
Pascale Salameh ◽  
Georges Choueiry ◽  
Francois Kazour ◽  
...  

2017 ◽  
Vol 152 (5) ◽  
pp. S289-S290
Author(s):  
Nasim Parsa ◽  
Mahya Faghih ◽  
Robert Moran ◽  
Ayesha Kamal ◽  
Niloofar Yahyapourjalaly ◽  
...  

2020 ◽  
Vol 66 (3) ◽  
Author(s):  
Kinga Budzińska ◽  
Marta Kożybska ◽  
Paulina Zabielska ◽  
Anna Knyszyńska ◽  
Joanna Pierzak-Sominka ◽  
...  

Introduction: Psoriasis is a chronic inflammatory and non-infectious skin disease. It is one of the most common dermatoses. Increased reproduction of the epidermis and, as a consequence, visible skin lesions negatively affect the patient's psyche, disrupt self-esteem, reducing the chance of accepting the disease and a normal life.The aim of this study was the assessment of the level of acceptance of the illness and identification of factors affecting its acceptance among patients with psoriasis.Materials and methods: The study involved 132 individuals, comprising 113 women and 19 men. This survey-based study was conducted via the Internet using the author's questionnaire and the Acceptance of Illness Scale (AIS).Results: Acceptance of the illness level was rated great and moderate by respectively 43.9% and 39.4% of respondents. Over 66.7% of the patients described their self-esteem as high obtained a great level of acceptance of the illness according to the AIS. In the examined group, 58% of the patients not accepted psoriatic lesions on their body. Over 60% of the respondents experienced negative reactions from society regarding the disease, and almost 50% of them experienced other people’s reactions resulting from concerns about contracting the disease; these patients obtained lower AIS scores.Conclusions: The obtained results indicate a great illness acceptance among the examined group of the patients with psoriasis. The level of acceptance was influenced by the patient’s self-esteem in relation to the disease, acceptance of their own body image, altered by the disease, experiencing the negative reactions from the society regarding the disease, and the reactions of the other people resulting from concerns about contracting the disease.


2018 ◽  
pp. 096973301875983 ◽  
Author(s):  
Tayebeh Hasan Tehrani ◽  
Sadat Seyed Bagher Maddah ◽  
Masoud Fallahi-Khoshknab ◽  
Abbas Ebadi ◽  
Farahnaz Mohammadi Shahboulaghi ◽  
...  

Background: Privacy is a complicated and obscure concept, which has special meanings in the healthcare environment; therefore, it is essential for healthcare providers to fully understand this concept. However, there is no universally accepted definition for this concept in the texts, and it has been interpreted differently, based on its application. Aim: To analyze and provide a clear and scientific definition for respect of privacy of hospitalized patients and identify the common aspects of this concept. Research design: This study was conducted using the Whittemore and Knafl’s modified framework as a conceptual analysis method. Ethical consideration: This study was approved by the Research Council of the University of Social Welfare and Rehabilitation Sciences. We have respected the ethical requirements required regarding the sources and authorship. Research context and data sources: Using integrative review, a search was performed using national and international databases, including CINAHL, Scopus, Medline, Web of Science, and ISI (with no date restriction). The keywords employed during the search process were “privacy of patients,” “confidentiality,” “and patients’ rights.” In total, 1345 articles were retrieved from the databases. After the elimination of repetitive studies and with regard to the study objectives, 124 articles, 3 books, and 4 theses were entered into the study. The data were analyzed using the conventional content analysis approach. Findings: The results were extracted in the form of four, seven, and two themes related to attributes such as physical, informational, social, and psychological and the antecedents and consequences of respecting patient privacy, respectively. Conclusion: Respect for hospitalized patient privacy contains multiple dimensions. Factors affecting the achievement of this concept include individual backgrounds, nature of the disease, and rule of paternalism. The fulfillment of patient privacy leads to such consequences as protection and improvement of human dignity as well as improved communication between the patient and the health team.


