BEARING, ROLLER, NEEDLE, TRACK ROLLER INTEGRAL STUD, SEALED, TYPE VIII ANTIFRICTION, INCH

2021 ◽  
Author(s):  
Keyword(s):  
2021 ◽  
Vol 7 (6) ◽  
pp. 419
Author(s):  
Maria Siopi ◽  
Ioanna Efstathiou ◽  
Konstantinos Theodoropoulos ◽  
Spyros Pournaras ◽  
Joseph Meletiadis

Trichophyton isolates with reduced susceptibility to antifungals are now increasingly reported worldwide. We therefore studied the molecular epidemiology and the in vitro antifungal susceptibility patterns of Greek Trichophyton isolates over the last 10 years with the newly released EUCAST reference method for dermatophytes. Literature was reviewed to assess the global burden of antifungal resistance in Trichophyton spp. The in vitro susceptibility of 112 Trichophyton spp. molecularly identified clinical isolates (70 T. rubrum, 24 T. mentagrophytes, 12 T. interdigitale and 6 T. tonsurans) was tested against terbinafine, itraconazole, voriconazole and amorolfine (EUCAST E.DEF 11.0). Isolates were genotyped based on the internal transcribed spacer (ITS) sequences and the target gene squalene epoxidase (SQLE) was sequenced for isolates with reduced susceptibility to terbinafine. All T. rubrum, T. interdigitale and T. tonsurans isolates were classified as wild-type (WT) to all antifungals, whereas 9/24 (37.5%) T. mentagrophytes strains displayed elevated terbinafine MICs (0.25–8 mg/L) but not to azoles and amorolfine. All T. interdigitale isolates belonged to ITS Type II, while T. mentagrophytes isolates belonged to ITS Type III* (n = 11), VIII (n = 9) and VII (n = 4). All non-WT T. mentagrophytes isolates belonged to Indian Genotype VIII and harbored Leu393Ser (n = 5) and Phe397Leu (n = 4) SQLE mutations. Terbinafine resistance rates ranged globally from 0–44% for T. rubrum and 0–76% for T. interdigitale/T. mentagrophytes with strong endemicity. High incidence (37.5%) of terbinafine non-WT T. mentagrophytes isolates (all belonging to ITS Type VIII) without cross-resistance to other antifungals was found for the first time in Greece. This finding must alarm for susceptibility testing of dermatophytes at a local scale particularly in non-responding dermatophytoses.


2006 ◽  
Vol 23 (9) ◽  
pp. 3017-3035 ◽  
Author(s):  
Sigbjørn Hervik ◽  
Woei Chet Lim

2021 ◽  
Vol MA2021-02 (3) ◽  
pp. 405-405
Author(s):  
Andrew Dopilka ◽  
Amanda Childs ◽  
Alexander Ovchinnikov ◽  
Svilen Bobev ◽  
Xihong Peng ◽  
...  

2018 ◽  
Vol 69 (2) ◽  
pp. 185-188 ◽  
Author(s):  
Simona Stolnicu ◽  
Alexandra Giurgi ◽  
Orsolya Bauer ◽  
Anca Chiriac ◽  
Cristian Podoleanu ◽  
...  

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