scholarly journals NSD1 (nuclear receptor-binding, su(var), enhancer-of-zeste and trithorax domain-containing protein 1

2011 ◽  
Author(s):  
L Kearney
Keyword(s):  
Nuclear Receptor ◽  
Receptor Binding ◽  
Enhancer Of Zeste

scholarly journals DNA Sequence Constraints Define Functionally Active Steroid Nuclear Receptor Binding Sites in Chromatin

Endocrinology ◽  
2017 ◽  
Vol 158 (10) ◽  
pp. 3212-3234 ◽  
Author(s):  
Laurel A Coons ◽  
Sylvia C Hewitt ◽  
Adam B Burkholder ◽  
Donald P McDonnell ◽  
Kenneth S Korach
Keyword(s):  
Dna Sequence ◽  
Nuclear Receptor ◽  
Receptor Binding ◽  
Binding Sites ◽  
Sequence Constraints

scholarly journals Nuclear receptor binding protein 1 regulates intestinal progenitor cell homeostasis and tumour formation

2012 ◽  
Vol 31 (11) ◽  
pp. 2486-2497 ◽  
Author(s):  
Catherine H Wilson ◽  
Catriona Crombie ◽  
Louise van der Weyden ◽  
George Poulogiannis ◽  
Alistair G Rust ◽  
...  
Keyword(s):  
Nuclear Receptor ◽  
Receptor Binding ◽  
Progenitor Cell ◽  
Binding Protein ◽  
Cell Homeostasis ◽  
Tumour Formation ◽  
Receptor Binding Protein

A pleiotropic element in the medium-chain acyl coenzyme A dehydrogenase gene promoter mediates transcriptional regulation by multiple nuclear receptor transcription factors and defines novel receptor-DNA binding motifs

1994 ◽  
Vol 14 (7) ◽  
pp. 4360-4372
Author(s):  
M E Carter ◽  
T Gulick ◽  
D D Moore ◽  
D P Kelly
Keyword(s):  
Transcriptional Regulation ◽  
Nuclear Receptor ◽  
Receptor Binding ◽  
Gene Promoter ◽  
Response Element ◽  
Binding Motifs ◽  
Receptor Response ◽  
Dehydrogenase Gene ◽  
Chain Acyl ◽  
Acyl Coenzyme A

We previously identified a complex regulatory element in the medium-chain acyl coenzyme A dehydrogenase gene promoter that confers transcriptional regulation by the retinoid receptors RAR and RXR and the orphan nuclear receptor HNF-4. In this study we demonstrate a trans-repressing regulatory function for the orphan receptor COUP-TF at this same nuclear receptor response element (NRRE-1). The transcriptional regulatory properties and receptor binding sequences of each nuclear receptor response element within NRRE-1 are also characterized. NRRE-1 consists of four potential nuclear hormone receptor hexamer binding sites, arranged as [<--1-(n)s-2-->-3-->(n)4<--4], three of which are used in alternative pairwise binding by COUP-TF and HNF-4 homodimers and by RAR-RXR heterodimers, as demonstrated by mobility shift assays and methylation interference analysis. Binding and transactivation studies with mutant NRRE-1 elements confirmed the existence of distinct retinoid, COUP-TF, and HNF-4 response elements that define novel receptor binding motifs: COUP-TF homodimers bound sites 1 and 3 (two hexamer repeat sequences arranged as an everted imperfect repeat separated by 14 bp or ER14), RAR-RXR heterodimers bound sites 1 and 2 (ER8), and HNF-4 homodimers bound sites 2 and 3 (imperfect DR0). Mixing cotransfection experiments demonstrated that the nuclear receptor dimers compete at NRRE-1 to modulate constitutive and ligand-mediated transcriptional activity. These data suggest a mechanism for the transcriptional modulation of genes encoding enzymes involved in cellular metabolism.

Nuclear receptor binding factor 2 (NRBF2) is required for learning and memory

2020 ◽  
Vol 100 (9) ◽  
pp. 1238-1251 ◽  
Author(s):  
Xiaosen Ouyang ◽  
Israr Ahmad ◽  
Michelle S. Johnson ◽  
Matthew Redmann ◽  
Jason Craver ◽  
...  
Keyword(s):  
Learning And Memory ◽  
Nuclear Receptor ◽  
Receptor Binding ◽  
Binding Factor
Sign in / Sign up

Export Citation Format

Share Document