Effect and mechanism of traditional Chinese medicine and their active constituents in postmenopausal osteoporosis

2012 ◽  
Author(s):  
ZHAO Piwen
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Postmenopausal Osteoporosis ◽  
Active Constituents

Discussion on Research Approaches of Traditional Chinese Medicine Syndromes of Postmenopausal Osteoporosis

2016 ◽  
Vol 26 (6) ◽  
pp. 55
Author(s):  
Yuqing SUN ◽  
Bingqi WANG ◽  
Xiang CHEN ◽  
Xuefeng ZHENG ◽  
Yanping LIN
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Postmenopausal Osteoporosis

The Chemical and Biological Properties of Euphorbia kansui

2016 ◽  
Vol 44 (02) ◽  
pp. 253-273 ◽  
Author(s):  
Juan Shen ◽  
Jun Kai ◽  
Yuping Tang ◽  
Li Zhang ◽  
Shulan Su ◽  
...  
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Analytical Method ◽  
Biological Properties ◽  
Antitumor Effects ◽  
Pharmacological Activities ◽  
Active Constituents ◽  
Euphorbia Kansui

Kansui, the root of Euphorbia kansui T.N. Liou ex T.P. Wang, is a well-known traditional Chinese medicine. This paper reviews advances in investigations of the botany, the phytochemistry, the analytical method, the pharmacology and the toxicology of kansui. Nearly 100 compounds have been isolated from kansui and identified, and diterpenes and triterpenes are considered to be the characteristic and bio-active constituents of kansui. They possess multiple pharmacological activities, including diuretic, purgation, and antitumor effects. However, they also have a degree of toxicity, and can cause skin, oral, and gastrointestinal irritation. In this paper, the toxicity-efficacy relationship, attenuation and incompatibility of kansui are further discussed. Several future investigations of kansui are also proposed, all of which would improve the identification of kansui and other toxic herbs, as well as further their utilization.

scholarly journals Network Pharmacology-Based Analysis of Xiao-Xu-Ming Decoction on the Treatment of Alzheimer’s Disease

2020 ◽  
Vol 11 ◽  
Author(s):  
Yanjia Shen ◽  
Baoyue Zhang ◽  
Xiaocong Pang ◽  
Ran Yang ◽  
Miao Chen ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Network Pharmacology ◽  
Potential Treatment ◽  
Active Constituents ◽  
Lead Compounds ◽  
Ache Inhibitors

Alzheimer's disease (AD) has become a worldwide disease that is harmful to human health and brings a heavy economic burden to healthcare system. Xiao-Xu-Ming Decoction (XXMD) has been widely used to treat stroke and other neurological diseases for more than 1000 years in China. However, the synergistic mechanism of the constituents in XXMD for the potential treatment of AD is still unclear. Therefore, the present study aimed to predict the potential targets and uncover the material basis of XXMD for the potential treatment of AD. A network pharmacology-based method, which combined data collection, drug-likeness filtering and absorption, distribution, metabolism, excretion and toxicity (ADME/T) properties filtering, target prediction and network analysis, was used to decipher the effect and potential targets of XXMD for the treatment of AD. Then, the acetylcholinesterase (AChE) inhibitory assay was used to screen the potential active constituents in XXMD for the treatment of AD, and the molecular docking was furtherly used to identify the binding ability of active constituents with AD-related target of AChE. Finally, three in vitro cell models were applied to evaluate the neuroprotective effects of potential lead compounds in XXMD. Through the China Natural Products Database, Traditional Chinese Medicine Systems Pharmacology (TCMSP) Database, Traditional Chinese Medicine (TCM)-Database @Taiwan and literature, a total of 1481 compounds in XXMD were finally collected. After ADME/T properties filtering, 908 compounds were used for the further study. Based on the prediction data, the constituents in XXMD formula could interact with 41 AD-related targets. Among them, cyclooxygenase-2 (COX-2), estrogen receptor α (ERα) and AChE were the major targets. The constituents in XXMD were found to have the potential to treat AD through multiple AD-related targets. 62 constituents in it were found to interact with more than or equal to 10 AD-related targets. The prediction results were further validated by in vitro biology experiment, resulting in several potential anti-AD multitarget-directed ligands (MTDLs), including two AChE inhibitors with the IC50 values ranging from 4.83 to 10.22 μM. Moreover, fanchinoline was furtherly found to prevent SH-SY5Y cells from the cytotoxicities induced by sodium nitroprusside, sodium dithionate and potassium chloride. In conclusion, XXMD was found to have the potential to treat AD by targeting multiple AD-related targets and canonical pathways. Fangchinoline and dauricine might be the potential lead compounds in XXMD for the treatment of AD.

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