Pressure-Based Abdominal Injury Criteria Using Isolated Liver and Full-Body Post-Mortem Human Subject Impact Tests

Author(s):  
Matthew A. Kremer ◽  
Hannah M. Gustafson ◽  
John H. Bolte ◽  
Jason Stammen ◽  
Bruce Donnelly ◽  
...  
2007 ◽  
Vol 7 (5) ◽  
pp. 111S-112S
Author(s):  
Constantine Demetropoulos ◽  
Srinivasan Sundararajan ◽  
Sukhinder Bilkhu ◽  
Warren Hardy ◽  
King Yang ◽  
...  

2020 ◽  
Author(s):  
Xavier Trosseille ◽  
Philippe Petit ◽  
Jérôme Uriot ◽  
Pascal Potier ◽  
Pascal Baudrit

2021 ◽  
Vol 10 (7) ◽  
pp. 1337
Author(s):  
Astrid Malézieux-Picard ◽  
Cecilia Ferrer Soler ◽  
David De Macedo Ferreira ◽  
Emilie Gaud-Luethi ◽  
Christine Serratrice ◽  
...  

Background: Mechanisms and causes of death in older patients with SARS-CoV-2 infection are still poorly understood. Methods: We conducted in a retrospective monocentric study, a clinical chart review and post-mortem examination of patients aged 75 years and older hospitalized in acute care and positive for SARS-CoV-2. Full body autopsy and correlation with clinical findings and suspected causes of death were done. Results: Autopsies were performed in 12 patients (median age 85 years; median of 4 comorbidities, mainly hypertension and cardiovascular disease). All cases showed exudative or proliferative phases of alveolar damage and/or a pattern of organizing pneumonia. Causes of death were concordant in 6 cases (50%), and undetected diagnoses were found in 6. Five patients died from hypoxemic respiratory failure due to coronavirus disease 2019 (COVID-19), five had another associated diagnosis and two died from alternative causes. Deaths that occurred in the second week were related to SARS-CoV-2 pneumonia whereas those occurring earlier were related mainly to heart failure and those occurring later to complications. Conclusions: Although COVID-19 hypoxemic respiratory failure was the most common cause of death, post-mortem pathological examination revealed that acute decompensation from chronic comorbidities during the first week of COVID-19 and complications in the third week contributed to mortality.


2021 ◽  
Vol 27 ◽  
Author(s):  
L. M. Mikhaleva ◽  
A. L. Cherniaev ◽  
M. V. Samsonova ◽  
O. V. Zayratyants ◽  
L. V. Kakturskiy ◽  
...  

Background: Autopsies on COVID-19 deceased patients have many limitations due to necessary epidemiologic and preventative measures. The ongoing pandemic has caused a significant strain on healthcare systems and is being extensively studied around the world. Clinical data does not always corelate with post-mortem findings. The goal of our study was to find pathognomonic factors associated with COVID-19 mortality in 100 post-mortem full body autopsies.Materials and Methods: Following necessary safety protocol, we performed 100 autopsies on patients who were diagnosed with COVID-19 related death. The macroscopic and microscopic pathologies were evaluated along with clinical and laboratory findings.Results: Extensive coagulopathic changes are seen throughout the bodies of diseased patients. Diffuse alveolar damage is pathognomonic of COVID-19 viral pneumonia, and is the leading cause of lethal outcome in younger patients. Extrapulmonary pathology is predominantly seen in the liver and spleen. Intravascular thrombosis is often widespread and signs of septic shock are often present.Conclusion: The described pathological manifestations of COVID-19 in deceased patients are an insight into the main mechanisms of SARS-CoV-2 associated lethal outcome. The disease bears no obvious bias in severity, but seems to be more severe in some patients, hinting at genetic or epigenetic factors at play.


2015 ◽  
Author(s):  
Philippe Petit ◽  
Xavier Trosseille ◽  
Mathieu Lebarbé ◽  
Pascal Baudrit ◽  
Pascal Potier ◽  
...  

2008 ◽  
Vol 30 (3) ◽  
pp. 185-189 ◽  
Author(s):  
Jerome Delotte ◽  
Michel Behr ◽  
Lionel Thollon ◽  
Pierre-Jean Arnoux ◽  
Patrick Baque ◽  
...  

2006 ◽  
Author(s):  
Adam J. Bartsch ◽  
John H. Bolte ◽  
Alan S. Litsky ◽  
Rodney G. Herriott ◽  
Joseph D. McFadden

2011 ◽  
Author(s):  
Philippe Petit ◽  
Carole Luet ◽  
Pascal Potier ◽  
Guy Vallancien

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