Substrate Selection for a Diesel Catalyst

1995 ◽  
Author(s):  
Michael G. Campbell ◽  
Edward P. Martin
Glycobiology ◽  
2021 ◽  
Author(s):  
Hannah M Stephen ◽  
Trevor M Adams ◽  
Lance Wells

Abstract Thousands of nuclear and cytosolic proteins are modified with a single β-N-acetylglucosamine on serine and threonine residues in mammals, a modification termed O-GlcNAc. This modification is essential for normal development and plays important roles in virtually all intracellular processes. Additionally, O-GlcNAc is involved in many disease states, including cancer, diabetes, and X-linked intellectual disability. Given the myriad of functions of the O-GlcNAc modification, it is therefore somewhat surprising that O-GlcNAc cycling is mediated by only two enzymes: the O-GlcNAc transferase (OGT), which adds O-GlcNAc, and the O-GlcNAcase (OGA), which removes it. A significant outstanding question in the O-GlcNAc field is how do only two enzymes mediate such an abundant and dynamic modification. In this review, we explore the current understanding of mechanisms for substrate selection for the O-GlcNAc cycling enzymes. These mechanisms include direct substrate interaction with specific domains of OGT or OGA, selection of interactors via partner proteins, posttranslational modification of OGT or OGA, nutrient sensing, and localization alteration. Altogether, current research paints a picture of an exquisitely regulated and complex system by which OGT and OGA select substrates. We also make recommendations for future work, toward the goal of identifying interaction mechanisms for specific substrates that may be able to be exploited for various research and medical treatment goals.


2015 ◽  
Vol 2 (18) ◽  
pp. 1500423 ◽  
Author(s):  
Silvia Trabattoni ◽  
Luisa Raimondo ◽  
Marcello Campione ◽  
Daniele Braga ◽  
Vincent C. Holmberg ◽  
...  

2015 ◽  
Vol 177 ◽  
pp. 349-356 ◽  
Author(s):  
John R. Casey ◽  
Paul G. Falkowski ◽  
David M. Karl

2013 ◽  
Vol 290 (2) ◽  
pp. 143-150 ◽  
Author(s):  
J. Ruiz-Olmo ◽  
A. Such-Sanz ◽  
C. Piñol

2011 ◽  
Vol 27 (3) ◽  
pp. 433-439 ◽  
Author(s):  
L. B. Moody ◽  
R. T. Burns ◽  
G. Bishop ◽  
S. T. Sell ◽  
R. Spajic

1963 ◽  
Vol 40 (3) ◽  
pp. 447-454
Author(s):  
CLYDE H. ERIKSEN

1. This study is concerned with the relation of oxygen consumption to substrate particle size in the morphologically similar burrowing mafies Ephemera simulansand Hexagenia limbata. 2. Nymphs, 16-24 mm. in length, were placed at 13.0°C. for 24 hr. before experimentation. Oxygen consumption experiments employed the standard ‘oxygen consumed in a closed bottle ’ technique and a modification. The standard technique was referred to as the ‘blank-bottle’ method, while the modification was called the ‘substrate-bottle’ method (washed substrate fractions were placed in the bottle). 3. The relationship between substrate particle size and oxygen consumption was indicated by a bimodal curve. The oxygen consumption fell, rose and fell once more as the particle size decreased from χ - 4 to χ + 5. 4. Substrate selection experiments with E. simulans nymphs revealed an inverse relationship between selection for particle size and oxygen consumption. 5. The burrowing front legs of the nymphs seem to be modified for a given substrate (coarse for E. simulans; fine for H. limbata) and, the less favourable the substrate, the more work that must be done to gain admittance or to burrow further. The particle size in which the nymphs showed the least oxygen consumption was considered to be an ‘optimal substrate’(χ- 1 for E. simulans and probably silt for H. limbata).


1994 ◽  
Vol 9 (7) ◽  
pp. 1644-1656 ◽  
Author(s):  
Ruyan Guo ◽  
A.S. Bhalla ◽  
L.E. Cross ◽  
Rustum Roy

A review and some case studies on the interatomic distances of candidate substrates in comparison to the high Tc superconductor (HTSC) phase YBa2Cu3O7−δ (YBCO) is presented, in an attempt to enhance the basis for substrate selection for YBCO film epitaxy. This preliminary study was carried out by examining a variety of interatomic distances in the structure rather than merely matching the lattice parameters. Interatomic structure matching planes of selected YBCO orientations in contact with substrates were identified. The surface termination of the substrate was found to be a crucial parameter in determining the oriented or epitaxial growth. Possible composition dependence of the orientation of the films at the nucleation stage was also anticipated depending on the comparison. Several currently most commonly used substrates are discussed in some detail.


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