Release Agent, for Use During Form-in-Place Gasket Preparation

Gum arabic helps prepare better lacey polymer films for specimen support in electron microscopy

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100147041 ◽

1993 ◽

Vol 51 ◽

pp. 240-241

Author(s):

Shailesh R. Sheth ◽

Jayesh R. Bellare

Keyword(s):

Electron Microscopy ◽

Polymer Films ◽

Gum Arabic ◽

Complete Removal ◽

Ammonium Bromide ◽

Release Agent ◽

Astigmatism Correction ◽

Long Time ◽

Micro Holes ◽

Cetyl Trimethyl Ammonium

Specimen support and astigmatism correction in Electron Microscopy are at least two areas in which lacey polymer films find extensive applications. Although their preparation has been studied for a very long time, present techniques still suffer from incomplete release of the film from its substrate and presence of a large number of pseudo holes in the film. Our method ensures complete removal of the entire lacey film from the substrate and fewer pseudo holes by pre-treating the substrate with Gum Arabic, which acts as a film release agent.The method is based on the classical condensation technique for preparing lacey films which is essentially deposition of minute water or ice droplets on the substrate and laying the polymer film over it, so that micro holes are formed corresponding to the droplets. A microscope glass slide (the substrate) is immersed in 2.0% (w/v) aq. CTAB (cetyl trimethyl ammonium bromide)-0.22% (w/v) aq.

Download Full-text

Design of Experiments to Evaluate Use of Chitosan-Tripolyphosphate as a Sustained Release Agent in Directly Compressible Tablets

10.26226/morressier.57d6b2bad462b8028d88dbe9 ◽

2016 ◽

Author(s):

Colin Pinto

Keyword(s):

Design Of Experiments ◽

Sustained Release ◽

Release Agent

Download Full-text

Formulation and Evaluation of Atenolol and Indapamide SR Matrix Tablets for Treatment of Hypertension

International Journal of Pharmaceutical Sciences and Nanotechnology ◽

10.37285/ijpsn.2014.7.2.7 ◽

2014 ◽

Vol 7 (2) ◽

pp. 2450-2458

Author(s):

Sarika Pundir ◽

Ashutosh Badola

Keyword(s):

Kinetic Studies ◽

Film Coating ◽

Matrix Tablets ◽

Wet Granulation ◽

Simultaneous Estimation ◽

Matrix Tablet ◽

Release Agent ◽

Disintegration Time ◽

Weight Variation

In the present study we have formulated (F1 to F6) matrix tablets of atenolol and indapamide for the management of hypertension. As in simultaneous estimation of these drugs it was found that a confined release can be formulated. In the formulation of SR matrix tablet by using different concentration of delayed release agent DCP and pregelatinized starch as disintegrant we prepared tablets by wet granulation method. For sustained release action HPMC polymers were used for film coating. Preformulation studies were performed prior to compression. The compressed SR matrix tablets were evaluated for weight variation, hardness, friability, drug content, disintegration time and in vitro drug release using USP dissolution apparatus type 2 (paddle). It was found that the optimized formulation showed 49.33%, 48.90%, 48.52%, 47.65%, 46.84% and 46.51% release for atenolol in 12 hours respectively. However, indapamide released 49.62%, 49.39%, 48.72%, 48.27%, 47.59% and 47.36% at the end of 12 hr. The IR spectrum study revealed that there is no disturbance in the principal peaks of pure drugs atenolol and indapamide. This confirms the integrity of pure drugs and no incompatibility of them with excipients. The stability studies were carried out for the optimized batch for one months and it showed satisfactory results. The kinetic studies of the formulations revealed that diffusion is the predominant mechanism of drug and release follows Zero-order, Super case II transport.

Download Full-text