scholarly journals Effects of Pinacidil on ST-T Wave Alternans During Acute Myocardial Ischemia in the In-situ Pig Heart

2017 ◽  
Vol 76 (6) ◽  
pp. 273-279
Author(s):  
Ichiro Watanabe ◽  
Leonard S. Gettes
Keyword(s):  
Myocardial Ischemia ◽  
Acute Myocardial Ischemia ◽  
T Wave ◽  
T Wave Alternans

scholarly journals Investigating two kinds of cellular alternans and corresponding TWA induced by impaired calcium cycling in myocardial ischemia

2021 ◽  
Vol 18 (6) ◽  
pp. 7648-7665
Author(s):  
Jiaqi Liu ◽  
◽  
Zhenyin Fu ◽  
Yinglan Gong ◽  
Ling Xia
Keyword(s):  
Myocardial Ischemia ◽  
Conduction Velocity ◽  
Ionic Channel ◽  
Calcium Cycling ◽  
One Dimensional ◽  
T Wave ◽  
Cell Simulation ◽  
T Wave Alternans ◽  
Dimensional Simulation ◽  
The Relationship

<abstract> <sec><title>Background</title><p>The utility of T wave alternans (TWA) in identifying arrhythmia risk has been demonstrated. During myocardial ischemia (MI), TWA could be induced by cellular alternans. However, the relationship between cellular alternans patterns and TWA patterns in MI has not been investigated thoroughly.</p> </sec> <sec><title>Methods</title><p>We set MI conditions to simulate alternans. Either prolonging Ca<sup>2+</sup> release or increasing spark-induced sparks (secondary sparks) can give rise to different patterns of APD alternans and TWA. In addition, different ischemic zones and reduced conduction velocity are also considered in one dimensional simulation.</p> </sec> <sec><title>Results</title><p>Delay of Ca<sup>2+</sup> release can produce discordant Ca<sup>2+</sup>-driven alternans in single cell simulation. Increasing secondary sparks leads to concordant alternans. Correspondingly, morphology and magnitude of TWA vary in two different cellular alternans. Epi ischemia results in alternans concentrating in the first half of T wave. Endo and transmural ischemia lead to fluctuations in the second half of T wave. In addition, slowing conduction velocity has no effect on TWA magnitude.</p> </sec> <sec><title>Conclusion</title><p>Specific ionic channel dysfunction and ischemic zones affect TWA patterns.</p> </sec> </abstract>

scholarly journals The value of microvolt T-wave alternans in the diagnosis of reversible myocardial ischemia in patients without structural cardiac disease.

2015 ◽  
Vol 10 (9-10) ◽  
pp. 239-239
Author(s):  
Mislav Puljevic ◽  
Josko Bulum ◽  
Aleksander Ernst ◽  
Davor Milicic ◽  
Davor Puljevic
Keyword(s):  
Myocardial Ischemia ◽  
Cardiac Disease ◽  
T Wave ◽  
T Wave Alternans

scholarly journals TWARMI pilot trial: The value and optimal criteria of microvolt T-wave alternans in the diagnosis of reversible myocardial ischemia in patients without structural cardiac disease

2018 ◽  
Vol 24 (2) ◽  
pp. e12610
Author(s):  
Mislav Puljevic ◽  
Ludmila Danilowicz-Szymanowicz ◽  
Giulio Molon ◽  
Davor Puljevic ◽  
Grzegorz Raczak ◽  
...  
Keyword(s):  
Myocardial Ischemia ◽  
Cardiac Disease ◽  
Pilot Trial ◽  
T Wave ◽  
T Wave Alternans

scholarly journals De Winter T-wave Pattern in Proximal Left Anterior Descending Artery Occlusion

2020 ◽  
Vol 4 (3) ◽  
pp. 476-477
Author(s):  
David Gregory ◽  
Bryan Wexler ◽  
Brent Becker
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Myocardial Ischemia ◽  
Cardiac Catheterization ◽  
Wave Pattern ◽  
Artery Occlusion ◽  
Acute Myocardial Ischemia ◽  
Case Presentation ◽  
T Wave ◽  
Left Anterior Descending Artery

Case Presentation: We describe a case of an acute myocardial infarction with an atypical electrocardiogram showing a de Winter T-wave pattern suggesting the 100% proximal left anterior descending artery occlusion seen on emergent cardiac catheterization. Discussion: Timely recognition of acute myocardial ischemia is paramount for emergency providers. As highlighted in this case, It is important to be mindful of atypical electrocardiogram findings, such as de Winter T-waves, which suggest acute myocardial ischemia.

Sign in / Sign up

Export Citation Format

Share Document