Regulatory mechanism of p38MAPK signaling pathway on renal tissue inflammation in chronic kidney disease and interventional effect of traditional Chinese medicine

2012 ◽  
Author(s):  
ZHAO Qing
Keyword(s):  
Chronic Kidney Disease ◽  
Chinese Medicine ◽  
Kidney Disease ◽  
Traditional Chinese Medicine ◽  
Signaling Pathway ◽  
Regulatory Mechanism ◽  
Renal Tissue ◽  
Tissue Inflammation ◽  
P38mapk Signaling

scholarly journals Mechanisms of Kidney Cell Pyroptosis in Chronic Kidney Disease and the Effects of Traditional Chinese Medicine

2021 ◽  
Vol 2021 ◽  
pp. 1-10
Author(s):  
Baozhu Ding ◽  
Guoping Ma ◽  
Zinuo Wang ◽  
Wenjie Liang ◽  
Weifang Gao
Keyword(s):  
Chronic Kidney Disease ◽  
Chinese Medicine ◽  
Kidney Disease ◽  
Traditional Chinese Medicine ◽  
Signaling Pathway ◽  
Kidney Cell ◽  
Cell Damage ◽  
Public Health Issue ◽  
Ampk Signaling ◽  
Caspase 1

Chronic kidney disease (CKD) is a major public health issue that is highly prevalent worldwide. Pyroptosis is an important pathological mechanism underlying kidney cell damage in CKD and is associated with the classic caspase-1-mediated pathway and nonclassic caspase-4/5/11-mediated pathway. The NLRP3-caspase-1-GSDMD signaling pathway is the key mechanism of kidney cell pyroptosis in CKD, and noncoding RNAs such as lncRNAs and miRNAs are important regulators of kidney cell pyroptosis in CKD. In addition, the NLRP1/AIM2-caspase-1-GSDMD and caspase-3-GSDME signaling pathways have also been shown to mediate kidney cell pyroptosis. Traditional Chinese medicine (TCM) and extracts can interfere with the occurrence and development of kidney cell pyroptosis in CKD by inhibiting the NLRP3 signaling pathway and oxidative stress, activating Nrf-2 signaling, protecting mitochondrial integrity, regulating AMPK signaling, and regulating TXNIP/NLRP3 axis, which have become increasingly prominent. It is critical to explore the effects of TCM on kidney cell pyroptosis in CKD and its mechanisms to identify targets and develop new and effective drugs.

Acupuncture Application in Chronic Kidney Disease and its Potential Mechanisms

2018 ◽  
Vol 46 (06) ◽  
pp. 1169-1185 ◽  
Author(s):  
Wei Xiong ◽  
Fang-Fang He ◽  
Ren-Yu You ◽  
Jing Xiong ◽  
Yu-Mei Wang ◽  
...  
Keyword(s):  
Public Health ◽  
Chronic Kidney Disease ◽  
Renal Function ◽  
Chinese Medicine ◽  
Kidney Disease ◽  
Traditional Chinese Medicine ◽  
Public Health Problem ◽  
Therapeutic Effects ◽  
Major Public Health Problem ◽  
Uremic Pruritus

Chronic kidney disease (CKD) is an increasing major public health problem worldwide. The number of CKD patients on hemodialysis is growing rapidly as well. Acupuncture technique is one of the traditional Chinese medicine methods and has been used in a variety of diseases. Nowadays, the clinical application of acupuncture technique for CKD patients has become the focus for its effectiveness and security. In this paper, we will review the therapeutic effects and mechanisms of different acupuncture techniques for CKD patients. In patients with CKD, acupuncture improves renal function, reduces proteinuria, controls hypertension, corrects anemia, relieves pain, and controls many hemodialysis-related complications such as uremic pruritus, insomnia and fatigue. The mechanisms are related to the regulation of sympathetic nerve and the activation of bioactive chemicals. In conclusion, acupuncture is proved to be beneficial for CKD patients. More research, however, is needed to verify the potential mechanisms.

Sign in / Sign up

Export Citation Format

Share Document