Evaluation of Receptor Activator of Nuclear Factor Kappa-B Ligand and Osteoprotegerin Levels in Patients with Type 2 Diabetes Mellitus Treated with Oral Anti-Diabetic (Sulfonylurea and Metformin) or Insulin from the Perspective of Bone

2019 ◽  
Vol 0 (0) ◽  
pp. 0-0
Author(s):  
Alper Gümüş ◽  
Muhammed Emin Düz ◽  
Cihan Coşkun ◽  
Mustafa Velet ◽  
Macit Koldaş
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Nuclear Factor Kappa B ◽  
Nuclear Factor ◽  
Nuclear Factor Kappa ◽  
Receptor Activator

Polymorphism rs2073618 of the osteoprotegerin gene as a potential marker of subclinical carotid atherosclerosis in Caucasians with type 2 diabetes mellitus

VASA ◽  
2017 ◽  
Vol 46 (5) ◽  
pp. 355-362 ◽  
Author(s):  
Aleš Pleskovič ◽  
Sara Mankoč Ramuš ◽  
Zala Jenko Pražnikar ◽  
Marija Šantl Letonja ◽  
Andreja Cokan Vujkovac ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Carotid Plaque ◽  
Carotid Atherosclerosis ◽  
Nuclear Factor Κb ◽  
Nuclear Factor ◽  
Increased Risk ◽  
Receptor Activator

Abstract. Background: The OPG/RANKL/RANK (osteoprotegerin/receptor-activator of nuclear factor κB ligand/receptor-activator of nuclear factor κB) axis has been recently linked to the development of atherosclerosis and plaque destabilization. We have investigated whether polymorphism rs2073618 of the OPG gene is associated with subclinical markers of carotid atherosclerosis in subjects with type 2 diabetes mellitus (T2DM). Patients and methods: 595 subjects with T2DM were enrolled in the cross-sectional study. Subclinical markers of carotid atherosclerosis (carotid intima media thickness, plaque thickness, and plaques presence) were assessed with ultrasound at the time of recruitment. Genotyping for rs2073618 (a missense variant located in exon I of the OPG gene) was performed, and OPG serum levels were determined by ELISA. Results: Compared to the GG genotype, the CC genotype of the rs2073618 polymorphism had a significantly increased risk for the presence of carotid plaque (OR = 2.54, 95 % CI = 1.22–5.28, p = 0.01). No statistically significant difference could be detected (p = 0.68) upon comparing median values of serum OPG levels among studied genotype groups in subjects with T2DM. Multivariable linear regression analyses in T2DM subjects demonstrated that GC and CC genotypes (p = 0.03 and p = 0.003), together with statin therapy (p = 0.009), were independent predictors of the number of carotid segments with plaques. Conclusions: Despite the fact that OPG rs2073618 genotypes failed to predict the serum OPG levels as there was no statistical difference among compared genotypes, our results demonstrate that the rs2073618 polymorphism could be a possible genetic marker for the prediction of increased risk for carotid plaque burden as a measure of advanced subclinical atherosclerosis in T2DM subjects.

Receptor Activator of Nuclear Factor-Kappa B Ligand/Osteoprotegerin Ratio in Sites of Chronic Periodontitis of Subjects With Poorly and Well-Controlled Type 2 Diabetes

2010 ◽  
Vol 81 (10) ◽  
pp. 1455-1465 ◽  
Author(s):  
Vanessa Renata Santos ◽  
Jadson Almeida Lima ◽  
Tiago Eduardo Dias Gonçalves ◽  
Marta Ferreira Bastos ◽  
Luciene Cristina Figueiredo ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Chronic Periodontitis ◽  
Nuclear Factor Kappa B ◽  
Nuclear Factor ◽  
Nuclear Factor Kappa ◽  
Receptor Activator
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