scholarly journals Efficiency of Hemodiafiltration in Severe Lactic Acidosis Due to Metformin Intoxication: Case Report

2018 ◽  
Vol 5 (1) ◽  
pp. 47-48
Author(s):  
Nihal Akçay ◽  
Mey Talip Petmezci ◽  
Ülkem Koçoğlu Barlas ◽  
Esra Şevketoğlu ◽  
Hasan Serdar Kıhtır
Keyword(s):  
Case Report ◽  
Lactic Acidosis ◽  
Severe Lactic Acidosis

scholarly journals Unexplained Severe Lactic Acidosis in Young Patient.

2019 ◽  
Vol 3 (2) ◽  
Author(s):  
Alfred Ibrahimi ◽  
Saimir Kuci ◽  
Ervin Bejko ◽  
Stavri Llazo ◽  
Maksim Llambro
Keyword(s):  
Case Report ◽  
Metabolic Acidosis ◽  
Lactic Acidosis ◽  
Lactate Concentration ◽  
Blood Lactate Concentration ◽  
Blood Gas ◽  
Type B ◽  
Antidiabetic Drug ◽  
Common Cause ◽  
Severe Lactic Acidosis

Case report: A 27-year-old previously healthy man was admitted to the ICU complaining nausea, vomiting and disorientation, after he ingested 1500 mg paracetamol, but its relatives explained that they possess in the house only metformin (maybe he ingested metformin instead of paracetamol). First blood gas showed moderate, and hours later severe lactic acidosis Ph 7,01, Lac 25 m mol/L, BE -26,4. Aggressive rehydration and hemofiltration was started, until full recovery after 24 hours of hospital admission. He was discharged after three days in healthy condition. Discussion: Lactic acidosis is a common cause of metabolic acidosis at the ICU. Type A is most common and caused by hypoperfusion or hypoxia, whilst type B has other causes including use of the antidiabetic drug metformin. Metformin associated lactic acidosis (MALA) is an important treatment-associated condition, and although rare, it is very serious. Conclusion: MALA should be strongly suspected in patients presenting with wide anion gap metabolic acidosis and high blood lactate concentration. Bicarbonate hemodialysis or continuous renal replacement therapy should be urgently arranged for patients with MALA.

scholarly journals Composite pheochromocytoma presenting as severe lactic acidosis and back pain: A case report

2019 ◽  
Vol 29 (5) ◽  
pp. 353
Author(s):  
S Rajagopalan ◽  
RMathi Manoj Kumar ◽  
NK Narayanan ◽  
KJ Raghunath
Keyword(s):  
Back Pain ◽  
Case Report ◽  
Lactic Acidosis ◽  
Severe Lactic Acidosis ◽  
Composite Pheochromocytoma

scholarly journals SEVERE LACTIC ACIDOSIS WITH ALBUTEROL: A CASE REPORT

CHEST Journal ◽  
2020 ◽  
Vol 158 (4) ◽  
pp. A1860 ◽  
Author(s):  
Rakesh Gami ◽  
James Choi ◽  
Tyler Kemnic ◽  
Jason Liu Liu
Keyword(s):  
Case Report ◽  
Lactic Acidosis ◽  
Severe Lactic Acidosis

scholarly journals Lactic Acidosis in a Congenital Bone Marrow Failure Syndrome

2021 ◽  
pp. 1-4
Author(s):  
Fatima Farid Mir ◽  
Anjan Madasu ◽  
Hani Humad ◽  
Asim Noor Rana
Keyword(s):  
Bone Marrow ◽  
Mitochondrial Dna ◽  
Metabolic Acidosis ◽  
Lactic Acidosis ◽  
Liver Failure ◽  
Bone Marrow Failure ◽  
Disease Course ◽  
Bone Marrow Failure Syndrome ◽  
Severe Lactic Acidosis ◽  
End Stage

Fifteen-month-old male child, known to have a congenital bone marrow failure syndrome, presented in a state of shock with severe lactic acidosis following a brief episode of vomiting. Hospital stay was complicated by recurrent bouts of metabolic acidosis and progressive hepatic failure. Blood mitochondrial DNA sequencing revealed a large heteroplasmic 4,977 bp mitochondrial deletion (approximately 40% of all mitochondrial copies) suggestive of Pearson marrow-pancreas syndrome. By virtue of natural disease course, within a month of admission child succumbed to end-stage liver failure with multi-organ failure and died.

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