scholarly journals A new case of dic(1;15) in essential thrombocythaemia with JAK2 V617F mutation

2012 ◽  
Author(s):  
Pereira Velloso ED Rodrigues ◽  
Ratis C Alonso ◽  
RK Kishimoto ◽  
Oliveira D Aquilino ◽  
Misael NC de Sousa ◽  
...  
Keyword(s):  
Jak2 V617f ◽  
Jak2 V617f Mutation ◽  
Essential Thrombocythaemia ◽  
V617f Mutation

JAK2 V617F MUTATION AND PRV-1 OVEREXPRESSION: RELEVANCE IN THE DIAGNOSIS OF POLYCYTHAEMIA VERA AND ESSENTIAL THROMBOCYTHAEMIA

2009 ◽  
Vol 64 (5) ◽  
pp. 429-433
Author(s):  
S. Melis ◽  
S. Vellinga ◽  
P. Zachée ◽  
AC. Sierens ◽  
PJJC. De Schouwer
Keyword(s):  
Jak2 V617f ◽  
Jak2 V617f Mutation ◽  
Polycythaemia Vera ◽  
Essential Thrombocythaemia ◽  
V617f Mutation

Definition of subtypes of essential thrombocythaemia and relation to polycythaemia vera based on JAK2 V617F mutation status: a prospective study

The Lancet ◽  
2005 ◽  
Vol 366 (9501) ◽  
pp. 1945-1953 ◽  
Author(s):  
Peter J Campbell ◽  
Linda M Scott ◽  
Georgina Buck ◽  
Keith Wheatley ◽  
Clare L East ◽  
...  
Keyword(s):  
Prospective Study ◽  
Jak2 V617f ◽  
Jak2 V617f Mutation ◽  
Polycythaemia Vera ◽  
Essential Thrombocythaemia ◽  
Mutation Status ◽  
V617f Mutation ◽  
Definition Of ◽  
A Prospective Study

JAK2 V617F mutation is associated with increased risk of thrombosis in Chinese patients with essential thrombocythaemia

2008 ◽  
Vol 141 (6) ◽  
pp. 902-904 ◽  
Author(s):  
Raymond S. M. Wong ◽  
Chi-Keung Cheng ◽  
Natalie P. H. Chan ◽  
Suk-Hang Cheng ◽  
Wai-Shan Wong ◽  
...  
Keyword(s):  
Jak2 V617f ◽  
Jak2 V617f Mutation ◽  
Chinese Patients ◽  
Essential Thrombocythaemia ◽  
Increased Risk ◽  
V617f Mutation

Genetic heterogeneity of granulocytes for the JAK2 V617F mutation in essential thrombocythaemia: implications for mutation detection in peripheral blood

Pathology ◽  
2006 ◽  
Vol 38 (4) ◽  
pp. 336-342 ◽  
Author(s):  
William S. Stevenson ◽  
Rosemary Hoyt ◽  
Anthony Bell ◽  
Michel Guipponi ◽  
Surender Juneja ◽  
...  
Keyword(s):  
Genetic Heterogeneity ◽  
Peripheral Blood ◽  
Mutation Detection ◽  
Jak2 V617f ◽  
Jak2 V617f Mutation ◽  
Essential Thrombocythaemia ◽  
V617f Mutation

scholarly journals The presence of the JAK2 V617F mutation is associated with a higher haemoglobin and increased risk of thrombosis in essential thrombocythaemia

2006 ◽  
Vol 132 (2) ◽  
pp. 244-245 ◽  
Author(s):  
Betty Cheung ◽  
Deepti Radia ◽  
Panagiotis Pantelidis ◽  
Ghasem Yadegarfar ◽  
Claire Harrison
Keyword(s):  
Jak2 V617f ◽  
Jak2 V617f Mutation ◽  
Essential Thrombocythaemia ◽  
Increased Risk ◽  
V617f Mutation

Is JAK2 V617F mutation more than a diagnostic index?

2009 ◽  
Vol 33 (1) ◽  
pp. 67-73 ◽  
Author(s):  
Issa J. Dahabreh ◽  
Katerina Zoi ◽  
Stavroula Giannouli ◽  
Christine Zoi ◽  
Dimitrios Loukopoulos ◽  
...  
Keyword(s):  
Jak2 V617f ◽  
Jak2 V617f Mutation ◽  
V617f Mutation ◽  
Diagnostic Index

scholarly journals CRISPR/Cas12a-Based Ultrasensitive and Rapid Detection of JAK2 V617F Somatic Mutation in Myeloproliferative Neoplasms

Biosensors ◽  
2021 ◽  
Vol 11 (8) ◽  
pp. 247
Author(s):  
Miaomiao Chen ◽  
Chunhua Zhang ◽  
Zhiqing Hu ◽  
Zhuo Li ◽  
Menglin Li ◽  
...  
Keyword(s):  
Detection System ◽  
Myeloproliferative Neoplasms ◽  
Cost Effective ◽  
Jak2 V617f ◽  
Jak2 V617f Mutation ◽  
Minimum Detectable Concentration ◽  
Lateral Flow Strip ◽  
Whole Process ◽  
Detectable Concentration ◽  
V617f Mutation

The JAK2 V617F mutation is a major diagnostic, therapeutic, and monitoring molecular target of Philadelphia-negative myeloproliferative neoplasms (MPNs). To date, numerous methods of detecting the JAK2 V617F mutation have been reported, but there is no gold-standard diagnostic method for clinical applications. Here, we developed and validated an efficient Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/CRISPR associated protein 12a (Cas12a)-based assay to detect the JAK2 V617F mutation. Our results showed that the sensitivity of the JAK2 V617F/Cas12a fluorescence detection system was as high as 0.01%, and the JAK2 V617F/Cas12a lateral flow strip assay could unambiguously detect as low as 0.5% of the JAK2 V617F mutation, which was much higher than the sensitivity required for clinical application. The minimum detectable concentration of genomic DNA achieved was 0.01 ng/μL (~5 aM, ~3 copies/μL). In addition, the whole process only took about 1.5 h, and the cost of an individual test was much lower than that of the current assays. Thus, our methods can be applied to detect the JAK2 V617F mutation, and they are highly sensitive, rapid, cost-effective, and convenient.

scholarly journals The study of Jak2 V617F mutation in polycythemia vera with zebrafish model

Cell Research ◽  
2008 ◽  
Vol 18 (S1) ◽  
pp. S141-S141
Author(s):  
Alvin CH Ma ◽  
Alice MS Cheung ◽  
Alister C Ward ◽  
Wing-Yan Au ◽  
Yok-Lam Kwong ◽  
...  
Keyword(s):  
Polycythemia Vera ◽  
Jak2 V617f ◽  
Jak2 V617f Mutation ◽  
Zebrafish Model ◽  
V617f Mutation
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