Response of Human Larynx to Blunt Loading

1973 ◽  
Author(s):  
J. W. Melvin ◽  
R. G. Snyder ◽  
L. W. Travis ◽  
N. R. Olson
Keyword(s):  
1960 ◽  
Vol 74 (12) ◽  
pp. 971-980 ◽  
Author(s):  
Ruth E. M. Bowden ◽  
J. Louise Scheuer

2010 ◽  
Vol 24 (3) ◽  
pp. 252-259 ◽  
Author(s):  
John A. Tucker ◽  
Sean T. Tucker

1998 ◽  
Vol 25 (3) ◽  
pp. 303-308 ◽  
Author(s):  
John S Rubin ◽  
Paul Summers ◽  
Tom Harris

2000 ◽  
Vol 20 (5) ◽  
pp. 411-417 ◽  
Author(s):  
Vladimir S. Akatov ◽  
Yury V. Evtodienko ◽  
Violetta V. Leshchenko ◽  
Vera V. Teplova ◽  
Margarita M. Potselueva ◽  
...  

The combination of hydroxocobalamin (vitamin B12b) and ascorbicacid (vitamin C) can cause the death of tumor cells at the concentrationsof the components at which they are nontoxic when administeredseparately. This cytotoxic action on epidermoid human larynx carcinomacells HEp-2 in vitro is shown to be due to the hydrogen peroxidegenerated by the combination of vitamins B12b and C. The drop inthe glutathione level preceding cell death was found to be the result ofcombined action of the vitamins. It is supposed that the induction of celldeath by combined action of vitamins B12b and C is connected to the damageof the cell redox system.


2012 ◽  
Vol 11 (1) ◽  
pp. 21 ◽  
Author(s):  
Ron Martin ◽  
Boris Thies ◽  
Andreas OH Gerstner
Keyword(s):  

1956 ◽  
Vol 66 (4) ◽  
pp. 410???425 ◽  
Author(s):  
B. Raymond Fink ◽  
Milos Basek ◽  
V. Epanchin
Keyword(s):  

2004 ◽  
Vol 130 (2) ◽  
pp. 217-222 ◽  
Author(s):  
Zhao-Bo Li ◽  
Mohamed Lehar ◽  
Hideki Nakagawa ◽  
Joseph Foon Yoong Hoh ◽  
Paul W. Flint

2018 ◽  
Vol 159 (5) ◽  
pp. 871-878
Author(s):  
James A. Burns ◽  
Stephen D. Adlard ◽  
James B. Kobler ◽  
Monica A. Tynan ◽  
Robert H. Petrillo ◽  
...  

Objectives To compare the physical characteristics of 3 laser-protected endotracheal tubes (LPETs) commonly used in endoscopic laser surgery. To report potential intraoperative problems related to LPET use and suggest practical solutions. Study Design Comparative analysis. Setting Academic laboratory. Subjects and Methods Physical characteristics of the Mallinckrodt Laser-Flex (MTL), Medtronic Laser-Shield II (ML-II), and Rusch LaserTubus (RL) were compared. The effect of bending LPETs on airflow resistance was estimated with a pressure transducer. The force required to pull each tube through the glottis and the pressure exerted during this maneuver were measured in a fresh cadaveric human larynx. Results The design features and physical characteristics of LPETs differ, including varying balloon-tip lengths. Bending LPETs to acute angles caused significant pressure increase within the RL tube (Δ 3.42 cm H2O) and minimal change within the ML-II (Δ 0.12 cm H2O) and MTL (Δ 0.21 cm H2O) tubes. The average force required to pull the RL (48.12 g, P = .003) and MTL (282.4 g, P = .001) tubes through the glottis was 7.6× and 44.5× greater than that for the ML-II (6.39 g). When pulled through the vocal folds, the ML-II cuff exerted no detectable pressure, whereas higher pressures were measured for the RL (2.2 cm H2O) and MTL (6.5 cm H2O) tubes. Conclusion The ML-II tube had the most favorable characteristics, with minimal pressure during extubation and resistance to kinking. The RL tube kinks readily with a resultant increase in resistance to airflow. The MTL tube extends farther into the trachea due to a relatively elongated balloon-tip configuration. Future LPET designs should incorporate features that avoid intraoperative difficulties related to airway protection and ventilation.


ORL ◽  
2021 ◽  
pp. 1-8
Author(s):  
Jhonder Salazar ◽  
Juan-Ramón Gras ◽  
Luis Sanchez-Guillen ◽  
Francisco Sánchez-Del-Campo ◽  
Antonio Arroyo

<b><i>Background:</i></b> To describe the suitability of larynges preserved with Thiel’s embalming method for phonosurgery training. <b><i>Methods:</i></b> A training model for phonosurgery techniques simulating vocal pathology and glottal insufficiency is developed to compare and evaluate the perception of embalmed vocal cords through a voluntary and anonymous survey rated on a scale of 1–5. A total of 10 residents and young otolaryngologists participated in the surgical training in phonosurgery. <b><i>Results:</i></b> Ten larynges preserved in formalin and 10 Thiel’s embalmed larynges were used for the investigation. Phonosurgery procedures were performed following microflap and injection laryngoplasty techniques. The larynges preserved with Thiel’s method demonstrated vocal cords that maintain their pliability and good tissue quality allowing a sensation of realism compared to the living body and providing suitable conditions for realistic laryngeal training. Participants held a positive experience, believed them to be useful and that these models of embalmed larynges were similar to the clinical setting and improved skills and confidence in performing phonosurgery. <b><i>Conclusions:</i></b> The human larynges embalmed with Thiel’s method maintain the pliability of the vocal cords, thus representing a unique model to practice and reproduce training for endolaryngeal procedures without the risks of contamination, anatomical variation, or rigidity of other models.


1987 ◽  
Vol 63 (5) ◽  
pp. 1788-1795 ◽  
Author(s):  
T. X. Jiang ◽  
M. Cauberghs ◽  
K. P. Van de Woestijne

We investigated the impedance of excised preparations of the human larynx before and after resection of the vocal cords and of the trachea whether or not in connection with the main bronchi for steady (75–700 ml.s-1) and oscillatory flows (4–64 Hz). To simulate the influence of respiratory flow on oscillatory resistance (Rosc), oscillatory and steady flow were superimposed. This resulted in a marked increase of Rosc, dependent on the value of steady flow, a change of the frequency dependence of Rosc, and a decrease of the reactance. The latter effects were particularly pronounced in the preparations of the larynx, especially with a narrow glottis opening. The influence of steady flow on oscillatory resistances is probably the expression of interactions of steady and oscillatory flow regimes in the larynx. Similar but less pronounced interactions are also met in the trachea. These effects lead to a systematic overestimation of upper airway resistance when measured during spontaneous breathing by means of a forced oscillation technique.


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