Author(s):  
Parvin Sarbakhsh ◽  
Saba Ghaffary ◽  
Elnaz Shaseb

Abstract Introduction: Considering that covid-19 is an emerging disease and results in very different outcomes-from complete recovery to death, it is important to determine the factors affecting the survival of patients. Given the lack of knowledge about effective factors and the existence of differences in the outcome of individuals with similar values of the observed covariates, this study aimed to investigate the factors affecting the survival of patients with COVID-19 by the parametric survival model with the frailty approach. Methods: The data of 139 patients with COVID-19 hospitalized in Imam Reza Hospital in Tabriz were analyzed by the Gompertz survival model with gamma frailty effect. At first, variables with p-value<.1 in univariable analysis were included in the multivariable analysis, and then the stepwise method was used for variable selection. Results: Diabetes mellitus (p-value =.021) was significantly related to the survival of hospitalized patients. The rest of the investigated variables were not significant. The frailty effect was significant (p-value=.019). Conclusion: In the investigated sample of patients with covid19, diabetes was an important variable related to patient survival. Also, the significant frailty effect indicates the existence of unobserved heterogeneity that cause individuals with a similar value of the observed covariates to have different survival distributions.


2021 ◽  
Author(s):  
Gunadi ◽  
Mohamad Saifudin Hakim ◽  
Hendra Wibawa ◽  
Marcellus ◽  
Ika Trisnawati ◽  
...  

Abstract Background: Recent studies focusing on the association of SARS-CoV-2 variants of concern (VOC) on COVID-19 outcomes have been reported. However, studies of the impact of multiple mutations within the spike (S) protein of SARS-CoV-2 on COVID-19 illness are limited. This study determined the association between multiple mutations within the S protein, prognosis factors, and the disease outcomes of SARS-CoV-2 infection. Methods: We included 51 COVID-19 patients from Yogyakarta and Central Java, Indonesia. Whole genome sequences of SARS-CoV-2 were determined by the Illumina MiSeq next-generation sequencer, followed by the phylogenetic analysis of 170 full-genomes of SARS-CoV-2 from different regions. We analyzed characteristics of COVID-19 patients and multiple mutations in association with different outcomes.Results: Among 51 patients, the clinical manifestations of COVID-19 were as follows: without any symptoms (13.7%), mild (47%), moderate (19.6%), severe (4%), critical (2%), and died (13.7%). The age of hospitalized patients (53.4 ± 18 years) was higher than non-hospitalized patients (34.6 ± 19) (p=0.001). A significant association between diabetes, hypertension, and anticoagulant and the hospitalization of patients was noted with p-value of 0.039 (OR=4.47 [95% CI=1.07-18.58]), 0.001 (OR=17 [95% CI=2-144]), and 0.02 (OR=27.97 [95% CI=1.54-507.13]), respectively; whereas a strong association between patients’ age, diabetes, anticoagulant, and steroid with the mortality of patients was revealed with p-value of 0.016 (OR=8.44 [95% CI=1.5-47.49]), 0.019 (OR=8.5 [95% CI=1.43-50.66]), 0.001 (46.8 [95% CI=4.63-472.77]), and 0.009 (OR=15.75 [95% CI=2-123.86]), respectively. All viruses contained the D614G variant, except one case. Accordingly, the samples were classified as the following clade: L (2%), GH (84.3%), GR (11.7%), and O (2%). Besides the D614G, the most common variants in the S protein were L5F (18.8%), V213A (18.8%), and S689R (8.3%). There was no significant association between multiple S protein variants with either hospitalization or mortality of COVID-19 (p=0.11 and 0.69, respectively). Multivariate analysis showed that hypertension and anticoagulant were the strong factors affecting the hospitalization and mortality of patients with COVID-19 with a p-value of 0.009 (OR=17.06 [95% CI=2.02-144.36]) and 0.001 (OR=46.8 (95% CI=4.63-472.77), respectively. Interestingly, the multiple S protein variants almost reached a significant level affecting the hospitalization of patients (p=0.07). Phylogenetic analysis showed that although most of the viruses from this study belonged to clade GH, none were detected as the variant of concern (VOC) and the variant of interest (VOI) of SARS-CoV-2.Conclusions: Here, we show for the first time the association between SARS-CoV-2 mutations within the S protein besides the VOC with the COVID-19 outcomes. Our findings suggest that multiple mutations in the S protein might affect the severity of COVID-19. Our study further suggests the importance of genomic surveillance to monitor SARS-CoV-2 variants, particularly those that might influence the outcomes of COVID-19 patients.


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